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公开(公告)号：US08198403B2
公开(公告)日：2012-06-12
申请号：US11441480
申请日：2006-05-26
申请人： Gregg R. Dieckmann , Alfonzo Ortiz-Acevedo , Ray Baughman , Alan B. Dalton , Rockford K. Draper , Inga H. Musselman
发明人： Gregg R. Dieckmann , Alfonzo Ortiz-Acevedo , Ray Baughman , Alan B. Dalton , Rockford K. Draper , Inga H. Musselman
CPC分类号： C07K7/08 , B82Y30/00 , B82Y40/00 , C01B32/174 , C01B2202/02 , C01B2202/36 , C07K7/06 , Y10S977/746 , Y10S977/845 , Y10S977/847
摘要： The present invention includes compositions and methods for the isolation, separation and chelation of Carbon Nanotubes (CNTs) using a cyclizable peptide.
摘要翻译： 本发明包括使用可环化肽分离，分离和螯合碳纳米管（CNT）的组合物和方法。
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2.发明申请公开(公告)号：US20110203927A1
公开(公告)日：2011-08-25
申请号：US13121395
申请日：2009-10-02
IPC分类号： G01N27/447 , G01N33/559 , G01N33/68 , B82Y40/00
CPC分类号： G01N27/44717 , G01N33/54346 , G01N2015/0038 , G01N2015/0693
摘要： The present invention provides methods, apparatuses and kits for determining the presence and the concentration of nanoparticles in a given area, solution or region via cellular uptake and/or adsorption monitored through laboratory equipment. For example, the present invention provides a method of quantifying one or more nanoparticles by incubating a nanoparticle solution comprising one or more nanoparticles with one or more cells; isolating the one or more cells; lysing the one or more cells to release a cell lysate; separating the cell lysate electrophoretically on a gel; digitizing the gel to form a gel image; quantifying the nanoparticle intensity in the gel image; and correlating the nanoparticle intensity to a cell-associated nanoparticle concentration.
摘要翻译： 本发明提供用于通过实验室设备监测的细胞摄取和/或吸附来确定给定区域，溶液或区域中纳米颗粒的存在和浓度的方法，装置和试剂盒。 例如，本发明提供了通过将包含一种或多种纳米颗粒的纳米颗粒溶液与一种或多种细胞孵育来定量一种或多种纳米颗粒的方法; 隔离一个或多个细胞; 裂解一个或多个细胞以释放细胞裂解物; 在凝胶上电泳分离细胞裂解物; 将凝胶数字化以形成凝胶图像; 量化凝胶图像中的纳米颗粒强度; 并将纳米颗粒强度与细胞相关纳米颗粒浓度相关联。
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3.发明申请METHODS AND MATERIALS FOR EXTRA AND INTRACELLULAR DELIVERY OF CARBON NANOTUBES 审中-公开碳纳米管超细和细胞内输送的方法和材料公开(公告)号：US20080227168A1
公开(公告)日：2008-09-18
申请号：US12032665
申请日：2008-02-16
申请人： Tanja Kmecko , Gareth Hughes , Rockford K Draper , Robert M. Burgess , Austin David-Edmiston Swafford
发明人： Tanja Kmecko , Gareth Hughes , Rockford K Draper , Robert M. Burgess , Austin David-Edmiston Swafford
CPC分类号： C12N13/00 , A61K9/0092 , A61K41/0052 , A61K47/6925 , B82Y5/00
摘要： The present invention includes compositions and methods to deliver carbon nanostructures that include agents for delivery to cells, wherein the carbon nanostructure and the agent are made soluble by coating the carbon nanostructure with one or more polymers, e.g., low band gap conductive polymers.
摘要翻译： 本发明包括用于递送碳纳米结构的组合物和方法，其包括用于递送至细胞的试剂，其中通过用一种或多种聚合物（例如低带隙导电聚合物）涂覆碳纳米结构使得碳纳米结构和试剂变得可溶。
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4.发明授权Method for measuring carbon nanotubes taken-up by a plurality of living cells 有权用于测量由多个活细胞摄取的碳纳米管的方法公开(公告)号：US08632671B2
公开(公告)日：2014-01-21
申请号：US13121395
申请日：2009-10-02
IPC分类号： G01N27/447
CPC分类号： G01N27/44717 , G01N33/54346 , G01N2015/0038 , G01N2015/0693
摘要： The present invention provides methods, apparatuses and kits for determining the presence and the concentration of nanoparticles in a given area, solution or region via cellular uptake and/or adsorption monitored through laboratory equipment. For example, the present invention provides a method of quantifying one or more nanoparticles by incubating a nanoparticle solution comprising one or more nanoparticles with one or more cells; isolating the one or more cells; lysing the one or more cells to release a cell lysate; separating the cell lysate electrophoretically on a gel; digitizing the gel to form a gel image; quantifying the nanoparticle intensity in the gel image; and correlating the nanoparticle intensity to a cell-associated nanoparticle concentration.
摘要翻译： 本发明提供用于通过实验室设备监测的细胞摄取和/或吸附来确定给定区域，溶液或区域中纳米颗粒的存在和浓度的方法，装置和试剂盒。 例如，本发明提供了通过将包含一种或多种纳米颗粒的纳米颗粒溶液与一种或多种细胞孵育来定量一种或多种纳米颗粒的方法; 隔离一个或多个细胞; 裂解一个或多个细胞以释放细胞裂解物; 在凝胶上电泳分离细胞裂解物; 将凝胶数字化以形成凝胶图像; 量化凝胶图像中的纳米颗粒强度; 并将纳米颗粒强度与细胞相关纳米颗粒浓度相关联。
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