公开(公告)号：US20060045388A1

公开(公告)日：2006-03-02

申请号：US11218073

申请日：2005-08-31

申请人： Jack Zeineh ,  Rui-Tao Dong

发明人： Jack Zeineh ,  Rui-Tao Dong

IPC分类号： G06K9/20 ,  G06K9/36

CPC分类号： G02B21/365 ,  G02B21/367 ,  G02B27/0075 ,  G06T7/32 ,  G06T2200/32 ,  G06T2207/30004

摘要： Scanned image portions of a virtual slide are stored in accord with a positional index metric associated to each image's location in a mosaic representation of the entire physical slide and a normalized correlation search is performed on next neighbor regional image blocks. A set of relative positional offset values and a correlation coefficient is determined for a regional image block and a next neighbor regional image block. A portion of the regional image blocks is viewed as a field of view of a display and a composite of the portion of regional image blocks is stitched together in accord with the set of relative positional offset values and the correlation coefficient, such that only the blocks comprising the portion are stitched. Moving the field of view of the display causes additional regional image blocks to be displayed, where image stitching is subsequently performed only with respect to the additional regional image blocks brought into the new field of view.

摘要翻译： 根据与整个物理幻灯片的马赛克表示中的每个图像的位置相关联的位置索引度量来存储虚拟幻灯片的扫描图像部分，并且对下一个相邻区域图像块执行归一化的相关搜索。 针对区域图像块和下一个相邻区域图像块确定一组相对位置偏移值和相关系数。 区域图像块的一部分被视为显示器的视场，并且区域图像块的部分的合成根据相对位置偏移值和相关系数的集合被缝合在一起，使得仅仅块 包括该部分被缝合。 移动显示器的视野使得可以显示额外的区域图像块，其中随后仅对带入新视野的附加区域图像块执行图像拼接。

公开(公告)号：US08036868B2

公开(公告)日：2011-10-11

申请号：US12584831

申请日：2009-09-11

申请人： Jack A. Zeineh ,  Usman Rashid ,  Rui-Tao Dong

发明人： Jack A. Zeineh ,  Usman Rashid ,  Rui-Tao Dong

IPC分类号： G06G7/58

CPC分类号： G02B21/367 ,  G06T9/007

摘要： A method for creating a virtual slide is provided. A virtual slide is a digital representation of an area of interest of a microscopic slide. One method is to use a motorized microscope that can move a specimen with respect to a microscopic objective. With such a system, one can capture one or more images through a microscopic objective, such that a region of interest is imaged. Each image is then joined together to form a composite or “virtual image.” In one embodiment, after a virtual slide is created, a user may fully utilize the full capabilities of the remote microscope. Among these capabilities is a set of “optical objectives” and “virtual objectives.” Optical objectives are images created by digitizing an image through a microscopic objective in real time. Virtual objectives are digitally created magnifications created by utilizing the existing virtual slide data to digitally create a field of view.

摘要翻译： 提供了一种创建虚拟幻灯片的方法。 虚拟幻灯片是微观幻灯片的感兴趣区域的数字表示。 一种方法是使用可以相对于微观物镜移动样本的电动显微镜。 利用这样的系统，可以通过微观物镜捕获一个或多个图像，使得感兴趣的区域成像。 然后将每个图像连接在一起以形成复合或“虚拟图像”。在一个实施例中，在创建虚拟幻灯片之后，用户可以充分利用远程显微镜的全部功能。 这些功能包括一组“光学目标”和“虚拟目标”。光学目标是通过实时的微观目标对图像进行数字化创建的图像。 虚拟目标是通过利用现有虚拟幻灯片数据数字创建视野而创建的数字创建放大镜。

公开(公告)号：US20110187846A1

公开(公告)日：2011-08-04

申请号：US12958985

申请日：2010-12-02

申请人： Jack A. Zeineh ,  Usman Rashid ,  Rui-Tao Dong

发明人： Jack A. Zeineh ,  Usman Rashid ,  Rui-Tao Dong

IPC分类号： H04N7/18

CPC分类号： G02B21/367 ,  G06T9/007

摘要： A method for creating a virtual slide is provided. A virtual slide is a digital representation of an area of interest of a microscope slide. One method is to use a motorized microscope that can move a specimen with respect to a microscope objective. With such a system, one can capture one or more images through a microscope objective, such that a region of interest is imaged. Each image is then joined together to form a composite or “virtual image.” In one embodiment, after a virtual slide is created, a user may fully utilize the full capabilities of the remote microscope. Among these capabilities is a set of “optical objectives” and “virtual objectives.” Optical objectives are images created by digitizing an image through a microscope objective in real time. Virtual objectives are digitally created magnifications created by utilizing the existing virtual slide data to digitally create a field of view.

