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公开(公告)号:US20100311077A1
公开(公告)日:2010-12-09
申请号:US12725415
申请日:2010-03-16
申请人: Samuel Aparicio , John Dixon , Alan Hendrick , Jennifer M. Horwood , Dirk Zahn
发明人: Samuel Aparicio , John Dixon , Alan Hendrick , Jennifer M. Horwood , Dirk Zahn
IPC分类号: G01N33/53
CPC分类号: G01N33/556 , G01N2333/726 , G01N2500/00
摘要: We describe a method of identifying a molecule suitable for the treatment, prophylaxis or alleviation of a Gpr100 associated disease, in particular diabetes and obesity, the method comprising determining whether a candidate molecule is an agonist or antagonist of Gpr100 polypeptide, in which the Gpr100 polypeptide comprises the amino acid sequence shown in SEQ ID NO: 3 or SEQ ID NO: 5, or a sequence which is at least 90% identical thereto.
摘要翻译: 我们描述了鉴定适合于治疗,预防或减轻Gpr100相关疾病,特别是糖尿病和肥胖症的分子的方法,该方法包括确定候选分子是否是Gpr100多肽的激动剂或拮抗剂,其中Gpr100多肽 包含SEQ ID NO:3或SEQ ID NO:5所示的氨基酸序列,或与其至少90%相同的序列。
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公开(公告)号:US20080269118A1
公开(公告)日:2008-10-30
申请号:US11643408
申请日:2006-12-21
IPC分类号: A61K38/17 , G01N33/566 , C12Q1/02 , A61P3/10 , A61P3/04 , A01K67/027 , C12N5/06
CPC分类号: G01N33/556 , G01N2333/726 , G01N2500/00
摘要: We describe a method of identifying a molecule suitable for the treatment, prophylaxis or alleviation of a Gpr100 associated disease, in particular diabetes and obesity, the method comprising determining whether a candidate molecule is an agonist or antagonist of Gpr100 polypeptide, in which the Gpr100 polypeptide comprises the amino acid sequence shown in SEQ ID NO: 3 or SEQ ID NO: 5, or a sequence which is at least 90% identical thereto.
摘要翻译: 我们描述了鉴定适合于治疗,预防或减轻Gpr100相关疾病,特别是糖尿病和肥胖症的分子的方法,该方法包括确定候选分子是否是Gpr100多肽的激动剂或拮抗剂,其中Gpr100多肽 包含SEQ ID NO:3或SEQ ID NO:5所示的氨基酸序列,或与其至少90%相同的序列。
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公开(公告)号:US20100272647A1
公开(公告)日:2010-10-28
申请号:US12612267
申请日:2009-11-04
申请人: Samuel Aparicio , Mark Carlton , John Dixon , Sophie Messager , Andreas Russ , Rosemary Thresher
发明人: Samuel Aparicio , Mark Carlton , John Dixon , Sophie Messager , Andreas Russ , Rosemary Thresher
CPC分类号: C07K14/705
摘要: We disclose BACH G-protein coupled receptor (GPCR) polypeptides comprising the amino acid sequence shown in SEQ ID NO. 3 or SEQ ID NO: 5, and homologues, variants and derivatives thereof Nucleic acids capable of encoding BACH polypeptide are also disclosed, in particular, those comprising the nucleic acid sequences shown in SEQ ID No. 1, SEQ ID No.2 or SEQ ID NO: 4 or a mouse BACH genomic sequence (SEQ ID NO: 10).
摘要翻译: 我们公开了包含SEQ ID NO:1所示氨基酸序列的BACH G蛋白偶联受体(GPCR)多肽。 3或SEQ ID NO:5及其同源物,变体和衍生物还能够公开能够编码BACH多肽的核酸,特别是包含SEQ ID No.1,SEQ ID No.2或SEQ所示的核酸序列的核酸 SEQ ID NO:4或小鼠BACH基因组序列(SEQ ID NO:10)。
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公开(公告)号:US20050160486A1
公开(公告)日:2005-07-21
申请号:US10900930
申请日:2004-07-27
申请人: Samuel Aparicio , Mark Carlton , John Dixon , Sophie Messager , Andreas Russ , Rosemary Thresher
发明人: Samuel Aparicio , Mark Carlton , John Dixon , Sophie Messager , Andreas Russ , Rosemary Thresher
IPC分类号: C07K14/705 , A01K67/027 , A61K38/17 , A61K39/395 , A61K48/00
CPC分类号: C07K14/705
摘要: We disclose a method of treating or preventing a disease selected from the group consisting of: a bladder disease, a bladder disorder, benign prostatic hyperplasia, bladder outlet obstruction, incontinence, including overflow and urge incontinence, urinary urge, cystitis, including interstitial cystitis and overactive bladder.
