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公开(公告)号:US06835731B2
公开(公告)日:2004-12-28
申请号:US09957654
申请日:2001-09-17
申请人: Gary Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis , Rosaria Maria Di Fluri
发明人: Gary Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis , Rosaria Maria Di Fluri
IPC分类号: A61K31541
CPC分类号: C07D213/38 , C07D213/65 , C07D213/81 , C07D215/40 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04
摘要: Tertiary amines containing a multiplicity of heteroaromatic substituents are useful as chemokine receptor modulators.
摘要翻译: 含有多个杂芳族取代基的叔胺可用作趋化因子受体调节剂。
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公开(公告)号:US06864265B2
公开(公告)日:2005-03-08
申请号:US09957682
申请日:2001-09-17
申请人: Gary Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. Mceachern , Bern Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis , Rosaria Maria Di Fluri
发明人: Gary Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. Mceachern , Bern Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis , Rosaria Maria Di Fluri
IPC分类号: C07D491/052 , A61K31/44 , A61K31/4402 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/506 , A61P31/18 , A61P43/00 , C07D213/38 , C07D213/65 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D493/04 , A61K31/4436 , C07D471/00
CPC分类号: C07D401/14 , C07D213/38 , C07D213/65 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D493/04
摘要: Compounds that bind to chemokine receptors such as CXCR4 and CCR5 demonstrate protective effects against infection of cells by human immunodeficiency virus are disclosed. These compounds contain a tertiary amine[[s]] linked to a core nitrogen via an aromatic or heteroaromatic moiety.
摘要翻译: 结合趋化因子受体如CXCR4和CCR5的化合物显示出针对人免疫缺陷病毒感染细胞的保护作用。 这些化合物含有通过芳族或杂芳族部分与核心氮连接的叔胺[[s]]。
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公开(公告)号:US06734191B2
公开(公告)日:2004-05-11
申请号:US10031812
申请日:2002-03-28
申请人: Gary Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. McEachern , Bern Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis , Rosaria Maria Di Fluri
发明人: Gary Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. McEachern , Bern Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis , Rosaria Maria Di Fluri
IPC分类号: C07D21548
CPC分类号: C07D213/81 , A61K31/4709 , C07D213/38 , C07D213/65 , C07D215/40 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04 , C07D493/04 , Y02A50/411
摘要: Compounds which modulate chemokine receptor activities are disclosed. These compounds are preferably tertiary amines comprising tetrahydroquinoline and benzimidazole.
摘要翻译: 公开了调节趋化因子受体活性的化合物。 这些化合物优选为包含四氢喹啉和苯并咪唑的叔胺。
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