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    Polyalkylene guanidine salts or polyalkylene biguanidine salts having a branched silane compound, method for preparing same and uses thereof
    3.
    发明授权
    Polyalkylene guanidine salts or polyalkylene biguanidine salts having a branched silane compound, method for preparing same and uses thereof 失效
    具有支链硅烷化合物的聚亚烷基胍盐或聚亚烷基双胍盐，其制备方法和用途

    公开(公告)号：US6031119A

    公开(公告)日：2000-02-29

    申请号：US889514

    申请日：1997-07-08

    申请人： Byung-Hyoung Lee ,  Woo-Sun Kim ,  Young-Jun Kim ,  Sang-Gu Bang ,  Kwang-Min Lim ,  Sang-Rak Choi ,  Keum-Chan Joo

    发明人： Byung-Hyoung Lee ,  Woo-Sun Kim ,  Young-Jun Kim ,  Sang-Gu Bang ,  Kwang-Min Lim ,  Sang-Rak Choi ,  Keum-Chan Joo

    IPC分类号： A01N55/00 ,  A01N55/10 ,  C08G73/00 ,  C08G73/02 ,  C08L79/00 ,  A61K31/155

    CPC分类号： C08G73/024 ,  A01N55/00 ,  C08G73/00 ,  C08G73/0253 ,  C08G73/0293

    摘要： Polyalkylene guanidine salts or polyalkylene biguanidine salts having a branched silane compound of formula I show excellent antimicrobial activity and can be applied to various materials including fibers, wood, paper, glass, resins and metals: ##STR1## wherein A is oxyethylene, oxypropylene, oxybutylene, oxystyrene, diphenylsulfone, diphenyl sulfide or alkylamide, which repeating number is 1 to 100,000, or straight or branched alkyl chain containing 1 to 20 carbon atoms;Y represents a blank, HCl, HBr, HI, HNO.sub.3, acetic acid, benzoic acid, dehydroacetic acid, propionic acid, gluconic acid, sorbic acid, phosphoric acid, fumaric acid, maleic acid, carbonic acid, sulfuric acid or para-toluene sulfonic acid;B is a straight or branched alkyl chain containing 0 to 20 carbon atoms;Z is an alkoxy group such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, pentoxy, hexoxy, octoxy or decoxy, chloride, bromide, iodide, acetate, sulfate, or paratoluenesulfonate;X is chloride, bromide, iodide, acetate, sulfate, paratoluenesulfonate, methoxy, ethoxy, propoxy, isopropoxy, butoxy, pentoxy, hexoxy, octoxy, or decoxy;x is 1 or 2;m is an integer of 0 or more; andn is an integer of 1 or more with a proviso that the ratio of m to n ranges from 0.01 to 100 in case of m+n=4 and when m is 0, n is an integer of 4 or more.

    摘要翻译： 具有式I的支化硅烷化合物的聚亚烷基胍盐或聚亚烷基双胍盐显示出优异的抗微生物活性，并且可以应用于包括纤维，木材，纸，玻璃，树脂和金属在内的各种材料：其中A是氧乙烯，氧丙烯，氧丁烯，氧苯乙烯， 重复数为1〜100,000的二苯砜，二苯硫醚或烷基酰胺，或含有1〜20个碳原子的直链或支链烷基链; Y代表空白，HCl，HBr，HI，HNO3，乙酸，苯甲酸，脱氢乙酸，丙酸，葡萄糖酸，山梨酸，磷酸，富马酸，马来酸，碳酸，硫酸或对甲苯磺酸 酸; B是含0至20个碳原子的直链或支链烷基链; Z是烷氧基如甲氧基，乙氧基，丙氧基，异丙氧基，丁氧基，戊氧基，己氧基，辛氧基或脱氧，氯化物，溴化物，碘化物，乙酸盐，硫酸盐或对甲苯磺酸盐; X是氯化物，溴化物，碘化物，乙酸盐，硫酸盐，对甲苯磺酸盐，甲氧基，乙氧基，丙氧基，异丙氧基，丁氧基，戊氧基，己氧基，辛氧基或脱氧; x为1或2; m为0以上的整数， n为1以上的整数，条件是在m + n = 4的情况下，m与n的比率为0.01〜100，当m为0时，n为4以上的整数。

