公开(公告)号：US20190262479A1

公开(公告)日：2019-08-29

申请号：US16176658

申请日：2018-10-31

申请人： Stanley Satz ,  Roseanne Satz

发明人： Stanley Satz ,  Roseanne Satz

IPC分类号： A61K51/04

摘要： The present invention provides an in vivo imaging method that facilitates the diagnosis of Diffuse Intrinsic Pontine Glioma (DIPG) at an early stage. Early diagnosis is particularly advantageous as neuroprotective treatment can be applied to healthy neural cells to delay or even prevent the onset of debilitating clinical symptoms. The present invention also provides methods for producing an in vivo imaging agent useful for early diagnosis of DIPG, where embodiments of the imaging agent include a lipophilic azomycin-based hypoxic cell sensitizer labelled with an in vivo imaging moiety, and embodiments including [18F]FMISO as the lipophilic azomycin-based hypoxic cell sensitizer labelled with an in vivo imaging moiety.

公开(公告)号：US20190261858A1

公开(公告)日：2019-08-29

申请号：US16176352

申请日：2018-10-31

申请人： Stanley Satz ,  Roseanne Satz

发明人： Stanley Satz ,  Roseanne Satz

IPC分类号： A61B5/00 ,  A61K49/22 ,  A61B5/055 ,  A61B90/00

摘要： The present invention provides an in vivo imaging method that facilitates the diagnosis of Acute Lymphoblastic Leukemia (ALL) at an early stage. Early diagnosis is particularly advantageous as a tool to select more aggressive therapy, to estimate the success rate for visualizing ALL at the time of diagnosis.

公开(公告)号：US20220023639A1

公开(公告)日：2022-01-27

申请号：US17460512

申请日：2021-08-30

申请人： Olga Bockeria ,  Roseanne Satz

发明人： Olga Bockeria

IPC分类号： A61N1/368 ,  A61N1/372 ,  A61N1/378 ,  A61N1/05 ,  A61N1/375

摘要： A method, system and device for monitoring and treating conditions of a mammalian heart, among which may include bradyarrhythmias, tachyarrhythmias and heart failure, the device being configured as a pacemaker that harvests energy as it implements the pacemaker functions to treat and monitor conditions of the heart. The pacemaker has a case, electrical circuitry sealed within the case, an electrode that is electrically coupled to the electrical circuitry, and embodiments may include a microelectromechanical system (MEMS) for harvesting and converting the kinematic energy of the heart into electrical energy. Embodiments provide receivers at locations of the heart which sense heart activity and are controlled with pacing circuitry to deliver electrical impulses at locations and time intervals to replicate the contractions of a normal functioning heart. Further embodiments provide a multi-part pacemaker where case-connectable electrode part may be implanted separately from the case part.

公开(公告)号：US11103710B2

公开(公告)日：2021-08-31

申请号：US16430330

申请日：2019-06-03

申请人： Olga Bockeria ,  Roseanne Satz

发明人： Olga Bockeria

IPC分类号： A61N1/05 ,  A61N1/368 ,  A61N1/372 ,  A61N1/378 ,  A61N1/375

摘要： A method, system and device for monitoring and treating conditions of a mammalian heart, among which may include bradyarrhythmias, tachyarrhythmias and heart failure, the device being configured as a pacemaker that harvests energy as it implements the pacemaker functions to treat and monitor conditions of the heart. The pacemaker has a case, electrical circuitry sealed within the case, an electrode that is electrically coupled to the electrical circuitry, and embodiments may include a microelectromechanical system (MEMS) for harvesting and converting the kinematic energy of the heart into electrical energy. Embodiments provide receivers at locations of the heart which sense heart activity and are controlled with pacing circuitry to deliver electrical impulses at locations and time intervals to replicate the contractions of a normal functioning heart. Further embodiments provide a multi-part pacemaker where case-connectable electrode part may be implanted separately from the case part.