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126 条记录 (耗时 0.038 秒)

    LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY
    1.
    发明申请
    LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY 有权
    低分子量阳离子脂肪酸用于寡核苷酸递送

    公开(公告)号：US20150284316A1

    公开(公告)日：2015-10-08

    申请号：US14681641

    申请日：2015-04-08

    申请人： Sirna Therapeutics, Inc.

    发明人： John A. BAWIEC, III ,  Zhengwu J. DENG

    IPC分类号： C07C217/08 ,  A61K9/51

    CPC分类号： C12N15/113 ,  A61K9/5123 ,  C07C217/08 ,  C07C2601/02 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32 ,  Y10S977/783 ,  Y10S977/916

    摘要： The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.

    摘要翻译： 本发明提供了可以与其它脂质组分如胆固醇和PEG-脂质组合使用以与寡核苷酸形成脂质纳米颗粒的新型阳离子脂质。 本发明的目的是提供一种阳离子脂质支架，由于肝中脂质水平降低，其表现出增强的功效以及较低的肝毒性。 本发明使用具有一个短脂链的低分子量阳离子脂质以增强siRNA的体内递送的效率和耐受性。

    Sterile aspiration/reinjection systems
    7.
    发明授权
    Sterile aspiration/reinjection systems 有权
    无菌抽吸/回注系统

    公开(公告)号：US06796957B2

    公开(公告)日：2004-09-28

    申请号：US10004525

    申请日：2001-10-23

    申请人： Kenneth W. Carpenter ,  Michelle Fourmont ,  E. Thomas Malphus ,  Kazuo Sasamine ,  Hong Li

    发明人： Kenneth W. Carpenter ,  Michelle Fourmont ,  E. Thomas Malphus ,  Kazuo Sasamine ,  Hong Li

    IPC分类号： A61M3100

    CPC分类号： A61M25/0084 ,  A61B2090/062 ,  A61M2025/0089 ,  A61M2202/0413 ,  A61M2205/75 ,  Y10S977/916 ,  A61M2202/0021

    摘要： The invention provides systems containing a sterile container for aspiration, filtering, treating and reinjection into a subject of a bodily fluid in a sterile environment. The systems are particularly designed to facilitate transfection of cells within the sterile container by gene therapy molecules and reinjection of the transfected cells into the donor at controlled depth in precisely controlled volumes such as is useful for revascularization of ischemic cardiac tissue. For injection, a pressure actuator, preferably hand-held, applies force to liquids held within the sterile container in precisely controlled increments, thereby expressing liquids through a hollow needle or injection catheter in precisely controlled microvolumes. The invention systems include a hand-held injection device with audible cues that correspond to an operator-selected injection volume and/or audible cues that correspond to needle penetration depth selected by the operator.

    摘要翻译： 本发明提供了包含用于在无菌环境中吸入，过滤，处理和再注入体液的受试者的无菌容器的系统。 该系统特别设计用于通过基因治疗分子促进无菌容器内的细胞的转染，并以受精的控制体积（例如对于缺血性心脏组织的血运重建有用）将被转染的细胞重新注入受控深度的供体。 对于注射，优选手持式压力致动器以精确控制的增量对保持在无菌容器内的液体施加力，从而通过中空针或注射导管在精确控制的微量体积中表达液体。 本发明系统包括手持式注射装置，其具有对应于操作者选择的注射体积和/或对应于由操作者选择的穿刺深度的可听到的线索的可听到的提示。

    Fullerene derivatives
    8.
    发明授权
    Fullerene derivatives 失效
    富勒烯衍生物

    公开(公告)号：US06765098B1

    公开(公告)日：2004-07-20

    申请号：US09622915

    申请日：2000-11-17

    申请人： Eiichi Nakamura ,  Masaya Sawamura ,  Hiroyuki Isobe

    发明人： Eiichi Nakamura ,  Masaya Sawamura ,  Hiroyuki Isobe

    IPC分类号： C07D23390

    CPC分类号： C12N15/87 ,  C07C229/16 ,  C07C2604/00 ,  Y10S977/734 ,  Y10S977/916

    摘要： A novel means for DNA compaction is provided. The object is accomplished by providing a fullerene derivative having 1 to 4 nitrogen-containing hydrophilic side chain(s) or its salt for DNA compaction. DNA compaction can be achieved effectively, and application to gene therapy is also expected.

    摘要翻译： 提供了一种用于DNA压实的新方法。目的是通过提供具有1〜4个含氮亲水侧链的富勒烯衍生物或其盐进行DNA压实，可以有效实现DNA的压实，并应用于基因治疗 也是预料之中。

    Arthroscopic irrigation solution and method for inhibition of pain and inflammation
    10.
    发明申请
    Arthroscopic irrigation solution and method for inhibition of pain and inflammation 失效
    关节镜灌洗液和抑制疼痛和炎症的方法

    公开(公告)号：US20030114355A1

    公开(公告)日：2003-06-19

    申请号：US10195625

    申请日：2002-07-12

    申请人： Omeros Medical Systems, Inc.

    发明人： Gregory A. Demopulos ,  Pamela A. Pierce ,  Jeffrey M. Herz

    IPC分类号： A61K031/00 ,  A61K031/485

    CPC分类号： A61K31/439 ,  A61K31/00 ,  A61K31/352 ,  A61K31/40 ,  A61K31/4045 ,  A61K31/4164 ,  A61K31/4168 ,  A61K31/4174 ,  A61K31/435 ,  A61K31/4406 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/48 ,  A61K31/498 ,  A61K31/505 ,  A61K31/506 ,  A61K31/538 ,  A61K45/06 ,  Y10S977/738 ,  Y10S977/904 ,  Y10S977/916 ,  Y10S977/919

    摘要： A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin1 antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin1 antagonist, a bradykinin2 antagonist and a null-opioid agonist.

    摘要翻译： 一种围手术期抑制来自一般外科手术（包括口腔/牙科手术）的伤口的各种疼痛和炎症过程的方法和解决方案。 该溶液优选包括在生理载体例如盐水或乳酸林格氏溶液中以稀释浓度抑制的多种疼痛和炎症。 在外科手术过程中连续冲洗伤口以解决疼痛的预防性作用，同时避免与口服，肌肉内，皮下或静脉内施用较大剂量的药剂相关的不良副作用。 抑制疼痛和炎症的一个优选的解决方案包括5-羟色胺2拮抗剂，5-羟色胺3拮抗剂，组胺拮抗剂，5-羟色胺激动剂，环加氧酶抑制剂，神经激肽1拮抗剂，神经激肽2拮抗剂，嘌呤受体拮抗剂，ATP-敏感钾通道开放剂， 钙通道拮抗剂，缓激肽1拮抗剂，缓激肽2拮抗剂和μ-阿片样物质激动剂。