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1.发明授权公开(公告)号：US08980320B2
公开(公告)日：2015-03-17
申请号：US13510050
申请日：2010-11-30
申请人： Ryoji Yoshii , Yuki Hayashi , Yuki Fujisaki
发明人： Ryoji Yoshii , Yuki Hayashi , Yuki Fujisaki
CPC分类号： A61K9/2813 , A61K9/2866
摘要： A film coating agent for a solid formulation includes a water-soluble cellulose derivative, swelling clay, a cationic surfactant, and a fatty acid, wherein mass ratio of the swelling clay to the water-soluble cellulose derivative is 2:8 to 8:2, and content of the cationic surfactant is not less than 0.5 equivalents and not more than 3.0 equivalents relative to a cation exchange equivalent of the swelling clay.
摘要翻译： 用于固体制剂的薄膜包衣剂包括水溶性纤维素衍生物，溶胀性粘土，阳离子表面活性剂和脂肪酸，其中溶胀性粘土与水溶性纤维素衍生物的质量比为2：8〜8：2 ，阳离子表面活性剂的含量相对于膨胀粘土的阳离子交换当量为不小于0.5当量且不大于3.0当量。
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2.发明授权公开(公告)号：US08920818B2
公开(公告)日：2014-12-30
申请号：US13141168
申请日：2009-12-25
申请人： Yuki Hayashi , Yuki Fujisaki , Ryoji Yoshii
发明人： Yuki Hayashi , Yuki Fujisaki , Ryoji Yoshii
CPC分类号： A61K47/02 , A61K9/2813 , A61K9/2826 , A61K9/284 , A61K47/32
摘要： A coating material for a solid formulation is capable of stably retaining the effective ingredient in the solid formulation for a prolonged period even in unpacked condition in such a manner that the solid formulation can be used in a single-dose formulation. The coating material for a solid formulation includes a high hydrogen-bonding resin and a swelling clay and, when coated on a solid formulation and dried, forms a coating film in which the laminated structures of the aforementioned swelling clay are oriented planarly and dispersed in a network fashion.
摘要翻译： 用于固体制剂的涂层材料即使在未包装的条件下也能够在固体制剂中稳定地保持固体制剂中的有效成分，使得固体制剂可以以单剂量制剂使用。 用于固体制剂的涂料包括高氢键树脂和膨胀粘土，并且当涂覆在固体制剂上并干燥时，形成涂膜，其中上述溶胀粘土的层压结构被平面取向并分散在 网络时尚。
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公开(公告)号：US08658208B2
公开(公告)日：2014-02-25
申请号：US13581010
申请日：2011-02-25
申请人： Yuki Fujisaki , Ryoji Yoshii , Yasuhide Horiuchi
发明人： Yuki Fujisaki , Ryoji Yoshii , Yasuhide Horiuchi
CPC分类号： A61K31/47 , A61K9/2813 , A61K9/284
摘要： A montelukast-containing coated solid preparation can be applied to one-dose package, wherein the humidity stability of montelukast or a pharmacologically acceptable salt thereof contained therein is maintained even when the preparation is unpacked. A coated solid preparation contains as an active ingredient montelukast or a pharmacologically acceptable salt thereof and is coated with a coating layer comprising polyvinyl alcohol and swelling clay, wherein the mass ratio of the above-described polyvinyl alcohol to the above-described swelling clay in the above-described coating layer is 8:2 to 3:7.
摘要翻译： 含有孟鲁司特的包衣固体制剂可以应用于一剂包装，其中即使在制剂解包时也保持其中所含的孟鲁司特或其药理学上可接受的盐的湿度稳定性。 涂布的固体制剂含有作为活性成分的孟鲁司特或其药理学上可接受的盐，并且涂覆有包含聚乙烯醇和溶胀性粘土的涂层，其中上述聚乙烯醇与上述溶胀粘土的质量比 上述涂层为8:2〜3:7。
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公开(公告)号：US06372755B1
公开(公告)日：2002-04-16
申请号：US09254650
申请日：1999-04-19
申请人： Nobuyuki Hanamura , Yasuhide Horiuchi , Ryoji Yoshii , Takao Aoki , Michio Hara
发明人： Nobuyuki Hanamura , Yasuhide Horiuchi , Ryoji Yoshii , Takao Aoki , Michio Hara
IPC分类号： A61K3144
摘要： A stable pharmaceutical composition includes a 4,5-epoxy-morphinan derivative, and includes at least one of the group consisting of a water soluble antioxidant, a fat soluble antioxidant, a synergist, a sugar, and a surfactant.
