公开(公告)号：US20060261278A1

公开(公告)日：2006-11-23

申请号：US10554895

申请日：2004-04-28

申请人： Roberto Accorsi

发明人： Roberto Accorsi

IPC分类号： G01T1/164

CPC分类号： G01T1/2985 ,  G01T1/295

摘要： The method of imaging a spatial distribution of photon emitters, the method includes producing an image with a resolution of at most about 180 microns using an imaging device including a detector and a coded aperture, wherein a photon emitted from the photon emitter has an energy of at most about 35 keV (5.6×10−15 J). Further provided is an imaging device for imaging a distribution of photons having energies of at most about 35 keV (5.6×10−15 J), which includes a coded aperture comprising a mask pattern having a plurality of holes, wherein the coded aperture is adapted to provide a resolution of at most about 180 micron, a detector on which a raw image is projected through the coded aperture; and a decoder that receives the raw image from the detector and produces an image having a resolution of at most about 180 micron.

摘要翻译： 用于对光子发射器的空间分布进行成像的方法，所述方法包括使用包括检测器和编码孔径的成像装置产生具有至多约180微米的分辨率的图像，其中从所述光子发射器发射的光子具有 至多约35keV（5.6x10 -15 J）。 还提供了一种用于对具有最多约35keV（5.6×10 -15 J）的能量的光子分布成像的成像装置，其包括编码孔径，其包括具有多个孔的掩模图案， 其中所述编码孔径适于提供至多约180微米的分辨率，其上原始图像通过所述编码孔径投射到其上的检测器; 以及解码器，其从检测器接收原始图像，并产生具有至多约180微米的分辨率的图像。

公开(公告)号：US20090304150A1

公开(公告)日：2009-12-10

申请号：US12293422

申请日：2007-03-19

申请人： Scott Metzler ,  Roberto Accorsi ,  Robert M. Lewitt

发明人： Scott Metzler ,  Roberto Accorsi ,  Robert M. Lewitt

IPC分类号： G01N23/04 ,  G21K1/02

CPC分类号： G01T1/1648 ,  G02B27/30

摘要： This invention is directed to a collimator and collimation techniques. Specifically, the invention is directed to a collimator and method for collimation wherein the collimator combines the resolution and sensitivity properties of pinhole Single Photon Emission Computed Tomography (SPECT) imaging with the 2D complete-sampling properties of fan-beam collimators.

摘要翻译： 本发明涉及一种准直器和准直技术。 具体地，本发明涉及准直器和准直方法，其中准直器将针孔单光子发射计算机断层扫描（SPECT）成像的分辨率和灵敏度特性与扇形光束准直器的2D完全采样特性相结合。

公开(公告)号：US07831024B2

公开(公告)日：2010-11-09

申请号：US12293422

申请日：2007-03-19

申请人： Scott Metzler ,  Roberto Accorsi ,  Robert M. Lewitt

发明人： Scott Metzler ,  Roberto Accorsi ,  Robert M. Lewitt

IPC分类号： G21K1/04

CPC分类号： G01T1/1648 ,  G02B27/30

摘要： This invention is directed to a collimator and collimation techniques. Specifically, the invention is directed to a collimator and method for collimation wherein the collimator combines the resolution and sensitivity properties of pinhole Single Photon Emission Computed Tomography (SPECT) imaging with the 2D complete-sampling properties of fan-beam collimators.

摘要翻译： 本发明涉及一种准直器和准直技术。 具体地，本发明涉及准直器和准直方法，其中准直器将针孔单光子发射计算机断层扫描（SPECT）成像的分辨率和灵敏度特性与扇形光束准直器的2D完全采样特性相结合。

公开(公告)号：US20080240535A1

公开(公告)日：2008-10-02

申请号：US12132500

申请日：2008-06-03

申请人： John V. Frangioni ,  Roberto Accorsi ,  Richard C. Lanza ,  John Idoine

发明人： John V. Frangioni ,  Roberto Accorsi ,  Richard C. Lanza ,  John Idoine

IPC分类号： G06K9/00

CPC分类号： A61B5/0059 ,  A61B5/415 ,  A61B5/418 ,  A61B6/00 ,  A61B6/037 ,  A61B6/4417 ,  A61B6/5247 ,  G01T1/1603 ,  G01T1/295 ,  G06F19/00

摘要： The invention relates to imaging systems that include a coded aperture detection system and an optical detection system. The coded aperture detection system is configured to detect radiation emitted by a radionuclide present within an object and to provide a first detector signal from the detected radiation. The optical detection system is configured to detect optical radiation from the object and to provide a second detector signal from the detected optical radiation. The system also includes a processor configured to prepare first image data from the first detector signal, second image data from the second detector signal, and registered data indicative of a spatial relationship in at least one dimension between the first and second image data. The invention also includes methods of using the new systems, e.g., for sentinel lymph node mapping and tissue resection.

