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公开(公告)号:US09669044B2
公开(公告)日:2017-06-06
申请号:US14281659
申请日:2014-05-19
IPC分类号: A61K31/7036 , A61K31/496 , A61K31/4196 , A61K31/506 , A61K31/415 , A61K31/365 , A01N43/16
CPC分类号: A61K31/7036 , A01N43/16 , A61K31/365 , A61K31/415 , A61K31/4196 , A61K31/496 , A61K31/506 , A61K2300/00 , A01N43/653 , A01N47/24
摘要: The present invention relates to novel fungicidal compound including an aminoglycoside analog having certain substituents at the 6 position of ring III that exhibit improved antifungal activity but possess minimal antibacterial properties in combination with fungicidal azoles. The aminoglycoside compounds are analogues of kanamycin A. Also provided are methods of synthesizing and methods of using the compounds of the present invention. The compounds of the present invention are useful in treating or preventing fungal disease.
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公开(公告)号:US20140256665A1
公开(公告)日:2014-09-11
申请号:US14281659
申请日:2014-05-19
IPC分类号: A61K31/7036 , A61K31/4174 , A61K31/506 , A61K31/415 , A61K31/496 , A61K31/4196
CPC分类号: A61K31/7036 , A01N43/16 , A61K31/365 , A61K31/415 , A61K31/4196 , A61K31/496 , A61K31/506 , A61K2300/00 , A01N43/653 , A01N47/24
摘要: The present invention relates to novel fungicidal compound including an aminoglycoside analog having certain substituents at the 6 position of ring III that exhibit improved antifungal activity but possess minimal antibacterial properties in combination with fungicidal azoles. The aminoglycoside compounds are analogues of kanamycin A. Also provided are methods of synthesizing and methods of using the compounds of the present invention. The compounds of the present invention are useful in treating or preventing fungal disease.
摘要翻译: 本发明涉及新型杀真菌化合物,其包括在环III的6位上具有某些取代基的氨基糖苷类似物,其具有改善的抗真菌活性,但与杀真菌唑组合具有最小的抗菌性能。 氨基糖苷类化合物是卡那霉素A的类似物。还提供了合成方法和使用本发明化合物的方法。 本发明的化合物可用于治疗或预防真菌性疾病。
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