摘要翻译： 提供了一种创建虚拟幻灯片的方法。 虚拟幻灯片是显微镜幻灯片的感兴趣区域的数字表示。 一种方法是使用可以相对于显微镜物镜移动样本的电动显微镜。 利用这样的系统，可以通过显微镜物镜捕获一个或多个图像，使得感兴趣的区域成像。 然后将每个图像连接在一起以形成复合或“虚拟图像”。在一个实施例中，在创建虚拟幻灯片之后，用户可以充分利用远程显微镜的全部功能。 这些功能包括一组“光学目标”和“虚拟目标”。光学目标是通过实时显微镜物镜数字化图像而创建的图像。 虚拟目标是通过利用现有虚拟幻灯片数据数字创建视野而创建的数字创建放大镜。

公开(公告)号：US20060159367A1

公开(公告)日：2006-07-20

申请号：US11334138

申请日：2006-01-18

申请人： Jack Zeineh ,  Rui-Tao Dong

发明人： Jack Zeineh ,  Rui-Tao Dong

IPC分类号： G06K9/36 ,  G06K9/34 ,  G06K9/00

CPC分类号： G02B21/365 ,  G06F19/321 ,  G06K9/00134 ,  G06T7/0012 ,  G06T2207/30024 ,  G16H40/63

摘要： Systems and methods for creating variable quality images of a slide.

摘要翻译： 用于创建幻灯片的可变质量图像的系统和方法。

公开(公告)号：US20050089208A1

公开(公告)日：2005-04-28

申请号：US10897941

申请日：2004-07-22

申请人： Rui-Tao Dong ,  Usman Rashid ,  Jack Zeineh

发明人： Rui-Tao Dong ,  Usman Rashid ,  Jack Zeineh

IPC分类号： G02B21/24 ,  G02B21/36 ,  G06T3/40 ,  G06K9/00 ,  G06K9/40

CPC分类号： G06K9/00134 ,  G02B21/241 ,  G02B21/361 ,  G02B21/367 ,  G06T3/4038

摘要： An improved system and method for obtaining images of a microscope slide are provided. In one embodiment, a focus camera includes an optical sensor that is tilted relative to the focal plane of a scanning camera. A scan of a target region is performed, and multiple overlapping images of the target region are captured from a plurality of x-y positions. Each image contains information associated with multiple focal planes. Focus information is obtained from the images, and a desired-focus position is determined for the target region based on the focus information. The scanning camera then captures an image of the target region from the desired-focus position. This procedure may be repeated for selected regions on the microscope slide and the resulting images of the respective regions are merged to create a virtual slide.

摘要翻译： 提供了一种用于获得显微镜幻灯片的图像的改进的系统和方法。 在一个实施例中，焦点照相机包括相对于扫描照相机的焦平面倾斜的光学传感器。 执行目标区域的扫描，并且从多个x-y位置捕获目标区域的多个重叠图像。 每个图像包含与多个焦平面相关联的信息。 从图像获得焦点信息，并且基于焦点信息为目标区域确定期望焦点位置。 然后扫描照相机从所需对焦位置拍摄目标区域的图像。 可以对显微镜载片上的选定区域重复该过程，并且合并各个区域的所得图像以产生虚拟幻灯片。

公开(公告)号：US20060276974A1

公开(公告)日：2006-12-07

申请号：US11502816

申请日：2006-08-11

申请人： Jack Zeineh ,  Usman Rashid ,  Rui-Tao Dong

发明人： Jack Zeineh ,  Usman Rashid ,  Rui-Tao Dong

IPC分类号： G06F19/00 ,  G06K9/00

CPC分类号： G02B21/367 ,  G06T9/007

摘要： A method for creating a virtual slide is provided. A virtual slide is a digital representation of an area of interest of a microscope slide. One method is to use a motorized microscope that can move a specimen with respect to a microscope objective. With such a system, one can capture one or more images through a microscope objective, such that a region of interest is imaged. Each image is then joined together to form a composite or “virtual image.” In one embodiment, after a virtual slide is created, a user may fully utilize the full capabilities of the remote microscope. Among these capabilities is a set of “optical objectives” and “virtual objectives.” Optical objectives are images created by digitizing an image through a microscope objective in real time. Virtual objectives are digitally created magnifications created by utilizing the existing virtual slide data to digitally create a field of view.