摘要翻译： 本发明涉及包括编码孔径检测系统和光学检测系统的成像系统。 编码孔径检测系统被配置为检测存在于物体内的放射性核素发射的辐射并且从所检测的辐射提供第一检测器信号。 光学检测系统被配置为检测来自物体的光辐射并且从检测到的光辐射提供第二检测器信号。 该系统还包括配置成从第一检测器信号准备第一图像数据，来自第二检测器信号的第二图像数据和指示第一和第二图像数据之间的至少一维中的空间关系的登记数据的处理器。 本发明还包括使用新系统的方法，例如用于前哨淋巴结作图和组织切除术。

公开(公告)号：US20060108509A1

公开(公告)日：2006-05-25

申请号：US11222864

申请日：2005-09-09

申请人： John Frangioni ,  Roberto Accorsi ,  Richard Lanza ,  John Idoine

发明人： John Frangioni ,  Roberto Accorsi ,  Richard Lanza ,  John Idoine

IPC分类号： H01L27/00

CPC分类号： A61B5/0059 ,  A61B5/415 ,  A61B5/418 ,  A61B6/00 ,  A61B6/037 ,  A61B6/4417 ,  A61B6/5247 ,  G01T1/1603 ,  G01T1/295 ,  G06F19/00

摘要： The invention relates to imaging systems that include a coded aperture detection system and an optical detection system. The coded aperture detection system is configured to detect radiation emitted by a radionuclide present within an object and to provide a first detector signal from the detected radiation. The optical detection system is configured to detect optical radiation from the object and to provide a second detector signal from the detected optical radiation. The system also includes a processor configured to prepare first image data from the first detector signal, second image data from the second detector signal, and registered data indicative of a spatial relationship in at least one dimension between the first and second image data. The invention also includes methods of using the new systems, e.g., for sentinel lymph node mapping and tissue resection.

摘要翻译： 本发明涉及包括编码孔径检测系统和光学检测系统的成像系统。 编码孔径检测系统被配置为检测存在于物体内的放射性核素发射的辐射并且从所检测的辐射提供第一检测器信号。 光学检测系统被配置为检测来自物体的光辐射并且从检测到的光辐射提供第二检测器信号。 该系统还包括配置成从第一检测器信号准备第一图像数据，来自第二检测器信号的第二图像数据和指示第一和第二图像数据之间的至少一维中的空间关系的登记数据的处理器。 本发明还包括使用新系统的方法，例如用于前哨淋巴结作图和组织切除术。

公开(公告)号：US07759625B2

公开(公告)日：2010-07-20

申请号：US12132500

申请日：2008-06-03

申请人： John V. Frangioni ,  Roberto Accorsi ,  Richard C. Lanza ,  John Idoine

发明人： John V. Frangioni ,  Roberto Accorsi ,  Richard C. Lanza ,  John Idoine

IPC分类号： G01L27/00

CPC分类号： A61B5/0059 ,  A61B5/415 ,  A61B5/418 ,  A61B6/00 ,  A61B6/037 ,  A61B6/4417 ,  A61B6/5247 ,  G01T1/1603 ,  G01T1/295 ,  G06F19/00

摘要： The invention relates to imaging systems that include a coded aperture detection system and an optical detection system. The coded aperture detection system is configured to detect radiation emitted by a radionuclide present within an object and to provide a first detector signal from the detected radiation. The optical detection system is configured to detect optical radiation from the object and to provide a second detector signal from the detected optical radiation. The system also includes a processor configured to prepare first image data from the first detector signal, second image data from the second detector signal, and registered data indicative of a spatial relationship in at least one dimension between the first and second image data. The invention also includes methods of using the new systems, e.g., for sentinel lymph node mapping and tissue resection.

摘要翻译： 本发明涉及包括编码孔径检测系统和光学检测系统的成像系统。 编码孔径检测系统被配置为检测存在于物体内的放射性核素发射的辐射并且从所检测的辐射提供第一检测器信号。 光学检测系统被配置为检测来自物体的光辐射并且从检测到的光辐射提供第二检测器信号。 该系统还包括配置成从第一检测器信号准备第一图像数据，来自第二检测器信号的第二图像数据和指示第一和第二图像数据之间的至少一维中的空间关系的登记数据的处理器。 本发明还包括使用新系统的方法，例如用于前哨淋巴结作图和组织切除术。

公开(公告)号：US07394053B2

公开(公告)日：2008-07-01

申请号：US11222864

申请日：2005-09-09

申请人： John V. Frangioni ,  Roberto Accorsi ,  Richard C. Lanza ,  John Idoine

发明人： John V. Frangioni ,  Roberto Accorsi ,  Richard C. Lanza ,  John Idoine

IPC分类号： H01L27/00

CPC分类号： A61B5/0059 ,  A61B5/415 ,  A61B5/418 ,  A61B6/00 ,  A61B6/037 ,  A61B6/4417 ,  A61B6/5247 ,  G01T1/1603 ,  G01T1/295 ,  G06F19/00

摘要： The invention relates to imaging systems that include a coded aperture detection system and an optical detection system. The coded aperture detection system is configured to detect radiation emitted by a radionuclide present within an object and to provide a first detector signal from the detected radiation. The optical detection system is configured to detect optical radiation from the object and to provide a second detector signal from the detected optical radiation. The system also includes a processor configured to prepare first image data from the first detector signal, second image data from the second detector signal, and registered data indicative of a spatial relationship in at least one dimension between the first and second image data. The invention also includes methods of using the new systems, e.g., for sentinel lymph node mapping and tissue resection.

