公开(公告)号：US20140127244A1

公开(公告)日：2014-05-08

申请号：US14054621

申请日：2013-10-15

申请人： Arnold I. Levinson ,  Sandra Calarota ,  David B. Weiner ,  Miguel Otero

发明人： Arnold I. Levinson ,  Sandra Calarota ,  David B. Weiner ,  Miguel Otero

IPC分类号： A61K39/00 ,  A61K39/08

CPC分类号： A61K39/0005 ,  A61K39/00 ,  A61K39/08 ,  A61K2039/505 ,  A61K2039/53 ,  C07K16/00 ,  C07K2317/52 ,  C07K2318/10 ,  C07K2319/55

摘要： Nucleic acid molecules that encode a protein comprising at least one epitope of membrane IgE free of epitopes present on the serum IgE, including proteins that further comprise non-IgE T cell helper epitope are disclosed. Vaccines, vectors and host cells that comprise such nucleic acid molecules are disclosed. Isolated proteins, including haptenized proteins, comprising at least one epitope of membrane IgE free of epitopes present on the serum IgE, including proteins that further comprise non-IgE T cell helper epitope are disclosed. Vaccines that comprise and methods of making such proteins and antibodies that specifically bind to such proteins are disclosed. Vaccines that comprise killed or inactivated cells or particles are disclosed. Methods of treating and preventing IgE mediated allergic disease or condition are disclosed.

摘要翻译： 公开了编码蛋白质的核酸分子，其包含不含存在于血清IgE上的表位的膜IgE的至少一个表位，包括进一步包含非IgE T细胞辅助表位的蛋白质。 公开了包含这种核酸分子的疫苗，载体和宿主细胞。 公开了分离的蛋白质，包括半抗原蛋白，其包含至少一个不含存在于血清IgE上的表位的膜IgE表位，包括进一步包含非IgE T细胞辅助表位的蛋白质。 公开了包含制备这种蛋白质和特异性结合这些蛋白质的抗体的方法的疫苗。 公开了包含杀死或灭活的细胞或颗粒的疫苗。 公开了治疗和预防IgE介导的过敏性疾病或病症的方法。