公开(公告)号：US20030054392A1

公开(公告)日：2003-03-20

申请号：US10228811

申请日：2002-08-27

申请人： SOFT GENE GMBH

发明人： Burghardt Wittig ,  Claas Junghans

IPC分类号： C12Q001/68 ,  C07H021/04

CPC分类号： C12N15/87 ,  A61K48/00 ,  Y10S977/916

摘要： The invention concerns an expressible nucleic acid construct, which contains only the sequence information necessary for expressing a gene for RNA or protein synthesis. Expression constructs of this type can be used in gene therapy and genetic vaccination and avoid many of the risks associated with constructs today. The invention further concerns the possibility of improving the conveying of the construct into cells or tissue by covalent linkage of the construct, for example to particles of peptides.

摘要翻译： 本发明涉及可表达的核酸构建体，其仅含有表达用于RNA或蛋白质合成的基因所必需的序列信息。 这种类型的表达构建体可用于基因治疗和基因疫苗接种，并避免今天与构建相关的许多风险。 本发明还涉及通过构建体的共价连接（例如与肽颗粒）将构建体转运到细胞或组织中的可能性。