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    COMPOSITION FOR ENHANCING TRANSDERMAL ABSORPTION OF A DRUG AND PATCH PREPARATION
    2.
    发明申请
    COMPOSITION FOR ENHANCING TRANSDERMAL ABSORPTION OF A DRUG AND PATCH PREPARATION 有权
    用于增强药物和配制物的超吸收的组合物

    公开(公告)号：US20130064868A1

    公开(公告)日：2013-03-14

    申请号：US13611154

    申请日：2012-09-12

    申请人： Arimichi OKAZAKI ,  Tsuyoshi MUKOBATA ,  Sachiko SAKAMOTO ,  Akinori HANATANI

    发明人： Arimichi OKAZAKI ,  Tsuyoshi MUKOBATA ,  Sachiko SAKAMOTO ,  Akinori HANATANI

    IPC分类号： A61K47/10 ,  A61K9/00 ,  A61K47/18

    CPC分类号： A61K9/7038 ,  A61K9/0014 ,  A61K9/7084 ,  A61K31/405 ,  A61K31/41 ,  A61K31/422 ,  A61K31/565

    摘要： The problem of the present invention is to provide a composition for enhancing transdermal absorption of a drug, which shows a sufficiently high enhancing effect on transdermal absorption of a drug, particularly, a composition for enhancing transdermal absorption of a drug, which shows a sufficiently high enhancing effect on transdermal absorption of an acidic drug.A composition for enhancing transdermal absorption of a drug, comprising an unsaturated higher alcohol having 12-20 carbon atoms and a polyvalent alcohol having 3-8 carbon atoms. A composition for enhancing transdermal absorption of a drug, comprising an unsaturated higher alcohol having 12-20 carbon atoms, a polyvalent alcohol having 3-8 carbon atoms and an organic amine having 2-9 carbon atoms.

    摘要翻译： 本发明的问题是提供一种用于增强药物经皮吸收的组合物，其对药物的经皮吸收具有足够高的增强效果，特别是用于增强药物经皮吸收的组合物，其显示出足够高的 增强对酸性药物经皮吸收的作用。 一种用于增强药物透皮吸收的组合物，其包含具有12-20个碳原子的不饱和高级醇和具有3-8个碳原子的多元醇。 一种用于增强药物透皮吸收的组合物，其包含具有12-20个碳原子的不饱和高级醇，具有3-8个碳原子的多元醇和具有2-9个碳原子的有机胺。

    ADHESIVE PATCH AND PATCH PREPARATION
    3.
    发明申请
    ADHESIVE PATCH AND PATCH PREPARATION 审中-公开
    胶粘剂和配方的制备

    公开(公告)号：US20120027840A1

    公开(公告)日：2012-02-02

    申请号：US13190767

    申请日：2011-07-26

    申请人： Akinori HANATANI ,  Sachiko SAKAMOTO ,  Arimichi OKAZAKI ,  Hitoshi AKEMI

    发明人： Akinori HANATANI ,  Sachiko SAKAMOTO ,  Arimichi OKAZAKI ,  Hitoshi AKEMI

    IPC分类号： A61K9/70 ,  B32B7/12

    CPC分类号： A61L15/58 ,  Y10T428/28

    摘要： The present invention provides an adhesive patch including a backing and a pressure-sensitive adhesive layer formed on at least one surface of the backing, in which (a) a surface of the pressure-sensitive adhesive layer has a logarithmic decrement, as determined by the rigid-pendulum free-damped oscillation method, in the range of 0.03 to 0.35, and (b) the pressure-sensitive adhesive layer has a maximum shear displacement in the range of 18 μm to 1,000 μm. The present invention further provides a patch preparation containing a drug. The adhesive patch and the patch preparation according to the present invention are reduced in skin irritation during wear.

