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    Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
    8.
    发明授权
    Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool 有权
    作为研究工具，使用工程多价信号平台激活和扩展T细胞

    公开(公告)号：US07745140B2

    公开(公告)日：2010-06-29

    申请号：US10461283

    申请日：2003-06-13

    申请人： Carl June ,  James Riley ,  Marcela Maus ,  Anna Thomas ,  Robert Vonderheide

    发明人： Carl June ,  James Riley ,  Marcela Maus ,  Anna Thomas ,  Robert Vonderheide

    IPC分类号： G01N33/53 ,  C12N5/00 ,  C12N15/63 ,  C07K17/00

    CPC分类号： C12N5/0636 ,  A61K35/17 ,  A61K2039/5158 ,  C07K14/70535 ,  C12N5/0634 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2501/599 ,  C12N2502/99 ,  C12N2510/00 ,  C12N2510/04

    摘要： Provided are a system and methods for selectively inducing expansion of a population of T cells in the absence of exogenous growth factors, such as lymphokines, and accessory cells for research purposes. The cell based expansion system and methods permit the long-term growth of CTLs, preferably human CTLs. In addition, T cell proliferation can be induced without the need for antigen, thus providing an expanded T cell population that is polyclonal with respect to antigen reactivity. Further provided are methods for using the system and methods to screen and identify antigens related to specific diseases or conditions, tumors, autoimmune disorders, or an infectious disease or pathogen, and to identify target molecule for research purposes, or for developing a vaccine based thereon.

    摘要翻译： 提供了一种系统和方法，用于在没有外源性生长因子（例如淋巴因子）和用于研究目的的辅助细胞的情况下选择性诱导T细胞群的扩增。 基于细胞的扩增系统和方法允许CTL的长期生长，优选人CTL。 此外，可以在不需要抗原的情况下诱导T细胞增殖，从而提供关于抗原反应性的多克隆的扩增T细胞群。 进一步提供的是使用该系统和方法来筛选和鉴定与特定疾病或病症，肿瘤，自身免疫性疾病或感染性疾病或病原体相关的抗原的方法，并鉴定用于研究目的的靶分子或基于其开发疫苗 。