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公开(公告)号：US20120321677A1
公开(公告)日：2012-12-20
申请号：US13581010
申请日：2011-02-25
申请人： Yuki Fujisaki , Ryoji Yoshii , Yasuhide Horiuchi
发明人： Yuki Fujisaki , Ryoji Yoshii , Yasuhide Horiuchi
CPC分类号： A61K31/47 , A61K9/2813 , A61K9/284
摘要： A montelukast-containing coated solid preparation can be applied to one-dose package, wherein the humidity stability of montelukast or a pharmacologically acceptable salt thereof contained therein is maintained even when the preparation is unpacked. A coated solid preparation contains as an active ingredient montelukast or a pharmacologically acceptable salt thereof and is coated with a coating layer comprising polyvinyl alcohol and swelling clay, wherein the mass ratio of the above-described polyvinyl alcohol to the above-described swelling clay in the above-described coating layer is 8:2 to 3:7.
摘要翻译： 含有孟鲁司特的包衣固体制剂可以应用于一剂包装，其中即使在制剂解包时也保持其中所含的孟鲁司特或其药理学上可接受的盐的湿度稳定性。 涂布的固体制剂含有作为活性成分的孟鲁司特或其药理学上可接受的盐，并且涂覆有包含聚乙烯醇和溶胀性粘土的涂层，其中上述聚乙烯醇与上述溶胀粘土的质量比 上述涂层为8:2〜3:7。
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6.发明申请FILM COATING AGENT FOR SOLID PREPARATION, AND SOLID PREPARATION USING SAME 有权用于固体制剂的胶片涂料剂，以及使用该固化剂的固体制剂公开(公告)号：US20120237575A1
公开(公告)日：2012-09-20
申请号：US13510050
申请日：2010-11-30
申请人： Ryoji Yoshii , Yuki Hayashi , Yuki Fujisaki
发明人： Ryoji Yoshii , Yuki Hayashi , Yuki Fujisaki
CPC分类号： A61K9/2813 , A61K9/2866
摘要： A film coating agent for a solid formulation includes a water-soluble cellulose derivative, swelling clay, a cationic surfactant, and a fatty acid, wherein mass ratio of the swelling clay to the water-soluble cellulose derivative is 2:8 to 8:2, and content of the cationic surfactant is not less than 0.5 equivalents and not more than 3.0 equivalents relative to a cation exchange equivalent of the swelling clay.
摘要翻译： 用于固体制剂的薄膜包衣剂包括水溶性纤维素衍生物，溶胀性粘土，阳离子表面活性剂和脂肪酸，其中溶胀性粘土与水溶性纤维素衍生物的质量比为2：8〜8：2 ，阳离子表面活性剂的含量相对于膨胀粘土的阳离子交换当量为不小于0.5当量且不大于3.0当量。
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7.发明申请公开(公告)号：US20110256189A1
公开(公告)日：2011-10-20
申请号：US13141168
申请日：2009-12-25
申请人： Yuki Hayashi , Yuki Fujisaki , Ryoji Yoshii
发明人： Yuki Hayashi , Yuki Fujisaki , Ryoji Yoshii
IPC分类号： A61K9/00 , C08K5/1535 , C08K3/34
CPC分类号： A61K47/02 , A61K9/2813 , A61K9/2826 , A61K9/284 , A61K47/32
摘要： A coating material for a solid formulation is capable of stably retaining the effective ingredient in the solid formulation for a prolonged period even in unpacked condition in such a manner that the solid formulation can be used in a single-dose formulation. The coating material for a solid formulation includes a high hydrogen-bonding resin and a swelling clay and, when coated on a solid formulation and dried, forms a coating film in which the laminated structures of the aforementioned swelling clay are oriented planarly and dispersed in a network fashion.