    摘要翻译： 本发明提供了一种粘合贴片，其包括背衬和形成在背衬的至少一个表面上的压敏粘合剂层，其中（a）压敏粘合剂层的表面具有对数递减，如 刚性摆摆动阻尼振荡法，在0.03〜0.35的范围内，（b）压敏粘合剂层的最大剪切位移在18μm〜1000μm的范围内。 本发明还提供含有药物的贴片制剂。 根据本发明的粘合贴剂和贴剂制剂在穿着期间减少皮肤刺激。

    PATCH PREPARATION AND PRODUCTION METHOD THEREOF
    4.
    发明申请
    PATCH PREPARATION AND PRODUCTION METHOD THEREOF 审中-公开
    PATCH制备及其生产方法

    公开(公告)号：US20110243998A1

    公开(公告)日：2011-10-06

    申请号：US13074911

    申请日：2011-03-29

    申请人： Sachiko SAKAMOTO ,  Akinori Hanatani ,  Arimichi Okazaki ,  Hitoshi Akemi ,  Yoshihiro Iwao ,  Kensuke Matsuoka

    发明人： Sachiko SAKAMOTO ,  Akinori Hanatani ,  Arimichi Okazaki ,  Hitoshi Akemi ,  Yoshihiro Iwao ,  Kensuke Matsuoka

    IPC分类号： A61K9/00 ,  A61K31/445 ,  A61K31/4174 ,  A61K31/34 ,  A61K31/192 ,  A61K31/195 ,  A61K31/4152 ,  A61K31/46

    CPC分类号： A61K9/7061 ,  A61K9/7053

    摘要： The invention provides a patch preparation containing (a) a support and (b) an adhesive layer containing a drug on the surface of the support, wherein a crystal of the drug is formed in the adhesive layer immediately after application of a physical stimulation to the adhesive layer, while a crystal of the drug is formed during preservation after the physical stimulation. The patch preparation which does not require an increase in the area and thickness of an adhesive layer, achieves a sufficiently high skin permeation amount of the drug, shows good adhesiveness to skin, and permits a long-term adhesion to skin. The invention also provides a method of producing the patch preparation.

    摘要翻译： 本发明提供了一种补片制剂，其包含（a）支持物和（b）在载体表面上含有药物的粘合剂层，其中在施加物理刺激之后立即在粘合剂层中形成药物的晶体 而在物理刺激后的保存期间形成药物的晶体。 不需要增加粘合剂层的面积和厚度的贴片制剂能够获得足够高的皮肤渗透量的药物，对皮肤具有良好的粘附性，并且可以长期粘附到皮肤上。 本发明还提供一种制备贴剂的方法。

    COMPOSITION FOR ENHANCING TRANSDERMAL ABSORPTION OF A DRUG AND PATCH PREPARATION
    7.
    发明申请
    COMPOSITION FOR ENHANCING TRANSDERMAL ABSORPTION OF A DRUG AND PATCH PREPARATION 审中-公开
    用于增强药物和配制物的超吸收的组合物

    公开(公告)号：US20130064869A1

    公开(公告)日：2013-03-14

    申请号：US13611179

    申请日：2012-09-12

    申请人： Arimichi Okazaki ,  Tsuyoshi Mukobata ,  Sachiko Sakamoto ,  Akinori Hanatani

    发明人： Arimichi Okazaki ,  Tsuyoshi Mukobata ,  Sachiko Sakamoto ,  Akinori Hanatani

    IPC分类号： A61K47/10 ,  A61K9/00

    CPC分类号： A61K9/7061 ,  A61K31/405 ,  Y02A50/481

    摘要： The problem of the present invention is to provide a composition which shows a sufficiently high enhancing effect on transdermal absorption of a drug, particularly, a composition which shows a sufficiently high enhancing effect on transdermal absorption of a drug in a patch preparation.A composition for enhancing transdermal absorption of a drug of a patch preparation, containing a higher alcohol having 14-20 carbon atoms and a polyvalent alcohol having 3-8 carbon atoms.

    摘要翻译： 本发明的问题在于提供一种组合物，该组合物对药物的透皮吸收具有足够高的增强效果，特别是对贴剂制剂中的药物的经皮吸收具有足够高的增强效果的组合物。 一种用于增强贴剂的药物透皮吸收的组合物，其包含具有14-20个碳原子的高级醇和具有3-8个碳原子的多元醇。