公开(公告)号：US20130210166A1

公开(公告)日：2013-08-15

申请号：US13703520

申请日：2011-06-10

申请人： Sakari Kulmala ,  Antti Niskanen ,  Aija Kulmala ,  Kari Loikas ,  Matti Pusa

发明人： Sakari Kulmala ,  Antti Niskanen ,  Aija Kulmala ,  Kari Loikas ,  Matti Pusa

IPC分类号： G01N21/66

CPC分类号： G01N27/3276 ,  G01N21/66 ,  G01N27/327

摘要： The invention relates to electrode chip (EChip) cartridge devices which are used in hot electron -induced electro-chemiluminescence (HECL) and electroluminescence (EL) methods and instrumentation based on the electrical excitation of label molecules with subsequent measurement of the luminescence in order to quantitate analyte concentrations in bioaffinity assays, especially outside of central laboratories, but also in rapid screening tests.

摘要翻译： 本发明涉及用于热电子诱导的电化学发光（HECL）和电致发光（EL）方法的电极芯片（EChip）盒装置，并且基于标记分子的电激发，随后测量发光，以便 定量生物亲和测定中的分析物浓度，特别是在中央实验室外，而且在快速筛选测试中。

公开(公告)号：US20130206610A1

公开(公告)日：2013-08-15

申请号：US13703393

申请日：2011-06-10

申请人： Sakari Kulmala ,  Timo Kalevi Korpela ,  Jarkko Uolevi Eskola ,  Johanna Suomi ,  Markus Hakansson ,  Teppo Tapani Laaksonen

发明人： Sakari Kulmala ,  Timo Kalevi Korpela ,  Jarkko Uolevi Eskola ,  Johanna Suomi ,  Markus Hakansson ,  Teppo Tapani Laaksonen

IPC分类号： G01N27/327

CPC分类号： G01N27/3276 ,  G01N21/66 ,  G01N27/327

摘要： Electrochemiluminescent technique and device suitable for cheap analytical and diagnostic applications, with electrodes manufactured from carbon paste and terbium chelates as labeling compounds.

公开(公告)号：US09377433B2

公开(公告)日：2016-06-28

申请号：US13703418

申请日：2011-06-10

申请人： Sakari Kulmala ,  Antti Niskanen ,  Samuli Franssila ,  Tiina Ylinen-Hinkka

发明人： Sakari Kulmala ,  Antti Niskanen ,  Samuli Franssila ,  Tiina Ylinen-Hinkka

IPC分类号： G01N21/66 ,  G01N27/327

CPC分类号： G01N27/3276 ,  G01N21/66 ,  G01N27/327

摘要： The invention relates to integrated electronic chip (IEChip) cartridge devices which are used in hot electron-induced electrochemiluminescence methods and to instrumentation based on the electrical excitation of label molecules with subsequent measurement of luminescence in order to quantitate analyte concentrations especially in bioaffinity assays, especially outside of central laboratories.

摘要翻译： 本发明涉及用于热电子诱导电化学发光方法的集成电子芯片（IEChip）芯片装置和基于标记分子的电激发的仪器，随后测量发光，以便定量分析物浓度，特别是在生物亲和力测定中 在中央实验室外。

公开(公告)号：US20130206611A1

公开(公告)日：2013-08-15

申请号：US13703418

申请日：2011-06-10

申请人： Sakari Kulmala ,  Antti Niskanen ,  Samuli Franssila ,  Tiina Ylinen-Hinkka

发明人： Sakari Kulmala ,  Antti Niskanen ,  Samuli Franssila ,  Tiina Ylinen-Hinkka

IPC分类号： G01N21/66

CPC分类号： G01N27/3276 ,  G01N21/66 ,  G01N27/327

摘要： The invention relates to integrated electronic chip (lEChip) cartridge devices which are used in hot electron-induced electrochemiluminescence methods and to instrumentation based on the electrical excitation of label molecules with subsequent measurement of luminescence in order to quantitate analyte concentrations especially in bioaffinity assays, especially outside of central laboratories.

