公开(公告)号：US20190262479A1

公开(公告)日：2019-08-29

申请号：US16176658

申请日：2018-10-31

申请人： Stanley Satz ,  Roseanne Satz

发明人： Stanley Satz ,  Roseanne Satz

IPC分类号： A61K51/04

摘要： The present invention provides an in vivo imaging method that facilitates the diagnosis of Diffuse Intrinsic Pontine Glioma (DIPG) at an early stage. Early diagnosis is particularly advantageous as neuroprotective treatment can be applied to healthy neural cells to delay or even prevent the onset of debilitating clinical symptoms. The present invention also provides methods for producing an in vivo imaging agent useful for early diagnosis of DIPG, where embodiments of the imaging agent include a lipophilic azomycin-based hypoxic cell sensitizer labelled with an in vivo imaging moiety, and embodiments including [18F]FMISO as the lipophilic azomycin-based hypoxic cell sensitizer labelled with an in vivo imaging moiety.

公开(公告)号：US20190261858A1

公开(公告)日：2019-08-29

申请号：US16176352

申请日：2018-10-31

申请人： Stanley Satz ,  Roseanne Satz

发明人： Stanley Satz ,  Roseanne Satz

IPC分类号： A61B5/00 ,  A61K49/22 ,  A61B5/055 ,  A61B90/00

摘要： The present invention provides an in vivo imaging method that facilitates the diagnosis of Acute Lymphoblastic Leukemia (ALL) at an early stage. Early diagnosis is particularly advantageous as a tool to select more aggressive therapy, to estimate the success rate for visualizing ALL at the time of diagnosis.