公开(公告)号：US4916150A

公开(公告)日：1990-04-10

申请号：US327228

申请日：1989-03-22

申请人： Denis M. Bailey ,  Ronald G. Powles

发明人： Denis M. Bailey ,  Ronald G. Powles

IPC分类号： A61K31/415 ,  A61K31/445 ,  A61P9/06 ,  C07C211/09 ,  C07D231/12 ,  C07D231/22 ,  C07D403/12

CPC分类号： C07D231/22

摘要： N-[alkylamino)alkyl]-3,4(or 4,5)-diaryl-1H-pyrazole-1-(branched)alkanamides and pyrazole-1-alkanamines useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine followed by reduction or by reacting the anion of a lower-alkyl ester of a pyrazole-1-acetic acid with an alkylating agent followed by displacement of the ester by an appropriate amine.

公开(公告)号：US4988725A

公开(公告)日：1991-01-29

申请号：US457989

申请日：1989-12-28

申请人： Denis M. Bailey ,  Ronald G. Powles

发明人： Denis M. Bailey ,  Ronald G. Powles

IPC分类号： C07D231/12 ,  C07D231/22

CPC分类号： C07D231/22

摘要： N-[(alkylamino)alkyl]-3,4(or 4,5)-diaryl-1H-pyrazole-1-(branched)alkanamides and pyrazole-1-alkanamines useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine followed by reduction or by reacting the anion of a lower-alkyl ester of a pyrazole-1-acetic acid with an alkylating agent followed by displacement of the ester by an appropriate amine.

摘要翻译： 可用于治疗哺乳动物心律失常的N - [（烷基氨基）烷基] -3,4（或4,5） - 二芳基-1H-吡唑-1-（支链）烷酰胺和吡唑-1-烷胺通过使 吡唑-1-乙酸的低级烷基酯与适当的二胺反应，然后还原或通过使吡唑-1-乙酸的低级烷基酯的阴离子与烷基化剂反应，然后将酯置换合适的 胺。