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1.发明申请Compositions and methods for short interfering nucleic acid inhibition of NAv1.8 有权NAv1.8短干扰核酸抑制的组成和方法公开(公告)号：US20060199779A1
公开(公告)日：2006-09-07
申请号：US11259588
申请日：2005-10-26
申请人： Sameer Goregaoker , John Hunter , Tony Priestley
发明人： Sameer Goregaoker , John Hunter , Tony Priestley
CPC分类号： C12N15/113 , C12N15/1138 , C12N2310/111 , C12N2310/14
摘要： The invention provides short interfering nucleic acids, either single-stranded or double-stranded, that cause RNAi-induced degradation of mRNA from the Nav1.8 sodium channel gene; to pharmaceutical compositions comprising such short interfering nucleic acids; recombinant vectors comprising such short interfering nucleic acids; a method for inhibiting translation of an mRNA; a method for inhibiting expression of a polypeptide; a method for blocking the membrane potential in a cell; a method for blocking the sodium current in a cell; and a method for inhibiting chronic pain.
摘要翻译： 本发明提供短干扰核酸，单链或双链，其引起RNAi诱导的来自Na + 1.8钠通道基因的mRNA的降解; 涉及包含这种短干扰核酸的药物组合物; 包含这种短干扰核酸的重组载体; 抑制mRNA翻译的方法; 抑制多肽表达的方法; 阻断细胞膜电位的方法; 阻止细胞中钠电流的方法; 和抑制慢性疼痛的方法。
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2.发明申请COMPOSITIONS AND METHODS FOR SHORT INTERFERING NUCLEIC ACID INHIBITION OF NAV1.8 有权短期干扰NAV1.8的核酸抑制剂的组合物和方法公开(公告)号：US20100305192A1
公开(公告)日：2010-12-02
申请号：US12789564
申请日：2010-05-28
CPC分类号： C12N15/113 , C12N15/1138 , C12N2310/111 , C12N2310/14
摘要： The invention provides short interfering nucleic acids, either single-stranded or double-stranded, that cause RNAi-induced degradation of mRNA from the Nav1.8 sodium channel gene; to pharmaceutical compositions comprising such short interfering nucleic acids; recombinant vectors comprising such short interfering nucleic acids; a method for inhibiting translation of an mRNA; a method for inhibiting expression of a polypeptide; a method for blocking the membrane potential in a cell; a method for blocking the sodium current in a cell; and a method for inhibiting chronic pain.
摘要翻译： 本发明提供短链干扰核酸，单链或双链，其导致RNAi诱导的来自Nav1.8钠通道基因的mRNA降解; 涉及包含这种短干扰核酸的药物组合物; 包含这种短干扰核酸的重组载体; 抑制mRNA翻译的方法; 抑制多肽表达的方法; 阻断细胞膜电位的方法; 阻止细胞中钠电流的方法; 和抑制慢性疼痛的方法。
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3.发明授权Compositions and methods for short interfering nucleic acid inhibition of Nav1.8 有权Nav1.8短干扰核酸抑制的组成和方法公开(公告)号：US07786291B2
公开(公告)日：2010-08-31
申请号：US11259588
申请日：2005-10-26
CPC分类号： C12N15/113 , C12N15/1138 , C12N2310/111 , C12N2310/14
摘要： The invention provides short interfering nucleic acids, either single-stranded or double-stranded, that cause RNAi-induced degradation of mRNA from the Nav1.8 sodium channel gene; to pharmaceutical compositions comprising such short interfering nucleic acids; recombinant vectors comprising such short interfering nucleic acids; a method for inhibiting translation of an mRNA; a method for inhibiting expression of a polypeptide; a method for blocking the membrane potential in a cell; a method for blocking the sodium current in a cell; and a method for inhibiting chronic pain.
摘要翻译： 本发明提供短链干扰核酸，单链或双链，其导致RNAi诱导的来自Nav1.8钠通道基因的mRNA降解; 涉及包含这种短干扰核酸的药物组合物; 包含这种短干扰核酸的重组载体; 抑制mRNA翻译的方法; 抑制多肽表达的方法; 阻断细胞膜电位的方法; 阻止细胞中钠电流的方法; 和抑制慢性疼痛的方法。
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4.发明申请COMPOSITIONS AND METHODS FOR SHORT INTERFERING NUCLEIC ACID INHIBITION OF Nav 1.8 审中-公开组合物和方法用于短暂干扰核酸的抑制作用公开(公告)号：US20140256787A1
公开(公告)日：2014-09-11
申请号：US14258391
申请日：2014-04-22
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N15/1138 , C12N2310/111 , C12N2310/14
摘要： The invention provides short interfering nucleic acids, either single-stranded or double-stranded, that cause RNAi-induced degradation of mRNA from the Na.sub.v1.8 sodium channel gene; to pharmaceutical compositions comprising such short interfering nucleic acids; recombinant vectors comprising such short interfering nucleic acids; a method for inhibiting translation of an mRNA; a method for inhibiting expression of a polypeptide; a method for blocking the membrane potential in a cell; a method for blocking the sodium current in a cell; and a method for inhibiting chronic pain.
摘要翻译： 本发明提供短链干扰核酸，单链或双链，其引起RNAi诱导的来自Na.sv1.8钠通道基因的mRNA的降解; 涉及包含这种短干扰核酸的药物组合物; 包含这种短干扰核酸的重组载体; 抑制mRNA翻译的方法; 抑制多肽表达的方法; 阻断细胞膜电位的方法; 阻止细胞中钠电流的方法; 和抑制慢性疼痛的方法。
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5.发明授权Compositions and methods for short interfering nucleic acid inhibition of Nav1.8 有权Nav1.8短干扰核酸抑制的组成和方法公开(公告)号：US08309703B2
公开(公告)日：2012-11-13
申请号：US12789564
申请日：2010-05-28
CPC分类号： C12N15/113 , C12N15/1138 , C12N2310/111 , C12N2310/14
摘要： The invention provides short interfering nucleic acids, either single-stranded or double-stranded, that cause RNAi-induced degradation of mRNA from the Nav1.8 sodium channel gene; to pharmaceutical compositions comprising such short interfering nucleic acids; recombinant vectors comprising such short interfering nucleic acids; a method for inhibiting translation of an mRNA; a method for inhibiting expression of a polypeptide; a method for blocking the membrane potential in a cell; a method for blocking the sodium current in a cell; and a method for inhibiting chronic pain.
摘要翻译： 本发明提供短链干扰核酸，单链或双链，其导致RNAi诱导的来自Nav1.8钠通道基因的mRNA降解; 涉及包含这种短干扰核酸的药物组合物; 包含这种短干扰核酸的重组载体; 抑制mRNA翻译的方法; 抑制多肽表达的方法; 阻断细胞膜电位的方法; 阻止细胞中钠电流的方法; 和抑制慢性疼痛的方法。
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