摘要翻译： 用于固体制剂的涂层材料即使在未包装的条件下也能够在固体制剂中稳定地保持固体制剂中的有效成分，使得固体制剂可以以单剂量制剂使用。 用于固体制剂的涂料包括高氢键树脂和溶胀性粘土，当涂覆在固体制剂上并干燥时，形成涂膜，其中上述溶胀粘土的层压结构被平面取向并分散在 网络时尚。
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8.发明授权公开(公告)号：US09381248B2
公开(公告)日：2016-07-05
申请号：US13819523
申请日：2011-08-31
申请人： Yuki Fujisaki , Ryoji Yoshii , Suguru Takaki
发明人： Yuki Fujisaki , Ryoji Yoshii , Suguru Takaki
CPC分类号： A61K47/10 , A61K9/2813 , A61K9/2853 , A61K47/02
摘要： A coating agent for a pharmaceutical solid preparation imparts an unpackaged pharmaceutical solid preparation with excellent barrier properties equivalent to those of a PTP sheet without affecting the disintegration properties of the pharmaceutical solid preparation. The coating agent for a pharmaceutical solid preparation includes a polyethylene glycol having an average molecular weight of 950 to 25,000 and a swelling clay, wherein the mass ratio of the polyethylene glycol and the swelling clay is 2:8 to 6:4.
摘要翻译： 用于药物固体制剂的包衣剂赋予具有与PTP片剂相当的优异阻隔性能的未包装的药物固体制剂，而不影响药物固体制剂的崩解性能。 用于药物固体制剂的涂布剂包括平均分子量为950至25,000的聚乙二醇和溶胀性粘土，其中聚乙二醇和溶胀粘土的质量比为2:8至6:4。
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公开(公告)号：US08652521B2
公开(公告)日：2014-02-18
申请号：US13201546
申请日：2010-03-03
申请人： Yuki Hayashi , Ryoji Yoshii , Yasuhide Horiuchi
发明人： Yuki Hayashi , Ryoji Yoshii , Yasuhide Horiuchi
CPC分类号： A61K9/284 , A61K9/2813 , A61K31/19
摘要： A coated solid preparation includes an active ingredient including valproic acid or a pharmacologically acceptable salt thereof, and a coating layer containing polyvinyl alcohol and swelling clay coating the active ingredient wherein mass ratio of the polyvinyl alcohol to the swelling clay is 8:2 to 3:7 and the swelling clay is dispersed as a laminated structure.
摘要翻译： 包衣固体制剂包括包括丙戊酸或其药理学上可接受的盐的活性成分，以及包含聚乙烯醇和膨胀粘土的涂层，其中涂覆有活性成分，其中聚乙烯醇与膨胀粘土的质量比为8:2至3:1。 并且膨胀粘土作为层压结构分散。
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10.发明申请公开(公告)号：US20130156829A1
公开(公告)日：2013-06-20
申请号：US13819523
申请日：2011-08-31
申请人： Yuki Fujisaki , Ryoji Yoshii , Suguru Takaki
发明人： Yuki Fujisaki , Ryoji Yoshii , Suguru Takaki
CPC分类号： A61K47/10 , A61K9/2813 , A61K9/2853 , A61K47/02
摘要： A coating agent for a pharmaceutical solid preparation imparts an unpackaged pharmaceutical solid preparation with excellent barrier properties equivalent to those of a PTP sheet without affecting the disintegration properties of the pharmaceutical solid preparation. The coating agent for a pharmaceutical solid preparation includes a polyethylene glycol having an average molecular weight of 950 to 25,000 and a swelling clay, wherein the mass ratio of the polyethylene glycol and the swelling clay is 2:8 to 6:4.
摘要翻译： 用于药物固体制剂的包衣剂赋予具有与PTP片剂相当的优异阻隔性能的未包装的药物固体制剂，而不影响药物固体制剂的崩解性能。 用于药物固体制剂的涂布剂包括平均分子量为950至25,000的聚乙二醇和溶胀性粘土，其中聚乙二醇和溶胀粘土的质量比为2:8至6:4。
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