摘要翻译： 本发明涉及包括编码孔径检测系统和光学检测系统的成像系统。 编码孔径检测系统被配置为检测存在于物体内的放射性核素发射的辐射并且从所检测的辐射提供第一检测器信号。 光学检测系统被配置为检测来自物体的光辐射并且从检测到的光辐射提供第二检测器信号。 该系统还包括配置成从第一检测器信号准备第一图像数据，来自第二检测器信号的第二图像数据和指示第一和第二图像数据之间的至少一维中的空间关系的登记数据的处理器。 本发明还包括使用新系统的方法，例如用于前哨淋巴结作图和组织切除术。

公开(公告)号：US20070040124A1

公开(公告)日：2007-02-22

申请号：US10557062

申请日：2004-04-28

申请人： Roberto Accorsi

发明人： Roberto Accorsi

IPC分类号： G01T1/164

CPC分类号： G01T1/295

摘要： The invention is based on the discovery that using at least two detectors in near-field imaging, wherein each detector is located on opposing sides of an object at about a 180 degree angle relative to the other detector, and equipping the detectors with two different copies of the same coded aperture, rotated at about a 90 degree angle relative to each other, minimizes near-field artifacts in images of non-static objects. The near-field coded aperture device and a method for minimizing artifacts by utilizing the device are provided. A method for detecting contraband in cargo is also provided.

摘要翻译： 本发明基于以下发现：在近场成像中使用至少两个检测器，其中每个检测器相对于另一检测器以大约180度的角度位于物体的相对侧上，并且将检测器装配到两个不同的拷贝 相同的编码孔径相对于彼此以大约90度的角度旋转，使非静态物体的图像中的近场伪影最小化。 提供了近场编码孔径装置和通过利用该装置来最小化伪影的方法。 还提供了检测货物违禁品的方法。

公开(公告)号：US06737652B2

公开(公告)日：2004-05-18

申请号：US09966357

申请日：2001-09-28

申请人： Richard C. Lanza ,  Roberto Accorsi ,  Francesca Gasparini

发明人： Richard C. Lanza ,  Roberto Accorsi ,  Francesca Gasparini

IPC分类号： G01T1164

CPC分类号： G01T1/295

摘要： Improved systems and methods for coded aperture imaging of radiation-emitting sources. According to one aspect, the present invention is directed to reducing and/or eliminating the artifacts that are inherent in previous near field coded aperture imaging systems such that the improved sensitivity and resolution of these systems can be practically utilized. A system and method of the present invention utilizes two projections of radiation from an object, the first through a first coded aperture mask pattern, and the second through a second coded aperture mask pattern, where a decoding array associated with the second mask pattern is the negative of a decoding array associated with the first mask pattern. Data from both projections is combined to produce a reconstructed object image that is substantially free of near-field artifacts. The present invention additionally relates to further improvements in the sensitivity and spatial resolution of coded aperture imaging applications. More particularly, the present invention relates to improvements in the design and fabrication of coded aperture masks for use in coded aperture imaging devices. Improvements can be made to the resolution, for instance, by selecting smaller pixel sizes for the opaque and transparent elements of the coded aperture mask. Also, it is possible to improve the signal-to-noise ratio for near-field applications by selecting an appropriate thickness for the mask. The signal-to-noise ratio may be further improved by selecting the appropriate mask pattern based on the particular characteristics of the near-field imaging problem at hand.

摘要翻译： 用于辐射源的编码孔径成像的改进的系统和方法。 根据一个方面，本发明旨在减少和/或消除先前的近场编码孔径成像系统中固有的假象，使得可以实际地利用这些系统的改进的灵敏度和分辨率。一种系统和方法 本发明利用来自物体的辐射的两个投影，第一至第一编码孔径掩模图案，以及第二通过第二编码孔径掩模图案，其中与第二掩模图案相关联的解码阵列是相关联的解码阵列的负值 与第一个掩模图案。 来自两个投影的数据被组合以产生基本上没有近场伪像的重建对象图像。本发明还涉及编码孔径成像应用的灵敏度和空间分辨率的进一步改进。 更具体地，本发明涉及用于编码孔径成像装置中的编码孔径掩模的设计和制造的改进。 可以对分辨率进行改进，例如通过为编码孔径掩模的不透明和透明元素选择较小的像素尺寸。 此外，通过为掩模选择适当的厚度，可以提高近场应用的信噪比。 可以通过基于近场成像问题的特定特征选择适当的掩模图案来进一步改善信噪比。