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    Triazaspiro compounds useful for treating or preventing pain
    2.
    发明授权
    Triazaspiro compounds useful for treating or preventing pain 有权
    可用于治疗或预防疼痛的三氮唑类化合物

    公开(公告)号：US07414062B2

    公开(公告)日：2008-08-19

    申请号：US11155263

    申请日：2005-06-16

    申请人： Zhengming Chen ,  Sam Victory

    发明人： Zhengming Chen ,  Sam Victory

    IPC分类号： A61K31/438 ,  C07D401/04

    CPC分类号： C07D471/10

    摘要： Triazaspiro Compounds, compositions comprising a Triazaspiro Compound, methods for treating or preventing pain in an animal comprising administering to an animal in need thereof an effective amount of a Triazaspiro Compound and methods for stimulating opioid-receptor function in a cell comprising contacting a cell capable of expressing an opioid receptor with an effective amount of a Triazaspiro Compound are disclosed.

    摘要翻译： 三唑类化合物，包含三氮唑类化合物的组合物，用于治疗或预防动物疼痛的方法，包括向有需要的动物施用有效量的三氮嘧啶化合物和刺激细胞中阿片受体功能的方法，包括使能够 公开了表达具有有效量的三氮唑螺化合物的阿片受体。

    Therapeutic agents useful for treating pain
    4.
    发明授权
    Therapeutic agents useful for treating pain 有权

    公开(公告)号：US08536177B2

    公开(公告)日：2013-09-17

    申请号：US13205323

    申请日：2011-08-08

    申请人： Qun Sun ,  Laykea Tafesse ,  Sam Victory

    发明人： Qun Sun ,  Laykea Tafesse ,  Sam Victory

    IPC分类号： A61K31/497 ,  A61K31/435 ,  C07D279/10 ,  C07D401/14

    CPC分类号： C07D417/12 ,  A61K31/495 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

    摘要： A compound of formula: wherein Ar1, A, R3, x, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a “Benzoazolylpiperazine Compound”), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound are disclosed.

    Therapeutic agents useful for treating pain
    5.
    发明授权
    Therapeutic agents useful for treating pain 有权
    用于治疗疼痛的治疗剂

    公开(公告)号：US08008300B2

    公开(公告)日：2011-08-30

    申请号：US12499480

    申请日：2009-07-08

    申请人： Qun Sun ,  Laykea Tafesse ,  Sam Victory

    发明人： Qun Sun ,  Laykea Tafesse ,  Sam Victory

    IPC分类号： A61K31/50 ,  A61K31/497 ,  C07D403/04 ,  C07D241/02

    CPC分类号： C07D417/12 ,  A61K31/495 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

    摘要： A compound of formula: wherein Ar1, A, R3, x, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a “Benzoazolylpiperazine Compound”), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound are disclosed.

    摘要翻译： 下式的化合物：其中Ar1，A，R3，x和m如本文所公开，Ar 2是苯并噻唑基，苯并恶唑基或苯并咪唑基或其药学上可接受的盐（“苯并恶唑基哌嗪化合物”），包含苯并恶唑基哌嗪化合物 以及用于治疗或预防疼痛，UI，溃疡，IBD，IBS，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷， 限制性脑功能，亨廷顿氏舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，其中包括向有需要的动物施用有效量的苯并恶唑基哌嗪化合物。

    Triazaspiro compounds useful for treating or preventing pain
    7.
    发明申请
    Triazaspiro compounds useful for treating or preventing pain 有权
    可用于治疗或预防疼痛的三氮唑类化合物

    公开(公告)号：US20050009854A1

    公开(公告)日：2005-01-13

    申请号：US10448627

    申请日：2003-05-29

    申请人： Zhengming Chen ,  Sam Victory

    发明人： Zhengming Chen ,  Sam Victory

    IPC分类号： C07D471/10 ,  A61K31/4747

    CPC分类号： C07D471/10

    摘要： Triazaspiro Compounds, compositions comprising a Triazaspiro Compound, methods for treating or preventing pain in an animal comprising administering to an animal in need thereof an effective amount of a Triazaspiro Compound and methods for stimulating opioid-receptor function in a cell comprising contacting a cell capable of expressing an opioid receptor with an effective amount of a Triazaspiro Compound are disclosed.

    摘要翻译： 三唑类化合物，包含三氮唑类化合物的组合物，用于治疗或预防动物疼痛的方法，包括向有需要的动物施用有效量的三氮嘧啶化合物和刺激细胞中阿片受体功能的方法，包括使能够 公开了表达具有有效量的三氮唑螺化合物的阿片受体。

    Therapeutic agents useful for treating pain
    8.
    发明授权
    Therapeutic agents useful for treating pain 有权

    公开(公告)号：US08604037B2

    公开(公告)日：2013-12-10

    申请号：US13212941

    申请日：2011-08-18

    申请人： Qun Sun ,  Laykea Tafesse ,  Sam Victory

    发明人： Qun Sun ,  Laykea Tafesse ,  Sam Victory

    IPC分类号： A61K31/501 ,  A61K31/497 ,  C07D409/04 ,  C07D409/12 ,  C07D417/04 ,  C07D417/12

    CPC分类号： C07D417/12 ,  A61K31/495 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

    摘要： A compound of formula: wherein Ar1, A, R3, x, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a “Benzoazolylpiperazine Compound”), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound are disclosed.