公开(公告)号：US20190262479A1

公开(公告)日：2019-08-29

申请号：US16176658

申请日：2018-10-31

申请人： Stanley Satz ,  Roseanne Satz

发明人： Stanley Satz ,  Roseanne Satz

IPC分类号： A61K51/04

摘要： The present invention provides an in vivo imaging method that facilitates the diagnosis of Diffuse Intrinsic Pontine Glioma (DIPG) at an early stage. Early diagnosis is particularly advantageous as neuroprotective treatment can be applied to healthy neural cells to delay or even prevent the onset of debilitating clinical symptoms. The present invention also provides methods for producing an in vivo imaging agent useful for early diagnosis of DIPG, where embodiments of the imaging agent include a lipophilic azomycin-based hypoxic cell sensitizer labelled with an in vivo imaging moiety, and embodiments including [18F]FMISO as the lipophilic azomycin-based hypoxic cell sensitizer labelled with an in vivo imaging moiety.

公开(公告)号：US20190261858A1

公开(公告)日：2019-08-29

申请号：US16176352

申请日：2018-10-31

申请人： Stanley Satz ,  Roseanne Satz

发明人： Stanley Satz ,  Roseanne Satz

IPC分类号： A61B5/00 ,  A61K49/22 ,  A61B5/055 ,  A61B90/00

摘要： The present invention provides an in vivo imaging method that facilitates the diagnosis of Acute Lymphoblastic Leukemia (ALL) at an early stage. Early diagnosis is particularly advantageous as a tool to select more aggressive therapy, to estimate the success rate for visualizing ALL at the time of diagnosis.

公开(公告)号：US06383217B1

公开(公告)日：2002-05-07

申请号：US09650290

申请日：2000-08-29

申请人： Stanley Satz

发明人： Stanley Satz

IPC分类号： A61F206

CPC分类号： A61K51/12 ,  A61K51/1282 ,  A61N5/1002

摘要： A metal stent for vascular implantation comprising a generally tubular structure whose external surface is adapted to engage the interior vascular surface when implanted, said metal of said stent containing a substantially uniform dispersion of from about 0.05 to about 10.00 percent by weight of one or more naturally occurring or enriched stable isotopes having a half-life of less than two months and that are principally beta particle emitters, so that when activated, said stent emits low to moderate dosages of radiation uniformly to reduce cell proliferation.

摘要翻译： 一种用于血管植入的金属支架，其包括大体上管状的结构，其外表面适于在植入时与内部血管表面接合，所述支架的所述金属含有基本均匀的分散体，其大约为一种或多种天然的约0.05至约10.00重量％ 发生或富集的半衰期小于两个月的稳定同位素，并且主要是β粒子发射体，使得当活化时，所述支架均匀地发射低至中等剂量的辐射以减少细胞增殖。

公开(公告)号：US06680993B2

公开(公告)日：2004-01-20

申请号：US09725017

申请日：2000-11-29

申请人： Stanley Satz ,  Scott Schenter

发明人： Stanley Satz ,  Scott Schenter

IPC分类号： G21G110

CPC分类号： G21G1/10

摘要： A method of producing an isotope comprising directing electrons at a converting material coated with a coating material, the coating material having an atomic number of n, whereby interaction of the electrons with the converting material produces photons, and whereby the photons produced interact with the coating material to produce an isotope having an atomic number of n−1. In preferred embodiments, the converting material is Tungsten, the coating material having an atomic number of n is Radium-226, and the isotope having an atomic number of n−1 is Radium-225.

摘要翻译： 一种生产同位素的方法，包括在涂覆有涂层材料的转化材料上引导电子，所述涂层材料具有原子数为n，由此电子与转化材料的相互作用产生光子，并且由此产生的光子与涂层相互作用 产生原子序数为n-1的同位素的材料。 在优选实施例中，转换材料为钨，原子序数为n的涂层材料为镭-226，原子序数为n-1的同位素为镭-225。

公开(公告)号：US06187037B1

公开(公告)日：2001-02-13

申请号：US09038560

申请日：1998-03-11

申请人： Stanley Satz

发明人： Stanley Satz

IPC分类号： A61F206

CPC分类号： A61K51/12 ,  A61K51/1282 ,  A61N5/1002

摘要： A metal stent for vascular implantation comprising a generally tubular structure whose external surface is adapted to engage the interior vascular surface when implanted, said metal of said stent containing a substantially uniform dispersion of from about 0.05 to about 10.00 percent by weight of one or more naturally occurring or enriched stable isotopes having a half-life of less than two months and that are principally beta particle emitters, so that when activated, said stent emits low to moderate dosages of radiation uniformly to reduce cell proliferation.

摘要翻译： 一种用于血管植入的金属支架，其包括大体上管状的结构，其外表面适于在植入时与内部血管表面接合，所述支架的所述金属含有基本均匀的分散体，其大约为一种或多种天然的约0.05至约10.00重量％ 发生或富集的半衰期小于两个月的稳定同位素，并且主要是β粒子发射体，使得当活化时，所述支架均匀地发射低至中等剂量的辐射以减少细胞增殖。

公开(公告)号：US06379380B1

公开(公告)日：2002-04-30

申请号：US09650151

申请日：2000-08-29

申请人： Stanley Satz

发明人： Stanley Satz

IPC分类号： A61F206

CPC分类号： A61K51/12 ,  A61K51/1282 ,  A61N5/1002

摘要： A metal stent for vascular implantation comprising a generally tubular structure whose extend surface is adapted to engage the interior vascular surface when implanted, said metal of said stent containing a substantially uniform dispersion of from about 0.05 to about 10.00 percent by weight of one or more naturally occurring or enriched stable isotopes having a half-life of less than two months and that are principally beta particle emitters, so that when activated, said stent emits low to moderate dosages of radiation uniformly to reduce cell proliferation.

