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    Cynara scolymus extracts, the use thereof and formulations containing them
    1.
    发明申请
    Cynara scolymus extracts, the use thereof and formulations containing them 审中-公开
    Cynara scolymus提取物，其使用和含有它们的制剂

    公开(公告)号：US20090285911A1

    公开(公告)日：2009-11-19

    申请号：US11988638

    申请日：2006-06-16

    申请人： Ezio Bombardelli ,  Gabriele Fontana ,  Andrea Giori ,  Paolo Morazzoni ,  Massimo Ronchi ,  Sabrina Arpini

    发明人： Ezio Bombardelli ,  Gabriele Fontana ,  Andrea Giori ,  Paolo Morazzoni ,  Massimo Ronchi ,  Sabrina Arpini

    IPC分类号： A61K36/28 ,  A61K31/343 ,  A61P3/00 ,  A61P1/00 ,  A61P9/10

    CPC分类号： A61K36/28 ,  A61K36/185 ,  A61K36/55 ,  A61K2300/00

    摘要： The present invention relates to the preparation of a Cynara scolymus extract obtainable by fractioning on a resin. The process of the invention allows to obtain an extract, starting from the aerial parts of the plant Cynara scolymus, containing three classes of active principles, namely dicaffeoylquinic acids, luteolin and cynaropicrin glycosides, in a constant ratio. Cynaropicrin is stabilized by addition of precise amounts of sulfated amino acids or suitable thio-derivatives. These extracts have hypolipemizing, anti-dyspeptic and vascular anti-inflammatory activities. The extracts are mainly formulated in Enothera biennis oil or in oils rich in ω-3 and ω-6 acids which enhance the vascular activity.

    摘要翻译： 本发明涉及通过在树脂上分馏获得的Cynara scolymus提取物的制备。 本发明的方法允许以恒定比例从植物Cynara scolymus的地上部分开始，含有三类活性成分，即二茶醛奎宁酸，木犀草素和猕猴桃糖苷。 通过添加精确量的硫酸化氨基酸或合适的硫代衍生物来稳定辛酰丙酸。 这些提取物具有降血脂，消化不良和血管消炎活性。 提取物主要配制在Enothera biennis油或富含ω-3和ω-6酸的油中，从而增强血管活性。

    Process for removing pesticides from ginkgo biloba extracts, and extracts obtainable by said process
    3.
    发明授权
    Process for removing pesticides from ginkgo biloba extracts, and extracts obtainable by said process 有权
    从银杏提取物中除去农药的方法，以及通过所述方法得到的提取物

    公开(公告)号：US09504270B2

    公开(公告)日：2016-11-29

    申请号：US13258715

    申请日：2010-03-31

    申请人： Andrea Giori ,  Giacomo Mombelli ,  Sabrina Arpini ,  Mario Acerbi

    发明人： Andrea Giori ,  Giacomo Mombelli ,  Sabrina Arpini ,  Mario Acerbi

    IPC分类号： A61K36/16 ,  A23L1/015

    摘要： Process for removing pesticides from Ginkgo biloba extracts, which involves submitting an extract obtained by conventional methods to the following steps: a. Liquid-liquid extraction of the extract to obtain a medium polarity fraction containing ginkgo terpenes and pesticides not removable with hexane, and a high polarity fraction containing ginkgo flavone glycosides; b. crystallization from the medium polarity fraction obtained at step a) to give an intermediate with a ginkgolide content of not less than 50%; c. crystallization from the residual solution obtained at step b) to give an intermediate with a bilobalide content of not less than 50%; d. mixing of the high polarity fraction obtained at step a) with the ginkgo terpene intermediate and the bilobalide intermediate obtained at steps b) and c).

    摘要翻译： 从银杏提取物中除去农药的方法，涉及将通过常规方法获得的提取物提交到以下步骤：a。 液体提取提取物，得到含有银杏萜烯和农药的中性极性馏分，不能用己烷除去;高极性馏分含有银杏黄酮苷; b。 从步骤a）获得的中等极性级分结晶，得到银杏内酯含量不小于50％的中间体; C。 从步骤b）获得的残留溶液中结晶，得到银杏内酯含量不小于50％的中间体; d。 将步骤a）获得的高极性级分与在步骤b）和c）获得的银杏萜中间体和双内酰亚胺中间体混合。

    PROCESS FOR REMOVING PESTICIDES FROM GINKGO BILOBA EXTRACTS, AND EXTRACTS OBTAINABLE BY SAID PROCESS
    5.
    发明申请
    PROCESS FOR REMOVING PESTICIDES FROM GINKGO BILOBA EXTRACTS, AND EXTRACTS OBTAINABLE BY SAID PROCESS 审中-公开
    从银杏叶提取物中除去杀虫剂的方法，以及通过上述方法获得的提取物

    公开(公告)号：US20120100232A1

    公开(公告)日：2012-04-26

    申请号：US13258715

    申请日：2010-03-31

    申请人： Andrea Giori ,  Giacomo Mombelli ,  Sabrina Arpini ,  Mario Acerbi

    发明人： Andrea Giori ,  Giacomo Mombelli ,  Sabrina Arpini ,  Mario Acerbi

    IPC分类号： A61K36/16

    CPC分类号： A61K36/16 ,  A23L5/23 ,  A61K2236/35 ,  A61K2236/53 ,  B01D9/00 ,  B01D11/0492

    摘要： Process for removing pesticides from Ginkgo biloba extracts, which involves submitting an extract obtained by conventional methods to the following steps:a. Liquid-liquid extraction of the extract to obtain a medium polarity fraction containing ginkgo terpenes and pesticides not removable with hexane, and a high polarity fraction containing ginkgo flavone glycosides;b. crystallisation from the medium polarity fraction obtained at step a) to give an intermediate with a ginkgolide content of not less than 50%;c. crystallisation from the residual solution obtained at step b) to give an intermediate with a bilobalide content of not less than 50%;d. mixing of the high polarity fraction obtained at step a) with the ginkgo terpene intermediate and the bilobalide intermediate obtained at steps b) and c).

    摘要翻译： 从银杏提取物中除去农药的方法，涉及将通过常规方法获得的提取物提交到以下步骤：a。 液体提取提取物，得到含有银杏萜烯和农药的中性极性馏分，不能用己烷除去;高极性馏分含有银杏黄酮苷; b。 从步骤a）获得的中等极性级分结晶，得到银杏内酯含量不小于50％的中间体; C。 从步骤b）获得的残留溶液中结晶，得到银杏内酯含量不小于50％的中间体; d。 将步骤a）获得的高极性级分与在步骤b）和c）获得的银杏萜中间体和双内酰亚胺中间体混合。