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公开(公告)号：US20140120631A1
公开(公告)日：2014-05-01
申请号：US14123665
申请日：2012-06-03
IPC分类号： G01N33/566
CPC分类号： G01N33/566 , G01N33/558 , G01N33/582 , G01N33/585 , G01N33/6896
摘要： A protein detection device and method. The device has a main channel in which is attached either a polar rail molecule or a biomolecular motor which moves on the rail molecule in a direction corresponding to the polarity of the rail molecule. A sub-channel crosses the main channel for receiving a sample including tau-protein. The method includes feeding the sample to the device and detecting a ratio of mutated tau-protein included in the sample, based on motion of the biomolecular motor on the rail molecule or on motion of the rail molecule moved by action of the biomolecular motor.
摘要翻译： 一种蛋白质检测装置及方法。 该装置具有主通道，其中连接有轨道分子在与轨道分子的极性相对应的方向上移动的极轨轨道分子或生物分子马达。 子通道穿过主通道以接收包含tau蛋白的样品。 该方法包括将样品进料到装置中，并基于轨道分子上的生物分子马达的运动或通过生物分子马达的作用移动的轨道分子的运动，检测样品中包含的突变的tau蛋白的比例。
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公开(公告)号：US20100076180A1
公开(公告)日：2010-03-25
申请号：US11919640
申请日：2005-11-21
申请人： Hiroyuki Fujita , Shoji Takeuchi , Ryuji Yokokawa
发明人： Hiroyuki Fujita , Shoji Takeuchi , Ryuji Yokokawa
CPC分类号： H02N11/006 , B82Y15/00 , F04B19/006 , F05B2250/84 , Y10S977/705
摘要： An object is to move a rail molecule by means of a biomolecular motor deposited on a base and inactivate the biomolecular motor through irradiation with light having a predetermined wavelength, to thereby readily and reliably fix the rail molecule at a predetermined position, while orienting the rail molecule in a predetermined direction without employment of any reagent. A method for fixing a rail molecule which has polarity and on which a biomolecular motor moves in a direction corresponding to the polarity includes depositing a biomolecular motor on a base; moving a rail molecule by means of the biomolecular motor; and inactivating the biomolecular motor by irradiating the biomolecular motor with light having a predetermined wavelength when the rail molecule reaches a predetermined position, to thereby fix the rail molecule so that it is oriented in a predetermined direction.
摘要翻译： 目的是通过沉积在基底上的生物分子马达来移动轨道分子，并通过用具有预定波长的光照射来灭活生物分子马达，从而容易且可靠地将轨道分子固定在预定位置，同时定向轨道 分子在预定方向上而不使用任何试剂。 固定具有极性的轨道分子的方法，其中生物分子马达在与极性相对应的方向上移动，包括在基底上沉积生物分子马达; 通过生物分子马达移动轨道分子; 并且当轨道分子到达预定位置时通过用具有预定波长的光照射生物分子马达来使生物分子马达失活，从而固定轨道分子使其沿预定方向取向。
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公开(公告)号：US20120070873A1
公开(公告)日：2012-03-22
申请号：US13307185
申请日：2011-11-30
申请人： Hiroyuki Fujita , Shoji Takeuchi , Ryuji Yokokawa
发明人： Hiroyuki Fujita , Shoji Takeuchi , Ryuji Yokokawa
IPC分类号： C12N13/00
CPC分类号： H02N11/006 , B82Y15/00 , F04B19/006 , F05B2250/84 , Y10S977/705
摘要： An object is to move a rail molecule by means of a biomolecular motor deposited on a base and inactivate the biomolecular motor through irradiation with light having a predetermined wavelength, to thereby readily and reliably fix the rail molecule at a predetermined position, while orienting the rail molecule in a predetermined direction without employment of any reagent. A method for fixing a rail molecule which has polarity and on which a biomolecular motor moves in a direction corresponding to the polarity includes depositing a biomolecular motor on a base; moving a rail molecule by means of the biomolecular motor; and inactivating the biomolecular motor by irradiating the biomolecular motor with light having a predetermined wavelength when the rail molecule reaches a predetermined position, to thereby fix the rail molecule so that it is oriented in a predetermined direction.
摘要翻译： 目的是通过沉积在基底上的生物分子马达来移动轨道分子，并通过用具有预定波长的光照射来灭活生物分子马达，从而容易且可靠地将轨道分子固定在预定位置，同时定向轨道 分子在预定方向上而不使用任何试剂。 固定具有极性的轨道分子的方法，其中生物分子马达在与极性相对应的方向上移动，包括在基底上沉积生物分子马达; 通过生物分子马达移动轨道分子; 并且当轨道分子到达预定位置时通过用具有预定波长的光照射生物分子马达来使生物分子马达失活，从而固定轨道分子使其沿预定方向取向。
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公开(公告)号：US08088739B2
公开(公告)日：2012-01-03
申请号：US11919640
申请日：2005-11-21
申请人： Hiroyuki Fujita , Shoji Takeuchi , Ryuji Yokokawa
发明人： Hiroyuki Fujita , Shoji Takeuchi , Ryuji Yokokawa
CPC分类号： H02N11/006 , B82Y15/00 , F04B19/006 , F05B2250/84 , Y10S977/705
摘要： An object is to move a rail molecule by means of a biomolecular motor deposited on a base and inactivate the biomolecular motor through irradiation with light having a predetermined wavelength, to thereby readily and reliably fix the rail molecule at a predetermined position, while orienting the rail molecule in a predetermined direction without employment of any reagent. A method for fixing a rail molecule which has polarity and on which a biomolecular motor moves in a direction corresponding to the polarity includes depositing a biomolecular motor on a base; moving a rail molecule by means of the biomolecular motor; and inactivating the biomolecular motor by irradiating the biomolecular motor with light having a predetermined wavelength when the rail molecule reaches a predetermined position, to thereby fix the rail molecule so that it is oriented in a predetermined direction.
摘要翻译： 目的是通过沉积在基底上的生物分子马达来移动轨道分子，并通过用具有预定波长的光照射来灭活生物分子马达，从而容易且可靠地将轨道分子固定在预定位置，同时定向轨道 分子在预定方向上而不使用任何试剂。 固定具有极性的轨道分子的方法，其中生物分子马达在与极性相对应的方向上移动，包括在基底上沉积生物分子马达; 通过生物分子马达移动轨道分子; 并且当轨道分子到达预定位置时通过用具有预定波长的光照射生物分子马达来使生物分子马达失活，从而固定轨道分子使其沿预定方向取向。
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