摘要翻译： 一种用于血管植入的金属支架，其包括大体管状结构，其延伸表面适于在植入时与内部血管表面接合，所述支架的所述金属含有基本均匀的分散体，其大约为一种或多种天然的约0.05至约10.00重量％ 发生或富集的半衰期小于两个月的稳定同位素，并且主要是β粒子发射体，使得当活化时，所述支架均匀地发射低至中等剂量的辐射以减少细胞增殖。

公开(公告)号：US11357874B2

公开(公告)日：2022-06-14

申请号：US16568236

申请日：2019-09-11

申请人： Stanley Satz

发明人： Stanley Satz

IPC分类号： A61K51/10 ,  G01N33/574 ,  A61K51/08 ,  C07K16/22

摘要： Methods and compositions for treating, diagnosing and staging cancers, in particular overexpressing the Human Epidermal growth factor Receptor 2 protein (HER2+) given rise to in breast, gastric, gastroesophageal, ovarian, pancreatic cancer and brain tumors, which may be metastatic to the brain or other site. More specifically, the invention provides for Targeted Radionuclide Therapy (TRNT) with a compound of the invention having a peptide that targets the HER2+ cells, a second component for combining metals into complexes through a ring structure (DOTA), and a third radioisotope component, Lu-177 and Ga-68, in which embodiments further include a companion diagnostic, and in which embodiments further include anti-integrin precision medicines for cancers expressing αvβ3 and αvβ5 integrins, HER2+, vascular endothelial growth factor, vitronectin, fibronectin, tenascin, reelin, kindlin and talin. TRNT may be administered alone or in combination with standard-of-care; an immunooncologic and/or chemotherapeutic, adjuvantly or neoadjuvantly.

公开(公告)号：US20200085981A1

公开(公告)日：2020-03-19

申请号：US16568236

申请日：2019-09-11

申请人： Stanley Satz

发明人： Stanley Satz

IPC分类号： A61K51/10 ,  C07K16/22 ,  G01N33/574

摘要： Methods and compositions for treating, diagnosing and staging cancers, in particular overexpressing the Human Epidermal growth factor Receptor 2 protein (HER2+) given rise to in breast, gastric, gastroesophageal, ovarian, pancreatic cancer and brain tumors, which may be metastatic to the brain or other site. More specifically, the invention provides for Targeted Radionuclide Therapy (TRNT) with a compound of the invention having a peptide that targets the HER2+ cells, a second component for combining metals into complexes through a ring structure (DOTA), and a third radioisotope component, Lu-177 and Ga-68, in which embodiments further include a companion diagnostic, and in which embodiments further include anti-integrin precision medicines for cancers expressing αvβ3 and αvβ5 integrins, HER2+, vascular endothelial growth factor, vitronectin, fibronectin, tenascin, reelin, kindlin and talin. TRNT may be administered alone or in combination with standard-of-care; an immunooncologic and/or chemotherapeutic, adjuvantly or neoadjuvantly.

公开(公告)号：US20200085979A1

公开(公告)日：2020-03-19

申请号：US16568227

申请日：2019-09-11

申请人： Stanley Satz

发明人： Stanley Satz

IPC分类号： A61K51/08

摘要： The component ‘drug’ new molecule for combining metals into complexes through a ring structure (DOTA) or linear structure, and a radionuclidic component, and chelating agent wherein embodiments may include a companion diagnostic, and in which embodiments further include anti-integrin precision medicines for cancers expressing αvβ3 and αvβ5 integrins, second component for combining metals into complexes through a ring or linear structure, and one or more radionuclidic components, a chelating agent for diagnosis and/or therapy (theranostic) in which the embodiments further include a anti-integrin peptidomimetic for precision medicine for cancers expressing αvβ3 and αvβ5 integrins.

公开(公告)号：US06489617B1

公开(公告)日：2002-12-03

申请号：US09420313

申请日：1999-10-18

申请人： Darrell R. Fisher ,  David L. Alexander ,  Stanley Satz

发明人： Darrell R. Fisher ,  David L. Alexander ,  Stanley Satz

IPC分类号： G01T1164

CPC分类号： G21F5/02 ,  G21G4/06

摘要： Disclosed is a is an improved flood source, and method of making the same, which emits an evenly distributed flow of energy from a gamma emitting radionuclide dispersed throughout the volume of the flood source. The flood source is formed by filling a bottom pan with a mix of epoxy resin with cobalt-57, preferably at 10 to 20 millicuries and then adding a hardener. The pan is secured to a flat, level surface to prevent the pan from warping and to act as a heat sink for removal of heat from the pan during the curing of the resin-hardener mixture.

摘要翻译： 公开了一种改进的洪水源及其制造方法，其从分散在洪水源的整个体积中的伽马射线放射性核素发射均匀分布的能量流。 通过用环氧树脂与钴-57的混合物填充底盘形成洪水源，优选10至20毫升，然后加入硬化剂。 盘固定在平坦的水平表面上，以防止盘变形，并在树脂 - 固化剂混合物固化过程中作为散热片从锅中除去热量。