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1.发明授权Antiulcer dihydrodibenzocycloheptyliden-ethylamine derivatives and process for the preparation of these compounds 失效抗溃疡二氢二苯并环庚烯二胺 - 乙胺衍生物及其制备方法
公开(公告)号：US4835179A
公开(公告)日：1989-05-30
申请号：US54409
申请日：1987-05-26
IPC分类号： C07D295/02 , A61K31/135 , A61K31/22 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/495 , A61K31/535 , A61K31/5375 , A61P1/04 , A61P9/08 , A61P11/00 , A61P25/24 , A61P25/26 , C07C67/00 , C07C209/00 , C07C209/08 , C07C211/32 , C07D207/32 , C07D207/335 , C07D211/26 , C07D213/38 , C07D213/74 , C07D241/04 , C07D295/03 , C07D295/073 , C07D295/088 , C07D295/10 , C07D295/104 , C07D295/108 , C07D295/112 , C07D295/12 , C07D295/15 , C07D295/18 , C07D295/185 , C07D295/192 , C07D295/205 , C07D295/215 , C07D307/14 , C07D307/52 , C07D317/52 , C07D317/58 , C07D333/20 , C07D401/06
CPC分类号： C07D207/335 , C07D211/26 , C07D213/38 , C07D213/74 , C07D241/04 , C07D295/03 , C07D295/073 , C07D295/088 , C07D295/104 , C07D295/108 , C07D295/112 , C07D295/15 , C07D295/185 , C07D295/192 , C07D295/205 , C07D295/215 , C07D307/52 , C07D317/52 , C07D317/58 , C07D333/20
摘要： Dihydrodibenzocycloheptyliden-ethylene derivatives of the general formula: ##STR1## in which, R.sub.1 represents an alkyl group having from 1 to 4 carbon atoms;R.sub.2 represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms; andR.sub.3 represents a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms or --CO--(C.sub.1 -C.sub.4 alkyl),are disclosed. These compounds are useful in the treatment of ulcer conditions.
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2.发明授权P-Chlorophenoxyacetic acid derivative, its method of preparation, the pharmaceutical compositions containing it and its use in medicine 失效对氯苯氧乙酸衍生物，其制备方法，含有它的药物组合物及其在医药中的应用
公开(公告)号：US4476319A
公开(公告)日：1984-10-09
申请号：US436960
申请日：1982-10-27
IPC分类号： A61K31/215 , A61K31/22 , A61P25/00 , A61P25/28 , C07C69/76 , C07C219/06
CPC分类号： C07C213/06 , C07C219/06 , C07C2103/74 , Y10S514/878
摘要： A new compound derived from p-chlorophenoxyacetic acid, the p-chlorophenocetate of 1-aminoadamantine-2-ethanol of the following structural formula I: ##STR1## as well as its pharmaceutically acceptable salts, possessing properties for the treatment of various pathological conditions of the central nervous system. Also disclosed are its method of preparation; pharmaceutical compositions containing the said compounds; and the treatment of various pathological conditions of the central nervous system with the use of the said compositions.
摘要翻译： 衍生自对氯苯氧基乙酸的新化合物，具有以下结构式I的1-氨基金刚烷-2-乙醇的对氯苯氧乙酸以及其药学上可接受的盐，具有用于治疗各种病理状况的性质 的中枢神经系统。 还公开了其制备方法; 含有所述化合物的药物组合物; 以及使用所述组合物治疗中枢神经系统的各种病理状况。
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公开(公告)号：US5112826A
公开(公告)日：1992-05-12
申请号：US336881
申请日：1989-04-12
IPC分类号： C07D295/02 , A61K31/135 , A61K31/22 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/495 , A61K31/535 , A61K31/5375 , A61P1/04 , A61P9/08 , A61P11/00 , A61P25/24 , A61P25/26 , C07C67/00 , C07C209/00 , C07C209/08 , C07C211/32 , C07D207/32 , C07D207/335 , C07D211/26 , C07D213/38 , C07D213/74 , C07D241/04 , C07D295/03 , C07D295/073 , C07D295/088 , C07D295/10 , C07D295/104 , C07D295/108 , C07D295/112 , C07D295/12 , C07D295/15 , C07D295/18 , C07D295/185 , C07D295/192 , C07D295/205 , C07D295/215 , C07D307/14 , C07D307/52 , C07D317/52 , C07D317/58 , C07D333/20 , C07D401/06
CPC分类号： C07D207/335 , C07D211/26 , C07D213/38 , C07D213/74 , C07D241/04 , C07D295/03 , C07D295/073 , C07D295/088 , C07D295/104 , C07D295/108 , C07D295/112 , C07D295/15 , C07D295/185 , C07D295/192 , C07D295/205 , C07D295/215 , C07D307/52 , C07D317/52 , C07D317/58 , C07D333/20
摘要： The dihydrodibenzocycloheptyliden-ethylpiperazine derivative has the formula: ##STR1## wherein R represents a substituent selected from the group consisting of --CH.dbd.CH.sub.2 ; --CO.sub.2 C.sub.2 H.sub.5 ; --CH.dbd.CH--CO.sub.2 CH.sub.3 ; ##STR2## and
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4.发明授权Vasodilatory dihydrodibenzocycloheptyliden-ethyl piperazine derivatives and process for the preparation of these compounds 失效血管扩张性二氢二苯并环庚烯 - 乙基哌嗪衍生物及其制备方法
公开(公告)号：US4835156A
公开(公告)日：1989-05-30
申请号：US54408
申请日：1987-05-26
IPC分类号： C07D295/02 , A61K31/135 , A61K31/22 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/495 , A61K31/535 , A61K31/5375 , A61P1/04 , A61P9/08 , A61P11/00 , A61P25/24 , A61P25/26 , C07C67/00 , C07C209/00 , C07C209/08 , C07C211/32 , C07D207/32 , C07D207/335 , C07D211/26 , C07D213/38 , C07D213/74 , C07D241/04 , C07D295/03 , C07D295/073 , C07D295/088 , C07D295/10 , C07D295/104 , C07D295/108 , C07D295/112 , C07D295/12 , C07D295/15 , C07D295/18 , C07D295/185 , C07D295/192 , C07D295/205 , C07D295/215 , C07D307/14 , C07D307/52 , C07D317/52 , C07D317/58 , C07D333/20 , C07D401/06
CPC分类号： C07D207/335 , C07D211/26 , C07D213/38 , C07D213/74 , C07D241/04 , C07D295/03 , C07D295/073 , C07D295/088 , C07D295/104 , C07D295/108 , C07D295/112 , C07D295/15 , C07D295/185 , C07D295/192 , C07D295/205 , C07D295/215 , C07D307/52 , C07D317/52 , C07D317/58 , C07D333/20
摘要： A dihydrodibenzocycloheptyliden-ethyl-piperazine derivative of the general formula: ##STR1## in which, R=--CH.dbd.CH.sub.2 ; --CH.sub.2 OH; --COOH; --CO.sub.2 C.sub.2 H.sub.5 ; --CH.dbd.CH--CO.sub.2 CH.sub.3 ; --CH.dbd.CH--CO.sub.2 CH.sub.3, --C.sub.6 H.sub.5, ##STR2## or pharmaceutically acceptable salts thereof, are disclosed. The compounds of the invention are useful in pharmaceutical compositions for the treatment of pathologies responsive to vasodilatory agents.
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