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公开(公告)号:US09815901B2
公开(公告)日:2017-11-14
申请号:US14830392
申请日:2015-08-19
申请人: Jennifer Brogdon , Saar Gill , David Glass , Saad Kenderian , Andreas Loew , Joan Mannick , Michael C. Milone , Leon Murphy , David L. Porter , Marco Ruella , Yongqiang Wang , Qilong Wu , Jiquan Zhang
发明人: Jennifer Brogdon , Saar Gill , David Glass , Saad Kenderian , Andreas Loew , Joan Mannick , Michael C. Milone , Leon Murphy , David L. Porter , Marco Ruella , Yongqiang Wang , Qilong Wu , Jiquan Zhang
IPC分类号: C07K16/28 , C12N5/078 , C12N5/0783 , A61K39/00 , C07K16/24
CPC分类号: C07K16/2866 , A61K39/0011 , A61K2039/505 , A61K2039/507 , A61K2039/5156 , C07K16/244 , C07K2317/24 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/03 , C07K2319/33 , C12N5/0636
摘要: The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.
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2.
公开(公告)号:US20160051651A1
公开(公告)日:2016-02-25
申请号:US14805075
申请日:2015-07-21
申请人: Jennifer Brogdon , Hilmar Erhard Ebersbach , Saar Gill , David Glass , Julia Jascur , Saad Kenderian , Joan Mannick , Michael C. Milone , Leon Murphy , Celeste Richardson , Reshma Singh , Lai Wei , Qilong Wu , Qiumei Yang , Jiquan Zhang
发明人: Jennifer Brogdon , Hilmar Erhard Ebersbach , Saar Gill , David Glass , Julia Jascur , Saad Kenderian , Joan Mannick , Michael C. Milone , Leon Murphy , Celeste Richardson , Reshma Singh , Lai Wei , Qilong Wu , Qiumei Yang , Jiquan Zhang
IPC分类号: A61K39/00 , A61K31/7068 , C07K14/705 , A61K45/06 , C07K16/28 , C07K14/725
CPC分类号: A61K39/0011 , A61K31/7068 , A61K35/17 , A61K45/06 , A61K2039/5156 , C07K14/7051 , C07K14/70578 , C07K16/2851 , C07K2317/622 , C07K2319/02 , C07K2319/03
摘要: The invention provides compositions and methods for treating diseases associated with expression of CLL-1. The invention also relates to chimeric antigen receptor (CAR) specific to CLL-1, vectors encoding the same, and recombinant cells comprising the CLL-1 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CLL-1 binding domain.
摘要翻译: 本发明提供了治疗与CLL-1表达相关的疾病的组合物和方法。 本发明还涉及对CLL-1特异性的嵌合抗原受体(CAR),编码它的载体和包含CLL-1 CAR的重组细胞。 本发明还包括施用基因修饰的表达包含CLL-1结合结构域的CAR的细胞的方法。
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公开(公告)号:US20150283178A1
公开(公告)日:2015-10-08
申请号:US14680860
申请日:2015-04-07
申请人: Carl H. June , David L. Porter , Marcela Maus , Mariusz Wasik , Saar Gill , Joseph Fraietta , Marco Ruella , John Byrd , Jason Dubovsky , Amy Johnson , Natarajan Muthusamy , Saad Kenderian , Joan Mannick , David Glass , Leon Murphy , Jennifer Brogdon , William Raj Sellers
发明人: Carl H. June , David L. Porter , Marcela Maus , Mariusz Wasik , Saar Gill , Joseph Fraietta , Marco Ruella , John Byrd , Jason Dubovsky , Amy Johnson , Natarajan Muthusamy , Saad Kenderian , Joan Mannick , David Glass , Leon Murphy , Jennifer Brogdon , William Raj Sellers
IPC分类号: A61K35/17 , A61K31/519 , C07K16/30 , A61K31/53 , C07K14/725 , C07K16/28 , A61K31/436 , A61K39/395 , A61K45/06
CPC分类号: A61K35/17 , A61K31/436 , A61K31/519 , A61K31/53 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/5156 , A61K2039/5158 , C07K14/7051 , C07K16/2803 , C07K2317/14 , C07K2317/24 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2319/03 , C12N5/0636 , C12N2501/599 , C12N2501/727 , C12N2510/00 , A61K2300/00
摘要: The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a kinase inhibitor, e.g., a kinase inhibitor described herein. The invention also provides kits and compositions described herein.