摘要翻译： 提供了一种创建虚拟幻灯片的方法。 虚拟幻灯片是显微镜幻灯片的感兴趣区域的数字表示。 一种方法是使用可以相对于显微镜物镜移动样本的电动显微镜。 利用这样的系统，可以通过显微镜物镜捕获一个或多个图像，使得感兴趣的区域成像。 然后将每个图像连接在一起以形成复合或“虚拟图像”。 在一个实施例中，在创建虚拟幻灯片之后，用户可以充分利用远程显微镜的全部功能。 这些能力包括一套“光学目标”和“虚拟目标”。 光学目标是通过实时显微镜物镜数字化图像而创建的图像。 虚拟目标是通过利用现有虚拟幻灯片数据数字创建视野而创建的数字创建放大镜。

公开(公告)号：US07778485B2

公开(公告)日：2010-08-17

申请号：US11218073

申请日：2005-08-31

申请人： Jack A. Zeineh ,  Rui-Tao Dong

发明人： Jack A. Zeineh ,  Rui-Tao Dong

IPC分类号： G06K9/36

CPC分类号： G02B21/365 ,  G02B21/367 ,  G02B27/0075 ,  G06T7/32 ,  G06T2200/32 ,  G06T2207/30004

摘要： Scanned image portions of virtual slide are stored in accord with a positional index metric associated to each image's location in a mosaic representation of the entire physical slide and a normalized correlation search is performed on next neighbor regional image blocks. A set of relative positional offset values and a correlation coefficient is determined for a regional image block and a next neighbor regional image block. A portion of the regional image blocks is viewed as a field of view of a display and a composite of the potion of regional image blocks is stitched together in accord with the set of relative positional offset values and the correlation coefficient, such that only the blocks comprising the portion are stitched. Moving the field of view of the display causes additional regional image blocks to be displayed, where image stitching is subsequently performed only with respect to the additional regional image blocks brought into the new field of view.

摘要翻译： 根据与整个物理幻灯片的马赛克表示中的每个图像的位置相关联的位置索引度量来存储虚拟幻灯片的扫描图像部分，并且对下一个相邻区域图像块执行归一化相关搜索。 针对区域图像块和下一个相邻区域图像块确定一组相对位置偏移值和相关系数。 区域图像块的一部分被视为显示器的视场，并且根据相对位置偏移值和相关系数的集合将区域图像块的药水的组合拼接在一起，使得只有块 包括该部分被缝合。 移动显示器的视野使得可以显示额外的区域图像块，其中随后仅对带入新视野的附加区域图像块执行图像拼接。

公开(公告)号：US20100073472A1

公开(公告)日：2010-03-25

申请号：US12584831

申请日：2009-09-11

申请人： Jack A. Zeineh ,  Usman Rashid ,  Rui-Tao Dong

发明人： Jack A. Zeineh ,  Usman Rashid ,  Rui-Tao Dong

IPC分类号： H04N7/18 ,  G06K9/36

CPC分类号： G02B21/367 ,  G06T9/007

摘要： A method for creating a virtual slide is provided. A virtual slide is a digital representation of an area of interest of a microscopic slide. One method is to use a motorized microscope that can move a specimen with respect to a microscopic objective. With such a system, one can capture one or more images through a microscopic objective, such that a region of interest is imaged. Each image is then joined together to form a composite or “virtual image.” In one embodiment, after a virtual slide is created, a user may fully utilize the full capabilities of the remote microscope. Among these capabilities is a set of “optical objectives” and “virtual objectives.” Optical objectives are images created by digitizing an image through a microscopic objective in real time. Virtual objectives are digitally created magnifications created by utilizing the existing virtual slide data to digitally create a field of view.

