公开(公告)号：US20060052592A1

公开(公告)日：2006-03-09

申请号：US10518701

申请日：2003-06-20

申请人： Arnold Levinson ,  Sandra Calarota ,  David Weiner ,  Miguel Otero

发明人： Arnold Levinson ,  Sandra Calarota ,  David Weiner ,  Miguel Otero

IPC分类号： A61K48/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： A61K39/0005 ,  A61K39/00 ,  A61K39/08 ,  A61K2039/505 ,  A61K2039/53 ,  C07K16/00 ,  C07K2317/52 ,  C07K2318/10 ,  C07K2319/55

摘要： Nucleic acid molecules that encode a protein comprising at least one epitope of membrane IgE free of epitopes present on the serum IgE, including proteins that further comprise non-IgE T cell helper epitope are disclosed. Vaccines, vectors and host cells that comprise such nucleic acid molecules are disclosed. Isolated proteins, including haptenized proteins, comprising at least one epitope of membrane IgE free of epitopes present on the serum IgE, including proteins that further comprise non-IgE T cell helper epitope are disclosed. Vaccines that comprise and methods of making such proteins and antibodies that specifically bind to such proteins are disclosed. Killed or inactivated cells or particles, including haptenized killed or inactivated cells or particles, that comprise a protein comprising at least one epitope of membrane IgE free of epitopes present on the serum IgE, including proteins that further comprise non-IgE T cell helper epitope are disclosed. Vaccines that comprise such killed or inactivated cells or particles are disclosed. Methods of treating and preventing IgE mediated allergic disease or condition are disclosed.

摘要翻译： 公开了编码蛋白质的核酸分子，其包含不含存在于血清IgE上的表位的膜IgE的至少一个表位，包括进一步包含非IgE T细胞辅助表位的蛋白质。 公开了包含这种核酸分子的疫苗，载体和宿主细胞。 公开了分离的蛋白质，包括半抗体蛋白质，其包含至少一个不含存在于血清IgE上的表位的膜IgE表位，包括进一步包含非IgE T细胞辅助因子表位的蛋白质。 公开了包含制备这种蛋白质和特异性结合这些蛋白质的抗体的方法的疫苗。 杀伤或灭活的细胞或颗粒，包括半抗原的灭活或灭活的细胞或颗粒，其包含蛋白质的至少一个表位，所述蛋白质包含血清IgE上存在的表位的膜IgE的至少一个表位，包括进一步包含非IgE T细胞辅助表位的蛋白质 披露 公开了包含这种杀死或灭活的细胞或颗粒的疫苗。 公开了治疗和预防IgE介导的过敏性疾病或病症的方法。

公开(公告)号：US20140127244A1

公开(公告)日：2014-05-08

申请号：US14054621

申请日：2013-10-15

申请人： Arnold I. Levinson ,  Sandra Calarota ,  David B. Weiner ,  Miguel Otero

发明人： Arnold I. Levinson ,  Sandra Calarota ,  David B. Weiner ,  Miguel Otero

IPC分类号： A61K39/00 ,  A61K39/08

CPC分类号： A61K39/0005 ,  A61K39/00 ,  A61K39/08 ,  A61K2039/505 ,  A61K2039/53 ,  C07K16/00 ,  C07K2317/52 ,  C07K2318/10 ,  C07K2319/55

摘要： Nucleic acid molecules that encode a protein comprising at least one epitope of membrane IgE free of epitopes present on the serum IgE, including proteins that further comprise non-IgE T cell helper epitope are disclosed. Vaccines, vectors and host cells that comprise such nucleic acid molecules are disclosed. Isolated proteins, including haptenized proteins, comprising at least one epitope of membrane IgE free of epitopes present on the serum IgE, including proteins that further comprise non-IgE T cell helper epitope are disclosed. Vaccines that comprise and methods of making such proteins and antibodies that specifically bind to such proteins are disclosed. Vaccines that comprise killed or inactivated cells or particles are disclosed. Methods of treating and preventing IgE mediated allergic disease or condition are disclosed.

摘要翻译： 公开了编码蛋白质的核酸分子，其包含不含存在于血清IgE上的表位的膜IgE的至少一个表位，包括进一步包含非IgE T细胞辅助表位的蛋白质。 公开了包含这种核酸分子的疫苗，载体和宿主细胞。 公开了分离的蛋白质，包括半抗原蛋白，其包含至少一个不含存在于血清IgE上的表位的膜IgE表位，包括进一步包含非IgE T细胞辅助表位的蛋白质。 公开了包含制备这种蛋白质和特异性结合这些蛋白质的抗体的方法的疫苗。 公开了包含杀死或灭活的细胞或颗粒的疫苗。 公开了治疗和预防IgE介导的过敏性疾病或病症的方法。