摘要翻译： 本发明涉及用于热电子诱导电化学发光方法的集成电子芯片（IEChip）芯片装置和基于标记分子的电激发的仪器，随后测量发光，以定量分析物浓度，特别是在生物亲和力测定中 在中央实验室外。

公开(公告)号：US20060096866A1

公开(公告)日：2006-05-11

申请号：US11293187

申请日：2005-12-05

申请人： Timo Ala-Kleme ,  Philip Canty ,  Jarkko Eskola ,  Timo Korpela ,  Sakari Kulmala ,  Piia Vainio

发明人： Timo Ala-Kleme ,  Philip Canty ,  Jarkko Eskola ,  Timo Korpela ,  Sakari Kulmala ,  Piia Vainio

IPC分类号： C25D5/02 ,  H01L21/288 ,  C25D5/00

CPC分类号： G01N21/76 ,  G01N21/66 ,  Y10S435/968 ,  Y10S436/805 ,  Y10S436/806

摘要： Methods and insulator electrode devices for performing electrochemical reactions are disclosed. The devices consist of high specific surface area electrodes based on a channeled conducting base material that has been coated with an organic or inorganic insulating film or multiple layers of such films. The chemical reactions are exemplified by exciting one or several label compounds into an excited state which is spontaneously de-excited by emission of ultraviolet, visible or infrared light, in aqueous solution. This provides the basis for reproducible analytical applications in bioaffinity assays such as immunoassays and DNA-probing assays.

公开(公告)号：US07005108B2

公开(公告)日：2006-02-28

申请号：US10128571

申请日：2002-04-24

申请人： Timo Ala-Kleme ,  Philip Canty ,  Jarkko Eskola ,  Timo Korpela ,  Sakari Kulmala ,  Piia Vainio

发明人： Timo Ala-Kleme ,  Philip Canty ,  Jarkko Eskola ,  Timo Korpela ,  Sakari Kulmala ,  Piia Vainio

IPC分类号： G01N21/29

CPC分类号： G01N21/76 ,  G01N21/66 ,  Y10S435/968 ,  Y10S436/805 ,  Y10S436/806

摘要： Methods and insulator electrode devices for performing electrochemical reactions are disclosed. The devices consist of high specific surface area electrodes based on a channeled conducting base material that has been coated with an organic or inorganic insulating film or multiple layers of such films. The chemical reactions are exemplified by exciting one or several label compounds into an excited state which is spontaneously de-excited by emission of ultraviolet, visible or infrared light, in aqueous solution. This provides the basis for reproducible analytical applications in bioaffinity assays such as immunoassays and DNA-probing assays.

公开(公告)号：US09535029B2

公开(公告)日：2017-01-03

申请号：US13703520

申请日：2011-06-10

申请人： Sakari Kulmala ,  Antti Niskanen ,  Aija Kulmala ,  Kari Loikas ,  Matti Pusa

发明人： Sakari Kulmala ,  Antti Niskanen ,  Aija Kulmala ,  Kari Loikas ,  Matti Pusa

IPC分类号： G01N21/66 ,  G01N27/327

CPC分类号： G01N27/3276 ,  G01N21/66 ,  G01N27/327

摘要： The invention relates to electrode chip (EChip) cartridge devices which are used in hot electron-induced electro-chemiluminescence (HECL) and electroluminescence (EL) methods and instrumentation based on the electrical excitation of label molecules with subsequent measurement of the luminescence in order to quantitate analyte concentrations in bioaffinity assays, especially outside of central laboratories, but also in rapid screening tests.

