公开(公告)号：US20060225980A1

公开(公告)日：2006-10-12

申请号：US11375716

申请日：2006-03-15

申请人： Stepan Simonian ,  Sarah Brennan

发明人： Stepan Simonian ,  Sarah Brennan

IPC分类号： F16F7/10

CPC分类号： B60G13/16 ,  F16F7/01 ,  F16F7/10 ,  F16F7/104

摘要： Apparatus, and a related method, for damping vibrations in a flexible structure by a combination of tuned mass damping and particle damping. Combining the two damping techniques in a single apparatus provides a desirable frequency response characteristic that provides damping over a wide frequency range and, because the apparatus is relatively insensitive to temperature changes, provides reliable damping in space structures exposed to extremes of temperature. Damping with the apparatus can be tuned and adjusted by selection of appropriate components for the tuned mass damping portion and, in the particle damper portion, by selection of a tuning beam length, the size and material of particles, and a particle container gap height.

摘要翻译： 用于通过调谐质量阻尼和粒子阻尼的组合来衰减柔性结构中的振动的装置和相关方法。 将两种阻尼技术组合在单个设备中提供了期望的频率响应特性，其在宽的频率范围内提供阻尼，并且由于该装置对温度变化相对不敏感，所以在暴露于极端温度的空间结构中提供可靠的阻尼。 可以通过选择调谐质量阻尼部分的适当部件和在粒子阻尼器部分中通过选择调谐光束长度，颗粒的尺寸和材料以及颗粒容器间隙高度来调节和调节阻尼。

公开(公告)号：US20100055705A1

公开(公告)日：2010-03-04

申请号：US12550601

申请日：2009-08-31

申请人： Gerald M. Wilson ,  Sarah Brennan ,  Nadim Alkharouf ,  Yuki Kuwano ,  Perry Blackshear ,  Myriam Gorospe

发明人： Gerald M. Wilson ,  Sarah Brennan ,  Nadim Alkharouf ,  Yuki Kuwano ,  Perry Blackshear ,  Myriam Gorospe

IPC分类号： C12Q1/68 ,  C12Q1/02

CPC分类号： G01N33/57484 ,  G01N2333/4703 ,  G01N2800/52 ,  G01N2800/56

摘要： The invention is drawn novel methods and compositions for the treatment of cancer, and for the diagnosis and prognosis of cancer in a subject. In particular aspects, the invention relates to the finding that the protein tristetraprolin (TTP) is decreased or repressed in a myriad and diversity of cancers. To this end, TTP represents a viable therapeutic option for the treatment of cancer. Additionally, TTP represents a clinically useful biomarker for the diagnosis and prognosis of cancer.

摘要翻译： 本发明描绘了用于治疗癌症的新颖方法和组合物，以及用于对象的癌症的诊断和预后。 在具体方面，本发明涉及蛋白质三螺环素（TTP）在多种多样的癌症中减少或抑制的发现。 为此，TTP代表了治疗癌症的可行治疗方案。 此外，TTP代表临床有用的癌症诊断和预后的生物标志物。

公开(公告)号：US20070131504A1

公开(公告)日：2007-06-14

申请号：US11304018

申请日：2005-12-14

申请人： Allen Bronowicki ,  Sarah Brennan ,  Stepan Simonian

发明人： Allen Bronowicki ,  Sarah Brennan ,  Stepan Simonian

IPC分类号： F16F7/10

CPC分类号： F16F15/035

摘要： A tuned mass damper for attenuating vibrations in a selected plane of a mechanical structure, by magnetically induced eddy current damping. A moving damper mass is coupled to a vibrating mass through one or more flexures that confine relative movement of the damper mass substantially to the selected plane. A magnet structure is rigidly attached to either the vibrating mass or the damper mass, and a conductor plate is attached to the other of these masses. Movement of the damper mass relative to the vibrating mass induces eddy currents in the conductor plate and thereby generates a damping force that attenuates vibration in the selected plane.

摘要翻译： 一种调谐质量阻尼器，用于通过磁感应涡流阻尼衰减机械结构的选定平面中的振动。 运动的阻尼器质量通过一个或多个挠曲件联接到振动块，其将阻尼块的相对运动基本上限制到所选择的平面。 磁体结构刚性地附接到振动块或阻尼块，并且导体板附接到这些块中的另一个。 阻尼器质量相对于振动质量块的运动在导体板中引起涡流，从而产生衰减所选平面中的振动的阻尼力。

公开(公告)号：US20070131830A1

公开(公告)日：2007-06-14

申请号：US11304974

申请日：2005-12-14

申请人： Sarah Brennan ,  Allen Bronowicki

发明人： Sarah Brennan ,  Allen Bronowicki

IPC分类号： A47G1/17

CPC分类号： F16F15/035

摘要： A passive magnetic damper suitable for use as a vibration isolator coupled between two masses, one of which is subject to vibration. The damper includes at least two pairs of rare earth permanent magnets configured to provide a narrow, generally planar gap, and backing plates positioned to complete a magnetic circuit passing through the magnets and the gap. A flat conductor plate is positioned to be freely movable in the gap. Any time-varying force on the conductor plate results in the generation of eddy currents in the plate, and these in turn generate a mechanical force on the plate, which resists the time-varying force and produces a damping effect. With careful selection of materials for the magnets, the backing plates and the conductive plate, the damper is effective over a wide temperature range that includes cryogenic temperatures, and is operable over a wide range of damping levels.

摘要翻译： 适用于耦合在两个质量块之间的隔振器的被动磁阻尼器，其中一个受到振动。 阻尼器包括至少两对被配置为提供窄的，大致平面的间隙的稀土永磁体，以及定位成完成通过磁体和间隙的磁路的背板。 扁平导体板被定位成能够在间隙中自由移动。 导体板上的任何时间变化的力导致板中产生涡流，并且这些反过来在板上产生机械力，其抵抗时变力并产生阻尼效应。 通过仔细选择用于磁体，背板和导电板的材料，阻尼器在包括低温温度的宽温度范围内有效，并且可在宽范围的阻尼水平下操作。