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公开(公告)号：US4943560A
公开(公告)日：1990-07-24
申请号：US178139
申请日：1988-04-06
申请人： Bruce D. Wigness , Thomas D. Rohde
发明人： Bruce D. Wigness , Thomas D. Rohde
CPC分类号： A61K38/13 , A61K47/10 , A61K9/0019
摘要： The present invention provides a liquid infusate for the chronic vascular infusion of a hydrophobic biologically-active compound, such as cyclosporin, comprising a solution of a therapeutically-effective amount of the biologically-active compound in a mixture of about 10-80% glycerol and about 90-20% ethanol, by volume.
摘要翻译： 本发明提供了用于慢性血管输注疏水性生物活性化合物如环孢菌素的液体灌注液，其包含治疗有效量的生物活性化合物在约10-80％甘油和 约90-20％乙醇。
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公开(公告)号：US5290263A
公开(公告)日：1994-03-01
申请号：US919984
申请日：1992-07-27
申请人： Bruce D. Wigness , Frank D. Dorman
发明人： Bruce D. Wigness , Frank D. Dorman
CPC分类号： A61M25/0075 , A61M2025/0076
摘要： A vascular access system (20) utilizing a catheter (22) having at least one lumen with a bidirectional check valve assembly (24).
摘要翻译： 一种使用具有至少一个内腔的导管（22）的血管通路系统（20），其具有双向止回阀组件（24）。
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3.发明授权Metabolite sensor including a chemical concentration sensitive flow controller for a drug delivery system 失效代谢物传感器包括用于药物输送系统的化学浓度敏感流量控制器
公开(公告)号：US4705503A
公开(公告)日：1987-11-10
申请号：US825211
申请日：1986-02-03
申请人： Frank D. Dorman , Bruce D. Wigness
发明人： Frank D. Dorman , Bruce D. Wigness
CPC分类号： A61B5/14532 , A61M37/00 , A61M5/1723 , A61B5/1486 , A61M2025/0057
摘要： A system for the measurement of a metabolite in a physiological fluid is disclosed which comprises a catheter which includes an internal metabolite sensor downstream from a semipermeable region where dynamic equilibrium is attained between the external metabolite and a higher concentration of the same metabolite contained in an infusate which is flowed through the catheter. The changing metabolite concentration also can open and close a chemical valve to control the codelivery of a drug through the catheter.
摘要翻译： 公开了一种用于测量生理液体中的代谢物的系统，其包括导管，其包含在半透性区域下游的内部代谢物传感器，其中在外部代谢物与含有在灌注液中的较高浓度的相同代谢物之间达到动态平衡 其流过导管。 代谢物浓度的变化也可以打开和关闭一个化学阀门，以控制药物通过导管的输送。
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公开(公告)号：US4705501A
公开(公告)日：1987-11-10
申请号：US367683
申请日：1982-04-12
CPC分类号： A61M25/0032 , A61M25/0023 , A61M25/0075 , A61M39/0208 , A61M2025/0025 , A61M2039/0211 , A61M25/005
摘要： An implantable access system for infusion of liquids into a body or aspiration of liquid samples from the body. The system includes a septum/manifold (16) and catheter (10) connected thereto, both of specific design. The septum/manifold includes a pair of manifold chambers (24, 25) each closed with a self-sealing septum (20, 22) and each having a first access entry (19) and second access entry (26, 27) (35, 36). The catheter includes a pair of concentric inner and outer tubes (11, 12). The inner tube (11) is collapsible and closed at its distal end. The outer tube (12) closely engages the inner tube and defines a catheter lumen (28) therewith when the inner tube is collapsed by evacuation. The inner and outer tubes are joined together longitudinally over a small portion of the circumference of the inner tube.
