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公开(公告)号:US08101605B2
公开(公告)日:2012-01-24
申请号:US12960318
申请日:2010-12-03
申请人: Lloyd Mackenzie , Tom MacRury , Curtis Harwig , Jeremy Pettigrew , Noor Aini Bhatti , Sam Place , Paul Bird , Vladimir Khlebnikov , Rudong Shan
发明人: Lloyd Mackenzie , Tom MacRury , Curtis Harwig , Jeremy Pettigrew , Noor Aini Bhatti , Sam Place , Paul Bird , Vladimir Khlebnikov , Rudong Shan
IPC分类号: C07D311/78 , C07D335/04 , A61K31/352 , A61K31/382
CPC分类号: C07D335/04 , C07D311/78 , C07D409/06
摘要: Compounds of structure (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Such compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of structure (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
摘要翻译: 结构(I)的化合物:包括立体异构体及其药学上可接受的盐,其中X,R 1,R 2,R 3,R 4,R 5,R 6和R 7如本文所定义。 这些化合物具有作为SHIP1调节剂的活性,因此可用于治疗将受益于SHIP1调节的各种疾病,障碍或病症中的任何一种。 还公开了包含结构(I)化合物与药学上可接受的载体或稀释剂组合的组合物,以及通过将这些化合物施用于有需要的动物的SHIP1调节方法。
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公开(公告)号:US20110136802A1
公开(公告)日:2011-06-09
申请号:US12960318
申请日:2010-12-03
申请人: Lloyd Mackenzie , Tom MacRury , Curtis Harwig , Jeremy Pettigrew , Noor Aini Bhatti , Sam Place , Paul Bird , Vladimir Khlebnikov , Rudong Shan
发明人: Lloyd Mackenzie , Tom MacRury , Curtis Harwig , Jeremy Pettigrew , Noor Aini Bhatti , Sam Place , Paul Bird , Vladimir Khlebnikov , Rudong Shan
IPC分类号: A61K31/5377 , C07D335/04 , A61K31/382 , C07D413/12 , C07D403/10 , A61K31/496 , C07D401/10 , A61K31/4535 , C07D311/78 , A61K31/352 , A61P11/00 , A61P1/00 , A61P19/02 , A61P1/04 , A61P11/06 , A61P25/28 , A61P27/02 , A61P17/06 , A61P35/00
CPC分类号: C07D335/04 , C07D311/78 , C07D409/06
摘要: Compounds of structure (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Such compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of structure (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
摘要翻译: 结构(I)的化合物:包括立体异构体及其药学上可接受的盐,其中X,R 1,R 2,R 3,R 4,R 5,R 6和R 7如本文所定义。 这些化合物具有作为SHIP1调节剂的活性,因此可用于治疗将受益于SHIP1调节的各种疾病,障碍或病症中的任何一种。 还公开了包含结构(I)化合物与药学上可接受的载体或稀释剂组合的组合物,以及通过将这些化合物施用于有需要的动物的SHIP1调节方法。
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