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公开(公告)号:US20050037021A1
公开(公告)日:2005-02-17
申请号:US10935793
申请日:2004-09-07
申请人: Sandra Chang , Ann Hashimoto , Tani Nishimura
发明人: Sandra Chang , Ann Hashimoto , Tani Nishimura
IPC分类号: A61K39/015 , C07K14/445 , C12N15/82 , G01N33/53 , C07H21/04 , A61K39/002 , C12N5/06
CPC分类号: A61K39/015 , A61K2039/55566 , A61K2039/55577 , C07K14/445 , C12N15/8257 , Y02A50/412
摘要: Compositions and methods are provided for the induction of a protective immunize response in primates against a lethal challenge of Plasmodium.
摘要翻译: 提供组合物和方法用于在灵长类动物中诱导针对疟原虫致死性攻击的保护性免疫应答。
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公开(公告)号:US06420523B1
公开(公告)日:2002-07-16
申请号:US08195705
申请日:1994-02-14
申请人: Sandra Chang , George S. N. Hui , Philip J. Barr , Helen Gibson
发明人: Sandra Chang , George S. N. Hui , Philip J. Barr , Helen Gibson
IPC分类号: C07K100
CPC分类号: C07K14/445 , A61K39/00 , C12N2799/026 , Y02A50/412
摘要: The present invention provides compositions of matter comprising a polypeptide expressed from insect cells harboring a baculovirus vector the encodes the polypeptide, wherein the polypeptide comprises amino acid sequences derived from the p42 fragment of the Plasmodium falciparum gp 195 protein or derivatives thereof. Such compositions of matter find use for example for inducing the production of anti-p42 antibodies both in vivo and in vitro.
摘要翻译: 本发明提供了包含由携带编码多肽的杆状病毒载体的昆虫细胞表达的多肽的物质组合物,其中多肽包含衍生自恶性疟原虫gp1995蛋白质的p42片段的氨基酸序列或其衍生物。 这种物质组合物可用于例如在体内和体外诱导抗p42抗体的产生。
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公开(公告)号:US20050095255A1
公开(公告)日:2005-05-05
申请号:US10925385
申请日:2004-08-24
申请人: Sandra Chang , Kenton Kramer , William Gosnell , Tani Nishimura
发明人: Sandra Chang , Kenton Kramer , William Gosnell , Tani Nishimura
IPC分类号: A61K39/00 , A61K39/015 , C07K14/445 , C12N15/82 , C12Q1/68 , G01N33/53 , C07H21/04 , C12N9/02 , A61K39/002 , C12N15/74 , C12N5/06
CPC分类号: C12N15/8257 , A61K39/00 , A61K39/015 , A61K2039/55566 , A61K2039/55577 , C07K14/445 , C12N2799/026 , Y02A50/412
摘要: Compositions and methods are provided for the induction of a protective immunize response in primates against a lethal challenge of Plasmodium.
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公开(公告)号:US06214353B1
公开(公告)日:2001-04-10
申请号:US09083366
申请日:1998-05-21
IPC分类号: A61K39285
CPC分类号: C07K14/445 , A61K39/00 , C07K2319/00 , C12N2799/023 , Y02A50/412
摘要: What is described is a recombinant poxvirus, such as vaccinia virus, containing foreign DNA from Plasmodium Merozoite Surface Antigen 1. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine.
摘要翻译: 描述的是重组痘病毒,例如痘苗病毒,其含有来自裂殖酵母表面抗原的外源DNA 1.还描述了含有重组痘病毒的疫苗,用于在接种疫苗的宿主动物中诱导免疫应答。
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公开(公告)号:US5756101A
公开(公告)日:1998-05-26
申请号:US178476
申请日:1994-01-07
申请人: Enzo Paoletti , Charles de Taisne , Sandra Chang , George Hui , Wasim Siddiqui
发明人: Enzo Paoletti , Charles de Taisne , Sandra Chang , George Hui , Wasim Siddiqui
IPC分类号: A61K39/00 , A61P33/06 , C07K14/445 , C12N7/01 , A61K39/015 , A61K39/285 , C12P21/02
CPC分类号: C07K14/445 , A61K39/00 , C07K2319/00 , C12N2799/023
摘要: What is described is a recombinant poxvirus, such as vaccinia virus, containing foreign DNA from Plasmodium Merozoite Surface Antigen 1. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine.
摘要翻译: 描述的是重组痘病毒,例如痘苗病毒,其含有来自裂殖酵母表面抗原的外源DNA 1.还描述了含有重组痘病毒的疫苗,用于在接种疫苗的宿主动物中诱导免疫应答。
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公开(公告)号:US07285274B2
公开(公告)日:2007-10-23
申请号:US10925385
申请日:2004-08-24
申请人: Sandra Chang , Kenton Kramer , William Gosnell , Tani Nishimura
发明人: Sandra Chang , Kenton Kramer , William Gosnell , Tani Nishimura
CPC分类号: C12N15/8257 , A61K39/00 , A61K39/015 , A61K2039/55566 , A61K2039/55577 , C07K14/445 , C12N2799/026 , Y02A50/412
摘要: Compositions and methods are provided for the induction of a protective immunize response in primates against a lethal challenge of Plasmodium.
摘要翻译: 提供组合物和方法用于在灵长类动物中诱导针对疟原虫致死性攻击的保护性免疫应答。
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公开(公告)号:US07737262B2
公开(公告)日:2010-06-15
申请号:US10935793
申请日:2004-09-07
申请人: Sandra Chang , Ann Hashimoto , Tani Nishimura
发明人: Sandra Chang , Ann Hashimoto , Tani Nishimura
CPC分类号: A61K39/015 , A61K2039/55566 , A61K2039/55577 , C07K14/445 , C12N15/8257 , Y02A50/412
摘要: Compositions and methods are provided for the induction of a protective immunize response in primates against a lethal challenge of Plasmodium.
摘要翻译: 提供组合物和方法用于在灵长类动物中诱导针对疟原虫致死性攻击的保护性免疫应答。
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