    Pharmaceutical composition for prevention and treatment of drug or alcohol addiction or bipolar disorder using sodium phenylbutyrate
    6.
    发明授权
    Pharmaceutical composition for prevention and treatment of drug or alcohol addiction or bipolar disorder using sodium phenylbutyrate 有权
    使用苯丁酸钠预防和治疗药物或酒精成瘾或双相情感障碍的药物组合物

    公开(公告)号：US07968604B2

    公开(公告)日：2011-06-28

    申请号：US11992211

    申请日：2006-08-30

    申请人： Jeong-Woo Cho ,  Sang-Rak Choi ,  Sun-Gwan Hwang

    发明人： Jeong-Woo Cho ,  Sang-Rak Choi ,  Sun-Gwan Hwang

    IPC分类号： A61K31/12

    CPC分类号： A61K31/192 ,  Y10S514/809 ,  Y10S514/81 ,  Y10S514/812

    摘要： Provided is a pharmaceutical composition for prevention and treatment of drug or alcohol addiction or bipolar disorder, comprising sodium phenylbutyrate (PBA). The pharmaceutical composition for prevention and treatment of drug or alcohol addiction or bipolar disorder in accordance with the present invention provides effects capable of inhibiting increases in locomotor activity which is a behavioral indicator of drug or alcohol addiction or bipolar disorder, by controlling a level of a neurotransmitter via regulation of expression of a neurotransmitter transporter.

    摘要翻译： 提供了用于预防和治疗药物或酒精成瘾或双相性精神障碍的药物组合物，其包含苯丁酸钠（PBA）。 根据本发明的用于预防和治疗药物或酒精成瘾或双相性精神障碍的药物组合物提供了能够抑制作为药物或酒精成瘾或双相情感障碍的行为指标的运动活性增加的效果，通过控制 神经递质通过调节神经递质转运蛋白的表达。

    Pharmaceutical Composition for Prevention and Treatment of Drug or Alcohol Addiction or Bipolar Disorder Using Sodium Phenylbutyrate
    7.
    发明申请
    Pharmaceutical Composition for Prevention and Treatment of Drug or Alcohol Addiction or Bipolar Disorder Using Sodium Phenylbutyrate 有权
    使用苯丁酸钠预防和治疗药物或酒精成瘾或双相障碍的药物组合物

    公开(公告)号：US20090221714A1

    公开(公告)日：2009-09-03

    申请号：US11992211

    申请日：2006-08-30

    申请人： Jeong-Woo Cho ,  Sang-Rak Choi ,  Sun-Gwan Hwang

    发明人： Jeong-Woo Cho ,  Sang-Rak Choi ,  Sun-Gwan Hwang

    IPC分类号： A61K31/12 ,  A61P25/36

    CPC分类号： A61K31/192 ,  Y10S514/809 ,  Y10S514/81 ,  Y10S514/812

    摘要： Provided is a pharmaceutical composition for prevention and treatment of drug or alcohol addiction or bipolar disorder, comprising sodium phenylbutyrate (PBA). The pharmaceutical composition for prevention and treatment of drug or alcohol addiction or bipolar disorder in accordance with the present invention provides effects capable of inhibiting increases in locomotor activity which is a behavioral indicator of drug or alcohol addiction or bipolar disorder, by controlling a level of a neurotransmitter via regulation of expression of a neurotransmitter transporter.

    摘要翻译： 提供了用于预防和治疗药物或酒精成瘾或双相性精神障碍的药物组合物，其包含苯丁酸钠（PBA）。 根据本发明的用于预防和治疗药物或酒精成瘾或双相性精神障碍的药物组合物提供了能够抑制作为药物或酒精成瘾或双相情感障碍的行为指标的运动活性增加的效果，通过控制 神经递质通过调节神经递质转运蛋白的表达。