摘要翻译： 本发明涉及用于热电子诱导电化学发光（HECL）和电致发光（EL）方法的电极芯片（EChip）盒装置，并且基于标记分子的电激发，随后测量发光，以便 定量生物亲和测定中的分析物浓度，特别是在中央实验室外，还可以进行快速筛选测试。

公开(公告)号：US08920718B2

公开(公告)日：2014-12-30

申请号：US13703453

申请日：2011-06-10

申请人： Sakari Kulmala ,  Timo Kalevi Korpela ,  Jarkko Uolevi Eskola ,  Teppo Tapani Laaksonen

发明人： Sakari Kulmala ,  Timo Kalevi Korpela ,  Jarkko Uolevi Eskola ,  Teppo Tapani Laaksonen

IPC分类号： G01N27/327 ,  G01N21/66

CPC分类号： G01N27/3276 ,  G01N21/66

摘要： The invention describes novel chemiluminescence electrode devices and their novel properties to enable achieving luminescence signal by electrical excitation by cathodic or bipolar pulses in aqueous electrolyte solutions. These devices form a significant improvement in construction of cheap and reliable means for especially diagnosis of health conditions in point-of-need purposes.

摘要翻译： 本发明描述了新颖的化学发光电极装置及其新颖的性质，以便能够通过在电解质水溶液中阴极或双极脉冲的电激发来实现发光信号。 这些装置在建立廉价和可靠的手段方面进行了重大改进，用于特别诊断需要点目的的健康状况。

公开(公告)号：US07513983B2

公开(公告)日：2009-04-07

申请号：US11293187

申请日：2005-12-05

申请人： Timo Ala-Kleme ,  Philip Canty ,  Jarkko Eskola ,  Timo Korpela ,  Sakari Kulmala ,  Piia Vainio

发明人： Timo Ala-Kleme ,  Philip Canty ,  Jarkko Eskola ,  Timo Korpela ,  Sakari Kulmala ,  Piia Vainio

IPC分类号： G01N27/26

CPC分类号： G01N21/76 ,  G01N21/66 ,  Y10S435/968 ,  Y10S436/805 ,  Y10S436/806

摘要： Methods and insulator electrode devices for performing electrochemical reactions are disclosed. The devices consist of high specific surface area electrodes based on a channeled conducting base material that has been coated with an organic or inorganic insulating film or multiple layers of such films. The chemical reactions are exemplified by exciting one or several label compounds into an excited state which is spontaneously de-excited by emission of ultraviolet, visible or infrared light, in aqueous solution. This provides the basis for reproducible analytical applications in bioaffinity assays such as immunoassays and DNA-probing assays.

摘要翻译： 公开了用于进行电化学反应的方法和绝缘体电极装置。 这些装置由基于导电基材的高比表面积电极组成，其已涂覆有机或无机绝缘膜或多层这种膜。 化学反应的例子是将一种或几种标记化合物激发成激发态，其通过在水溶液中发射紫外线，可见光或红外光而自发地去激发。 这为生物亲和力测定中的可重复分析应用提供了基础，如免疫测定和DNA探针测定。

公开(公告)号：US06645776B2

公开(公告)日：2003-11-11

申请号：US09779881

申请日：2001-02-09

申请人： Sakari Kulmala ,  Timo Ala-Kleme ,  Jarkko Eskola ,  Timo Korpela

发明人： Sakari Kulmala ,  Timo Ala-Kleme ,  Jarkko Eskola ,  Timo Korpela

IPC分类号： G01N33543

CPC分类号： G01N21/76 ,  G01N21/66 ,  G01N33/5438 ,  Y10S435/968 ,  Y10S436/805 ,  Y10S436/806 ,  Y10S436/816

摘要： The excitation of label molecules usable in chemical and biochemical analysis by electrical pulses at electrodes covered with a thin insulating film, and the use of such electrodes in chemical, clinical and biochemical analysis. The electrodes include a conducting base material that has been coated with an organic or inorganic insulating film or multiple layers of such films, so that either one or several label compounds can be excited to an excited state which is deexcited by emission of ultraviolet, visible or infrared light, in aqueous solution providing the basis for reproducible analytical applications in bioaffinity assays such as immunoassays and DNA-probing assays.