摘要翻译: 我们公开了一种治疗或预防选自以下的疾病的方法:膀胱疾病,膀胱病,良性前列腺增生,膀胱出口阻塞,失禁,包括溢流和急迫性尿失禁,尿急,膀胱炎,包括间质性膀胱炎和 膀胱过度活动
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公开(公告)号:US20050064549A1
公开(公告)日:2005-03-24
申请号:US10826572
申请日:2004-04-16
申请人: Samuel Aparicio , Mark Carlton , Philip Mitchell
发明人: Samuel Aparicio , Mark Carlton , Philip Mitchell
IPC分类号: C07H21/04 , C07K14/705
CPC分类号: C07K14/705
摘要: We disclose Conrad G-protein coupled receptor (GPCR) polypeptides comprising the amino acid sequence shown in SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 9, SEQ ID NO: 11, SEQ ID NO: 14 or SEQ ID NO: 17 and homologues, variants and derivatives thereof. Nucleic acids capable of encoding Conrad polypeptide are also disclosed, in particular, those comprising the nucleic acid sequences shown in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 10, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 15, SEQ ID NO: 16 or SEQ ID NO: 18.
摘要翻译: 我们公开了包含SEQ ID NO:3,SEQ ID NO:5,SEQ ID NO:9,SEQ ID NO:11,SEQ ID NO:14或SEQ ID NO:14所示氨基酸序列的Conrad G-蛋白偶联受体(GPCR) 编号:17及其同系物,变体和衍生物。 还公开了能够编码Conrad多肽的核酸,特别是包含SEQ ID NO:1,SEQ ID NO:2,SEQ ID NO:4,SEQ ID NO:6,SEQ ID NO:6所示的核酸序列的核酸。 7,SEQ ID NO:8,SEQ ID NO:10,SEQ ID NO:12,SEQ ID NO:13,SEQ ID NO:15,SEQ ID NO:16或SEQ ID NO:18。
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公开(公告)号:US20100158807A1
公开(公告)日:2010-06-24
申请号:US12575034
申请日:2009-10-07
申请人: Samuel Aparicio , Mark Carlton , John Dixon , Sophie Messager , Andreas Russ , Rosemary Thresher
发明人: Samuel Aparicio , Mark Carlton , John Dixon , Sophie Messager , Andreas Russ , Rosemary Thresher
CPC分类号: C07K14/705
摘要: We disclose a method of treating or preventing a disease selected from the group consisting of: a bladder disease, a bladder disorder, benign prostatic hyperplasia, bladder outlet obstruction, incontinence, including overflow and urge incontinence, urinary urge, cystitis, including interstitial cystitis and overactive bladder.
摘要翻译: 我们公开了一种治疗或预防选自以下的疾病的方法:膀胱疾病,膀胱病,良性前列腺增生,膀胱出口阻塞,失禁,包括溢流和急迫性尿失禁,尿急,膀胱炎,包括间质性膀胱炎和 膀胱过度活动
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公开(公告)号:US20060015954A1
公开(公告)日:2006-01-19
申请号:US11114750
申请日:2005-04-25
申请人: Samuel Aparicio , William Colledge , John Dixon , Alan Hendrick , Sophie Messager , Rosemary Thresher , Dirk Zahn
发明人: Samuel Aparicio , William Colledge , John Dixon , Alan Hendrick , Sophie Messager , Rosemary Thresher , Dirk Zahn
IPC分类号: A01K67/027 , C12Q1/68
CPC分类号: C12N15/8509 , A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2227/10 , A01K2227/105 , A01K2267/01 , A01K2267/03 , A01K2267/0362 , A61K38/00 , A61K48/00 , C07K14/723 , G01N33/5023 , G01N2800/2821
摘要: The present invention relates to novel functions of a known receptor. In particular, the invention relates to the use of a galanin-like receptor and/or ligands thereof in the manipulation of the pituitary hormonal axis and reproductive systems.
摘要翻译: 本发明涉及已知受体的新功能。 特别地,本发明涉及甘露糖样受体和/或其配体在操纵垂体激素轴和生殖系统中的用途。
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公开(公告)号:US20050026825A1
公开(公告)日:2005-02-03
申请号:US10714161
申请日:2003-11-14
申请人: Mark Carlton , Samuel Aparicio , John Dixon , Rosemary Thresher , Dirk Zahn
发明人: Mark Carlton , Samuel Aparicio , John Dixon , Rosemary Thresher , Dirk Zahn
IPC分类号: A61K48/00 , C07K14/72 , C12N15/12 , A01K67/00 , A01K67/027 , C07H21/04 , C07K14/705
CPC分类号: C07K14/723 , A61K48/00
摘要: We disclose Mowgli G-protein coupled receptor (GPCR) polypeptides comprising the amino acid sequence shown in SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 6 or SEQ ID NO: 8, and homologues, variants and derivatives thereof. Nucleic acids capable of encoding Mowgli polypeptide are also disclosed, in particular, those comprising the nucleic acid sequences shown in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 7 or SEQ ID NO: 10.
摘要翻译: 我们公开了包含SEQ ID NO:3,SEQ ID NO:5,SEQ ID NO:6或SEQ ID NO:8所示氨基酸序列的Mowgli G蛋白偶联受体(GPCR)多肽及其同源物,变体和衍生物 。 还公开了能够编码Mowgli多肽的核酸,特别是包含SEQ ID NO:1,SEQ ID NO:2,SEQ ID NO:4,SEQ ID NO:7或SEQ ID NO: 10。
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