摘要翻译： 提供了一种创建虚拟幻灯片的方法。 虚拟幻灯片是微观幻灯片的感兴趣区域的数字表示。 一种方法是使用可以相对于微观物镜移动样本的电动显微镜。 利用这样的系统，可以通过微观物镜捕获一个或多个图像，使得感兴趣的区域成像。 然后将每个图像连接在一起以形成复合或“虚拟图像”。在一个实施例中，在创建虚拟幻灯片之后，用户可以充分利用远程显微镜的全部功能。 这些功能包括一组“光学目标”和“虚拟目标”。光学目标是通过实时的微观目标对图像进行数字化创建的图像。 虚拟目标是通过利用现有虚拟幻灯片数据数字创建视野而创建的数字创建放大镜。

公开(公告)号：US20090074284A1

公开(公告)日：2009-03-19

申请号：US12277145

申请日：2008-11-24

申请人： Jack A. Zeineh ,  Rui-Tao Dong

发明人： Jack A. Zeineh ,  Rui-Tao Dong

IPC分类号： G06K9/00 ,  G02B27/64

CPC分类号： G02B21/365 ,  G02B21/367 ,  G02B27/0075 ,  G06T7/32 ,  G06T2200/32 ,  G06T2207/30004

摘要： A method and system for creating a digital, virtual slide having optimum image quality characteristics. Multiple regions of a physical slide are identified as well as at least two focus z-positions z1, and z2. Each region of the physical slide is scanned (imaged) at the first z position, so as to produce a first set of digital images of each defined region. Each region of the physical slide is also scanned (imaged) at the second z position, so as to produce a second set of digital images of each defined region. Each image of each set is evaluated against a focus quality metric and, for each region, either the first or second image, corresponding to that region, is selected that exhibits a focus quality metric corresponding to a desired focus quality. These images are then merged into a digital virtual slide. Additional focus z-positions may be included, and the multiple z-positions may be scanned seriatim, sequentially, and/or in overlapping fashion.

摘要翻译： 一种用于创建具有最佳图像质量特性的数字，虚拟幻灯片的方法和系统。 识别物理幻灯片的多个区域以及至少两个焦点z位置z1和z2。 在第一z位置扫描（成像）物理幻灯片的每个区域，以便产生每个限定区域的第一组数字图像。 物理幻灯片的每个区域也在第二z位置被扫描（成像），以便产生每个限定区域的第二组数字图像。 针对聚焦质量度量评估每组的每个图像，并且对于每个区域，选择对应于该区域的第一或第二图像，其呈现与期望焦点质量对应的焦点质量度量。 然后将这些图像合并到数字虚拟幻灯片中。 可以包括附加的焦点z位置，并且可以顺序，/或以重叠的方式扫描多个z位置。

公开(公告)号：US07456377B2

公开(公告)日：2008-11-25

申请号：US11211405

申请日：2005-08-25

申请人： Jack A. Zeineh ,  Rui-Tao Dong

发明人： Jack A. Zeineh ,  Rui-Tao Dong

IPC分类号： G02B7/04

CPC分类号： G02B21/365 ,  G02B21/367 ,  G02B27/0075 ,  G06T7/32 ,  G06T2200/32 ,  G06T2207/30004

摘要： A method and system for creating a digital, virtual slide having optimum image quality characteristics. Multiple regions of a physical slide are identified as well as at least two focus z-positions z1, and z2. Each region of the physical slide is scanned (imaged) at the first z position, so as to produce a first set of digital images of each defined region. Each region of the physical slide is also scanned (imaged) at the second z position, so as to produce a second set of digital images of each defined region. Each image of each set is evaluated against a focus quality metric and, for each region, either the first or second image, corresponding to that region, is selected that exhibits a focus quality metric corresponding to a desired focus quality. These images are then merged into a digital virtual slide. Additional focus z-positions may be included, and the multiple z-positions may be scanned seriatim, sequentially, and/or in overlapping fashion.

摘要翻译： 一种用于创建具有最佳图像质量特性的数字，虚拟幻灯片的方法和系统。 识别物理幻灯片的多个区域以及至少两个焦点z位置z 1和z 2。物理幻灯片的每个区域在第一z位置被扫描（成像），以便产生第一组 每个定义区域的数字图像。 物理幻灯片的每个区域也在第二z位置被扫描（成像），以便产生每个限定区域的第二组数字图像。 针对聚焦质量度量评估每组的每个图像，并且对于每个区域，选择对应于该区域的第一或第二图像，其呈现与期望焦点质量对应的焦点质量度量。 然后将这些图像合并到数字虚拟幻灯片中。 可以包括附加的焦点z位置，并且可以顺序，/或以重叠的方式扫描多个z位置。