摘要翻译: 本发明提供了用于治疗与CD19表达相关的疾病的组合物和方法,例如通过如本文所述施用包含本文所述的CD19 CAR的重组T细胞与激酶抑制剂,例如本文所述的激酶抑制剂组合。 本发明还提供了本文所述的试剂盒和组合物。
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4.
公开(公告)号:US20190336504A1
公开(公告)日:2019-11-07
申请号:US16317943
申请日:2017-07-14
申请人: Saar Gill , Saad Kenderian , Marco Ruella , Novartis AG , The Trustees of the University of Pennsylvania
发明人: Saar Gill , Saad Kenderian , Marco Ruella
IPC分类号: A61K31/519 , A61P37/02 , A61K39/395 , A61K35/17 , A61P35/00
摘要: The disclosure provides compositions and methods for treating diseases associated with expression of an antigen or for treating or prevent cytokine release syndrome, e.g., by administering a CAR therapy with a kinase inhibitor, e.g., JAK-STAT inhibitor and/or BTK inhibitor.
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公开(公告)号:US20160096892A1
公开(公告)日:2016-04-07
申请号:US14805236
申请日:2015-07-21
申请人: Jennifer Brogdon , Hilmar Erhard Ebersbach , Saar Gill , David Glass , Thomas Huber , Julia Jascur , Saad Kenderian , Joan Mannick , Michael C. Milone , Leon Murphy , Celeste Richardson , Reshma Singh , Huijuan Song , Qilong Wu , Jiquan Zhang
发明人: Jennifer Brogdon , Hilmar Erhard Ebersbach , Saar Gill , David Glass , Thomas Huber , Julia Jascur , Saad Kenderian , Joan Mannick , Michael C. Milone , Leon Murphy , Celeste Richardson , Reshma Singh , Huijuan Song , Qilong Wu , Jiquan Zhang
IPC分类号: C07K16/28 , C07K14/725 , A61K45/06 , C07K14/705 , A61K38/17 , A61K39/395 , C07K16/30 , C07K14/715
CPC分类号: C07K16/2851 , A61K31/436 , A61K31/711 , A61K35/28 , A61K38/00 , A61K38/1774 , A61K38/1793 , A61K39/39558 , A61K45/06 , A61K48/00 , A61K2039/505 , A61K2039/5156 , C07K14/7051 , C07K14/70517 , C07K14/7056 , C07K14/70578 , C07K14/7151 , C07K16/2803 , C07K16/30 , C07K16/3061 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/03 , C07K2319/33 , C07K2319/70 , A61K2300/00
摘要: The invention provides compositions and methods for treating diseases associated with expression of CD33. The invention also relates to chimeric antigen receptor (CAR) specific to CD33, vectors encoding the same, and recombinant T cells comprising the CD33 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD33 binding domain.
摘要翻译: 本发明提供用于治疗与CD33表达相关的疾病的组合物和方法。 本发明还涉及对CD33特异性的嵌合抗原受体(CAR),编码它的载体和包含CD33 CAR的重组T细胞。 本发明还包括施用表达包含CD33结合结构域的CAR的遗传修饰的T细胞的方法。
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公开(公告)号:US20160068601A1
公开(公告)日:2016-03-10
申请号:US14830392
申请日:2015-08-19
申请人: Jennifer Brogdon , Saar Gill , David Glass , Saad Kenderian , Andreas Loew , Joan Mannick , Michael C. Milone , Leon Murphy , David L. Porter , Marco Ruella , Yongqiang Wang , Qilong Wu , Jiquan Zhang
发明人: Jennifer Brogdon , Saar Gill , David Glass , Saad Kenderian , Andreas Loew , Joan Mannick , Michael C. Milone , Leon Murphy , David L. Porter , Marco Ruella , Yongqiang Wang , Qilong Wu , Jiquan Zhang
CPC分类号: C07K16/2866 , A61K39/0011 , A61K2039/505 , A61K2039/507 , A61K2039/5156 , C07K16/244 , C07K2317/24 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/03 , C07K2319/33 , C12N5/0636
摘要: The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.
摘要翻译: 本发明提供用于治疗与CD123表达相关的疾病的组合物和方法。 本发明还涉及对CD123特异性的嵌合抗原受体(CAR),编码它的载体和包含CD123 CAR的重组细胞。 本发明还包括施用表达包含CD123结合结构域的CAR的遗传修饰的细胞的方法。
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