公开(公告)号：US4670261A

公开(公告)日：1987-06-02

申请号：US779444

申请日：1985-09-24

申请人： Masayoshi Samejima ,  Saburo Matsuda ,  Toshio Wakabayashi ,  Naoki Hayakawa

发明人： Masayoshi Samejima ,  Saburo Matsuda ,  Toshio Wakabayashi ,  Naoki Hayakawa

IPC分类号： A61K9/08 ,  A23L1/304 ,  A23L1/305 ,  A61K31/195 ,  A61K31/40 ,  A61K31/405 ,  A61K31/415 ,  A61K31/70 ,  A61K33/00 ,  A61K38/00 ,  A61K38/01 ,  A61K33/06 ,  A61K33/14

CPC分类号： A61K33/00 ,  A23L33/16 ,  A23L33/175 ,  A61K38/01

摘要： A parenteral alimentation solution having excellent nutritional properties with preventing problems such as browning which comprises three components of a reducing sugar, amino acids and electrolytes in a specific composition and a specific amount.

摘要翻译： 具有优异营养特性的肠胃外营养液，具有防止诸如褐变的问题，其包含具有特定组成的还原糖，氨基酸和电解质的三种组分和特定量。

公开(公告)号：US5650172A

公开(公告)日：1997-07-22

申请号：US479143

申请日：1995-06-07

申请人： Saburo Matsuda ,  Shigeyuki Ishikawa ,  Akira Suzuki ,  Kenji Tsujihara ,  Motoaki Ohashi

发明人： Saburo Matsuda ,  Shigeyuki Ishikawa ,  Akira Suzuki ,  Kenji Tsujihara ,  Motoaki Ohashi

IPC分类号： A61K9/107 ,  A61K9/14 ,  A61K9/19 ,  A61K47/12 ,  A61K47/18 ,  A61K47/26 ,  A61K9/10 ,  A61K9/16

CPC分类号： A61K9/14 ,  A61K9/1075 ,  A61K9/19 ,  Y10S514/937 ,  Y10S514/938

摘要： A preparation comprising a fat emulsion of fat microparticles wherein said emulsion contains a stabilizer consisting essentially of a fatty acid, a basic amino acid and a saccharide is provided. In the preparation comprising a fat emulsion of fat microparticles of the present invention, said microparticles having a mean particle diameter of at most 100 nm are stable, and so the microparticles remain in blood without being uptaken by liver. Therefore in case of administering a pharmaceutical preparation prepared by using the above-mentioned preparation of the present invention, the pharmacological activity may be expressed at a desired site. Thus the preparation is extremely useful as a drug carrier for drug delivery system. Furthermore, the pharmaceutical preparation of the present invention which is lyophilized can be easily and rapidly reconstituted into the pharmaceutical preparation comprising a fat emulsion of stable fat microparticles having a mean particle diameter of about at most 100 nm by adding distilled water, even after a long-term storage.

摘要翻译： 提供了包含脂肪微粒的脂肪乳液的制剂，其中所述乳液含有基本上由脂肪酸，碱性氨基酸和糖组成的稳定剂。 在包含本发明的脂肪微粒的脂肪乳剂的制剂中，平均粒径为100nm以下的微粒是稳定的，因此微粒保留在血液中而不被肝吸收。 因此，在施用通过使用本发明的上述制剂制备的药物的情况下，可以在期望的部位表达药理活性。 因此，该制剂作为药物递送系统的药物载体非常有用。 此外，冻干的本发明的药物制剂可以通过添加蒸馏水容易且迅速地重构成包含平均粒径为大约100nm的稳定脂肪微粒的脂肪乳剂的药物制剂，即使经过长时间 -term存储。

公开(公告)号：US5767123A

公开(公告)日：1998-06-16

申请号：US559100

申请日：1995-11-16

申请人： Masanori Yoshida ,  Saburo Matsuda ,  Chie Tomioka

发明人： Masanori Yoshida ,  Saburo Matsuda ,  Chie Tomioka

IPC分类号： A61K9/08 ,  A23L1/302 ,  A23L1/305 ,  A61K31/195 ,  A61K31/198 ,  A61K31/51 ,  A61K31/70 ,  A61K45/06 ,  A61P3/00 ,  A61P3/12 ,  A01N43/78

CPC分类号： A61K45/06 ,  A23L33/15 ,  A23L33/175 ,  A23V2002/00

摘要： A TPN solution to be prepared before using which comprises two separate infusions of an amino acid-infusion and a saccharide-infusion wherein both of said infusions contain no sulfite ion, either one of said infusions contains a water-soluble vitamin B, a pH of the infusion containing a water-soluble vitamin B is acidic and a pH of the TPN solution prepared by mixing both infusions is neutral. According to the TPN solution of the present invention, a water-soluble vitamin B can be stably preserved in a TPN solution for a long term though it has been recognized that the water-soluble vitamin B could not be contained in a TPN solution. The present invention enables to practically use a TPN solution previously containing a water-soluble vitamin B.

摘要翻译： 在使用之前要制备的TPN溶液包含氨基酸输注和糖输注的两个单独的输注，其中所述输注都不含亚硫酸根离子，所述输注中的任一种含有水溶性维生素B，pH为 含有水溶性维生素B的输液是酸性的，通过混合两种输液制备的TPN溶液的pH是中性的。 根据本发明的TPN溶液，尽管已经认识到在TPN溶液中不能含有水溶性维生素B，水溶性维生素B可长期稳定地保存在TPN溶液中。 本发明能够实际使用先前含有水溶性维生素B的TPN溶液。

公开(公告)号：US4016100A

公开(公告)日：1977-04-05

申请号：US652212

申请日：1976-01-26

申请人： Akira Suzuki ,  Hiroshi Miura ,  Saburo Matsuda ,  Takashi Ohsawa

发明人： Akira Suzuki ,  Hiroshi Miura ,  Saburo Matsuda ,  Takashi Ohsawa

IPC分类号： A61K9/107 ,  A61K9/127 ,  B01J13/02 ,  A61K9/52

CPC分类号： A61K9/1278 ,  A61K9/1277 ,  Y10T428/2984

摘要： A pharmaceutical composition is prepared by the steps of dispersing a phospholipid uniformly in water to give an aqueous phospholipid dispersion, adding a medicament to the aqueous dispersion, freezing the thus-obtained aqueous dispersion, thereby entrapping the medicament in the lipid spherules, and then thawing the frozen dispersion to give an aqueous suspension of the medicament entrapped in the lipid spherules having a diameter of less than 5.0 .mu.. The pharmaceutical composition prepared above is used as a controlled release pharmaceutical preparation.

摘要翻译： 通过以下步骤制备药物组合物：将磷脂均匀地分散在水中，得到磷脂水分散体，向水分散体中加入药物，冷冻由此得到的水分散体，从而将药物截留在脂质球中，然后解冻 冷冻分散体，得到截留在直径小于5.0μm的脂质球的药物的水性悬浮液。 将上述制备的药物组合物用作控释药物制剂。