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公开(公告)号：US20080139535A1
公开(公告)日：2008-06-12
申请号：US12019356
申请日：2008-01-24
IPC分类号： A61K31/5513 , C07D417/02 , C07D243/14 , A61K31/445 , A61P35/00 , C07D401/02 , A61K31/497
CPC分类号： C07D277/56 , C07D277/42 , C07D417/04
摘要： Disclosed are compounds which inhibit histone deacetylase (HDAC) enzymatic activity. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC.
摘要翻译： 公开了抑制组蛋白脱乙酰酶（HDAC）酶活性的化合物。 还公开了包含这些化合物的药物组合物以及至少部分由HDAC介导的治疗条件，特别是增殖病症的方法。
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公开(公告)号：US07361743B2
公开(公告)日：2008-04-22
申请号：US11217836
申请日：2005-08-31
IPC分类号： C07H15/16
CPC分类号： C07H15/16
摘要： Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including Gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
摘要翻译： 公开了新的林可霉素衍生物。 这些林可霉素衍生物具有抗菌活性。 本发明的化合物可以表现出对细菌的有效活性，包括革兰氏阳性生物，并且可以是有用的抗微生物剂。 还公开了化合物的合成和使用方法。
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公开(公告)号：US07345043B2
公开(公告)日：2008-03-18
申请号：US11096550
申请日：2005-04-01
申请人： Sampath K. Anandan , Xiao-Yi Xiao , Dinesh V. Patel , John Ward
发明人： Sampath K. Anandan , Xiao-Yi Xiao , Dinesh V. Patel , John Ward
IPC分类号： A61K31/497 , A61K31/427 , A61K31/4535 , A61K31/454 , C07D417/04 , C07D277/28
CPC分类号： C07D277/56 , C07D277/42 , C07D417/04
摘要： Disclosed are compounds which inhibit histone deacetylase (HDAC) enzymatic activity. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC.
摘要翻译： 公开了抑制组蛋白脱乙酰酶（HDAC）酶活性的化合物。 还公开了包含这些化合物的药物组合物以及至少部分由HDAC介导的治疗条件，特别是增殖病症的方法。
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公开(公告)号：US07256177B2
公开(公告)日：2007-08-14
申请号：US10992564
申请日：2004-11-17
摘要： Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including Gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
摘要翻译： 公开了新的林可霉素衍生物。 这些林可霉素衍生物具有抗菌活性。 本发明的化合物可以表现出对细菌的有效活性，包括革兰氏阳性生物，并且可以是有用的抗微生物剂。 还公开了化合物的合成和使用方法。
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公开(公告)号：US07772245B2
公开(公告)日：2010-08-10
申请号：US11354594
申请日：2006-02-14
IPC分类号： A61K31/506 , C07D471/02
CPC分类号： C07D471/04 , C07D401/04 , C07D487/04 , C07D491/04 , C07D495/04
摘要： Disclosed are compounds of formula I that inhibit histone deacetylase (HDAC) enzymatic activity, pharmaceutical compositions comprising such compounds, as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC, wherein A, W, W1, W2, Ar2, and G are described herein.
摘要翻译： 公开了抑制组蛋白脱乙酰酶（HDAC）酶活性的式I化合物，包含这些化合物的药物组合物以及至少部分由HDAC介导的条件，特别是增殖性病症的方法，其中A，W，W1，W2 ，Ar2和G。
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公开(公告)号：US07164011B2
公开(公告)日：2007-01-16
申请号：US10642807
申请日：2003-08-15
IPC分类号： C07H15/26
摘要： Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
摘要翻译： 公开了新的林可霉素衍生物。 这些林可霉素衍生物具有抗菌活性。 由于本发明的化合物表现出对细菌（包括革兰氏阳性生物）的有效活性，因此它们是有用的抗微生物剂。 还公开了化合物的合成和使用方法。
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