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公开(公告)号：US07338464B2
公开(公告)日：2008-03-04
申请号：US10626902
申请日：2003-07-25
CPC分类号： A61M5/14276 , A61M5/1452 , A61M5/16881 , A61M2005/14264 , A61M2005/14506 , A61M2205/33 , A61M2205/3372
摘要： The present invention relates to an implantable infusion pump having a refillable infusate reservoir in fluid communication with a delivery site via a flow path. This flow path includes a flow resistance. The infusion pump includes a sensing device(s), positioned relative to the flow path, to provide data regarding a flow rate along the flow path. The infusion pump effects a division of a total flow period into at least a plurality of unit dose periods, each unit dose period effecting delivery of a unit dose of infusate. The cumulative effect of delivering the total number of unit dose periods is the delivery of a desired dose over the total flow period. The present invention permits a reservoir pressure to vary over any portion of total flow period but effects a constant-pressure state over each unit dose cycle.
摘要翻译： 本发明涉及一种植入式输注泵，其具有经由流路与输送部位流体连通的可再填充输液管储存器。 该流路包括流动阻力。 输液泵包括相对于流动路径定位的感测装置，以提供关于沿着流动路径的流量的数据。 输注泵将总流动周期分成至少多个单位剂量周期，每个单位剂量周期影响输送单位剂量的输注液。 递送单位剂量周期总数的累积效应是在总流动周期内递送期望的剂量。 本发明允许储存器压力在总流动周期的任何部分上变化，但是在每个单位剂量周期上影响恒定压力状态。
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公开(公告)号：US20080020369A1
公开(公告)日：2008-01-24
申请号：US11552028
申请日：2006-10-23
CPC分类号： G01N33/5014 , G01N33/5058
摘要： A method for testing the cytotoxicity of an implant comprising: providing neuronal cells in-vitro; providing one or more compounds of the implantable medical device; adding the one or more compounds from the implantable medical device to the in-vitro neuronal cells; and determining a measure of the cytotoxicity of the one or more compounds based on an assessment of the neuronal cells.
摘要翻译： 一种用于测试植入物的细胞毒性的方法，包括：在体外提供神经元细胞; 提供一种或多种可植入医疗装置的化合物; 将一种或多种化合物从可植入医疗装置加入到体外神经元细胞中; 以及基于神经元细胞的评估确定所述一种或多种化合物的细胞毒性的量度。
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