公开(公告)号：US06826488B1

公开(公告)日：2004-11-30

申请号：US09533466

申请日：2000-03-23

申请人： Frank R. Collart ,  Eliezer Huberman ,  Andrezej Joachimiak ,  Rongguang Zhang ,  Edwin M. Westbrook

发明人： Frank R. Collart ,  Eliezer Huberman ,  Andrezej Joachimiak ,  Rongguang Zhang ,  Edwin M. Westbrook

IPC分类号： G06F1900

CPC分类号： C12N9/0006 ,  C07K2299/00 ,  C12Y101/01205

摘要： The present invention relates to a data storage medium encoded with the structural coordinates of crystallized molecules and molecular complexes which comprise the active site binding pockets of bacterial IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes that comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of bacterial IMPDH.

摘要翻译： 本发明涉及用结构化分子和分子复合物的结构坐标编码的数据存储介质，其包含细菌IMPDH的活性位点结合口袋。 这样的数据存储材料能够在计算机屏幕上显示这样的分子和分子复合物或其结构同系物作为图形三维表示。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标来筛选和设计结合IMPDH或其同系物的化合物（包括抑制性化合物）的方法。 本发明还涉及包含IMPDH的活性位点结合袋或活性位点结合口袋的紧密结构同系物的分子和分子复合物。 本发明还涉及作为细菌IMPDH抑制剂的化合物和药物组合物。

公开(公告)号：US20090174682A1

公开(公告)日：2009-07-09

申请号：US12333166

申请日：2008-12-11

申请人： Upton Beall Bowden ,  Eric Marshall Knight ,  T. C. Wingrove ,  Henry Lee Pope ,  Yao H. Kuo ,  Xiaopei Huang ,  Robert Kelly Cadena ,  James Joseph Kornacki ,  Rongguang Zhang

发明人： Upton Beall Bowden ,  Eric Marshall Knight ,  T. C. Wingrove ,  Henry Lee Pope ,  Yao H. Kuo ,  Xiaopei Huang ,  Robert Kelly Cadena ,  James Joseph Kornacki ,  Rongguang Zhang

IPC分类号： G06F3/041 ,  B60Q1/00

CPC分类号： G06F3/04886 ,  B60K35/00 ,  B60K37/06 ,  B60K2370/154 ,  G06F3/0416

摘要： An instrumentation assembly for installation in a vehicle dashboard is disclosed herein. The instrumentation assembly includes an electronic controller, an enclosure, a viewable gauge, a viewable display, and a proximity-sensing switch. The controller has a memory for storing information. The enclosure has a designated front section and a designated rear section, wherein the front section includes substantially transparent material so as to define a window. Both the gauge and the display are electrically connected to the controller and mounted within the enclosure so as to substantially face the window. The switch is electrically connected to the controller and operable to sense the proximal presence of a human finger. In this configuration, the display is operable to exhibit the memory's information for viewing, and the switch is activatable by a human finger to selectively control the exhibition of the information on the display. Furthermore, an instrumentation module is also disclosed herein.

摘要翻译： 本文公开了一种用于安装在车辆仪表板中的仪表组件。 仪表组件包括电子控制器，外壳，可视测量计，可视显示器和接近感测开关。 控制器具有用于存储信息的存储器。 外壳具有指定的前部和指定的后部，其中前部包括基本上透明的材料以便限定窗口。 仪表和显示器都电连接到控制器并且安装在外壳内，以便基本上面对窗口。 开关电连接到控制器并且可操作以感测人类手指的近端存在。 在该配置中，显示器可操作以显示存储器的用于观看的信息，并且该开关可由人类手指激活以选择性地控制显示器上的信息展示。 此外，本文还公开了一种仪表模块。