Nanoparticle Based Immunological Stimulation
    1.
    发明申请
    Nanoparticle Based Immunological Stimulation 审中-公开
    基于纳米粒子的免疫刺激

    公开(公告)号:US20120189700A1

    公开(公告)日:2012-07-26

    申请号:US13350849

    申请日:2012-01-16

    摘要: A nanoparticle-based delivery system and methods for its use are disclosed. In one aspect, a nanoparticle-based delivery system comprising at least one molecule such as proteins, DNA/RNA or fragments thereof, carbohydrates, enzymes, chemicals, virus cells, bacteria, parts of a virus, parts of a bacteria, parts of a cell, part of a tissue, or a combination of one or more of these, which shall be referred to as immunogens, are chemically or physically combined with water soluble nanoparticles which, when administered to a living system, is capable of eliciting a desired immunological response. More particularly, the invention relates to nanoparticle-based delivery systems that are specifically engineered to enhance humoral or cellular immune response without the use of adjuvants.

    摘要翻译: 公开了一种基于纳米颗粒的递送系统及其使用方法。 一方面,包含至少一种分子如蛋白质,DNA / RNA或其片段,碳水化合物,酶,化学物质,病毒细胞,细菌,部分病毒,部分细菌的纳米粒子递送系统 细胞,组织的一部分或这些中的一种或多种的组合,其称为免疫原,与水溶性纳米颗粒化学或物理组合,当其施用于活体系时,能够引发所需的免疫学 响应。 更具体地,本发明涉及专门设计用于增强体液或细胞免疫应答而不使用佐剂的基于纳米颗粒的递送系统。