摘要翻译： 用于将液体注入体内或从身体吸取液体样品的可植入进入系统。 该系统包括与其连接的隔膜/歧管（16）和导管（10），两者均具有特定设计。 隔膜/歧管包括一对歧管室（24,25），每个歧管腔室（24,25）用自密封隔膜（20,22）封闭，并且每个具有第一进入入口（19）和第二通道入口（26,27） 36）。 导管包括一对同心的内管和外管（11,12）。 内管（11）在其远端可折叠和封闭。 当内管通过排空而折叠时，外管（12）紧密地接合内管并且限定其内的导管内腔（28）。 内管和外管在内管的圆周的一小部分上纵向连接在一起。
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公开(公告)号：US4610658A
公开(公告)日：1986-09-09
申请号：US703758
申请日：1985-02-21
申请人： Henry Buchwald , Eugenio Guzman , Bruce D. Wigness
发明人： Henry Buchwald , Eugenio Guzman , Bruce D. Wigness
CPC分类号： A61M27/006 , A61M27/002 , A61M1/0066 , A61M2205/8206 , A61M39/0208
摘要： An implantable, anti-reflux, fluid displacement peritoneovenous shunt system. The system includes a double chambered multi-micro-orifice ascites collection device, a magnetically driven pump, and an anti-reflux, anti-backdiffusion, non-thrombogenic catheter tip, all connected by flexible tubing. The shunt is used to transfer fluid from the peritoneum to the cardiovascular system to prevent accumulation of fluid within the peritoneal cavity. The magnetically operated pump may be of either the reciprocating diaphragm or piston type or it may be a rotary driven bellows displacement pump.
摘要翻译： 一种可植入式，抗反流，流体置换的腹膜分流系统。 该系统包括双腔多微孔腹水收集装置，磁力驱动泵和抗回流，反向扩散，非血栓形成的导管尖端，全部通过柔性管连接。 分流器用于将流体从腹膜转移到心血管系统以防止液体在腹腔内积聚。 磁力操作泵可以是往复式隔膜或活塞型，也可以是旋转驱动的波纹管排量泵。
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公开(公告)号：US5203770A
公开(公告)日：1993-04-20
申请号：US862402
申请日：1992-04-02
申请人： Bruce D. Wigness , Frank D. Dorman
发明人： Bruce D. Wigness , Frank D. Dorman
CPC分类号： A61M25/0069 , A61M37/00
摘要： A method and apparatus for catheterization is provided. The method and apparatus are particularly suited for bone catheterization, i.e. access to an internal cavity of an animal, by means of a bone associated therewith. The preferred apparatus includes a tap arrangement and a cannula arrangement, provided in fluid flow communication with one another. The tap arrangement is constructed and arranged for anchoring within a bone, in fluid flow communication with the cavity. The cannula is preferably oriented for fluid flow access therewith, from a remote location. In preferred applications, the cannula arrangement is provided in communication with a medical access port and/or infusion pump arrangement. A preferred tool is described, for implanting the apparatus in a bone of the subject.
摘要翻译： 提供一种用于导管插入术的方法和装置。 所述方法和装置特别适用于通过与其相关联的骨进行骨导管插入，即进入动物的内腔。 优选的装置包括彼此流体连通地设置的抽头装置和插管装置。 龙头装置被构造和布置成用于锚固在骨骼内，与腔体流体连通。 套管优选地定位成用于从远处位置流体流动。 在优选的应用中，套管装置设置成与医疗进入口和/或输液泵装置连通。 描述了一种优选的工具，用于将装置植入受试者的骨骼中。
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公开(公告)号：US5073094A
公开(公告)日：1991-12-17
申请号：US121649
申请日：1987-11-17
申请人： Frank D. Dorman , Bruce D. Wigness
发明人： Frank D. Dorman , Bruce D. Wigness
CPC分类号： A61M5/14276 , F04B43/086 , F04B9/045 , A61M2202/0401 , A61M27/002
摘要： A zero net external displacement implantable pump for the transfer of accumulated body fluids, such as transfer of ascites fluid from the peritoneum to the vasculative system. The pump includes a pair of bellows type displacement chambers which are alternately compressed and expanded by action of a pivoted rocker member. The fluid to be transferred is drawn into the chambers on the expansion strokes and expelled on the compression strokes. The rocker member may be operated manually or power driven. Single action and double action pumps are disclosed.
摘要翻译： 用于转移积累的体液的零净外部位移植入式泵，例如将腹水从腹膜转移到血管系统。 该泵包括一对波纹管式位移室，其通过枢转的摇臂构件的作用交替地压缩和膨胀。 要传送的流体在膨胀冲程中被吸入室中并在压缩冲程上排出。 摇杆构件可以手动操作或动力驱动。 公开了单作用泵和双作用泵。
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公开(公告)号：US4846806A
公开(公告)日：1989-07-11
申请号：US105740
申请日：1987-10-06
申请人： Bruce D. Wigness , Frank D. Dorman
发明人： Bruce D. Wigness , Frank D. Dorman
IPC分类号： A61M39/02
CPC分类号： A61M39/0208 , A61M2039/0226
摘要： An implantable intravascular access system, including an implantable, catheter obturator controller manifold for use with an implantable intravascular catheter. The catheter includes a lumen, having an expanded state and a normal state, an obturator, and an obturator plenum having an inflated state and a contracted state. The lumen can be closed or opened by hydraulically actuating the expansion or contraction of the obturator plenum when the lumen is in its normal state. When the obturator plenum is expanded to its inflated state, the obturator substantially blocks the lumen such that substantially no fluid can pass through the lumen when the lumen is in its normal state. The manifold comprises a housing, a receiving mechanism for receiving the catheter, an actuating mechanism for hydraulically actuating the expansion or contraction of the plenum, and a first entry mechanism for entering the housing.
摘要翻译： 可植入的血管内存取系统，包括可植入的导管闭塞控制器歧管，用于与可植入的血管内导管一起使用。 导管包括具有膨胀状态和正常状态的管腔，闭孔器和具有膨胀状态和收缩状态的闭孔器室。 当管腔处于其正常状态时，腔可以通过液压致动闭孔器的膨胀或收缩来闭合或打开。 当闭孔器膨胀器膨胀到其膨胀状态时，闭孔器基本上阻塞内腔，使得当内腔处于其正常状态时基本上没有流体可以通过内腔。 歧管包括壳体，用于接收导管的接收机构，用于液压地致动增压室的膨胀或收缩的致动机构，以及用于进入壳体的第一进入机构。
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公开(公告)号：US4536179A
公开(公告)日：1985-08-20
申请号：US422758
申请日：1982-09-24
CPC分类号： B29C59/14 , A61L29/085 , A61M25/0045 , Y10S128/14 , Y10S128/21
摘要： Catheters for long term implantation having polymer surfaces in face-to-face contact which are provided with a thin film coating of a glow discharge plasma polymerized fluorocarbon to prevent adhesion of the contacting surfaces. The polymerized fluorocarbon film, between about 50 and 1000 Angstroms in thickness, is bonded to the substrate material giving a low surface energy without changing its bulk properties. The low surface energy will prevent adhesion of cured polymer surfaces in contact and act as a lubricant. The smooth pinhole-free films will control or prevent diffusion into or out of the bulk material. These biocompatible films provide an alternative use for polymers whose bulk properties are unacceptable but whose surface properties are desirable.
摘要翻译： 用于长期植入的导管，其具有面对面接触的聚合物表面，其设置有辉光放电等离子体聚合氟碳化物的薄膜涂层以防止接触表面的粘附。 在约50至1000埃厚度之间的聚合碳氟化合物薄膜粘合到基材上，赋予低表面能而不改变其本体特性。 低表面能将防止固化的聚合物表面的接触接触并用作润滑剂。 光滑的无针孔膜将控制或防止扩散进入或流出散装材料。 这些生物相容性膜提供了其体积特性是不可接受的但其表面性质是期望的聚合物的替代用途。
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公开(公告)号：US07338464B2
公开(公告)日：2008-03-04
申请号：US10626902
申请日：2003-07-25
CPC分类号： A61M5/14276 , A61M5/1452 , A61M5/16881 , A61M2005/14264 , A61M2005/14506 , A61M2205/33 , A61M2205/3372
摘要： The present invention relates to an implantable infusion pump having a refillable infusate reservoir in fluid communication with a delivery site via a flow path. This flow path includes a flow resistance. The infusion pump includes a sensing device(s), positioned relative to the flow path, to provide data regarding a flow rate along the flow path. The infusion pump effects a division of a total flow period into at least a plurality of unit dose periods, each unit dose period effecting delivery of a unit dose of infusate. The cumulative effect of delivering the total number of unit dose periods is the delivery of a desired dose over the total flow period. The present invention permits a reservoir pressure to vary over any portion of total flow period but effects a constant-pressure state over each unit dose cycle.
摘要翻译： 本发明涉及一种植入式输注泵，其具有经由流路与输送部位流体连通的可再填充输液管储存器。 该流路包括流动阻力。 输液泵包括相对于流动路径定位的感测装置，以提供关于沿着流动路径的流量的数据。 输注泵将总流动周期分成至少多个单位剂量周期，每个单位剂量周期影响输送单位剂量的输注液。 递送单位剂量周期总数的累积效应是在总流动周期内递送期望的剂量。 本发明允许储存器压力在总流动周期的任何部分上变化，但是在每个单位剂量周期上影响恒定压力状态。
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