摘要:
This invention provides smooth muscle cell proliferation inhibitors of formula I having the structure wherein R1, R2, R3, R4, R5, R6, R7, and R8 are each, independently, acyl of 2–7 carbon atoms, haloacyl of 2–7 carbon atoms, nitroacyl of 2–7 carbon atoms, cyanoacyl of 2–7 carbon atoms, trifluoromethylacyl of 3–8 carbon atoms, benzoyl, or —SO3H; R9 is hydrogen, CN, NO2, halo, CF3, alkyl of 1–6 carbon atoms, or alkoxy of 1–6 carbon atoms; R10 is hydrogen, —NO2, —NHR11, —NHR13, —N(R13)2, —NCH3R13, —NHCO2alkyl, wherein the alkyl moiety contains 1–6 carbon atoms, alkylsulfonamide of 1 to 4 carbon atoms, Z is O or S; R11 is an α-amino acid in which the α carboxyl group forms an amide with the nitrogen of R10, wherein if said amino acid is glutamic acid or aspartic acid, the non-α carboxylic acid is an alkyl ester in which the alkyl moiety contains from 1–6 carbon atoms; R12 is hydrogen, CN, NO2, halo, CF3, alkyl of 1–6 carbon atoms, alkoxy of 1–6 carbon atoms, acyl of 2–7 carbon atoms, or benzoyl; R13 is hydrogen, acyl of 2–7 carbon atoms, haloacyl of 2–7 carbon atoms, nitroacyl of 2–7 carbon atoms, cyanoacyl of 2–7 carbon atoms, trifluoromethylacyl of 3–8 carbon atoms, or benzoyl; or a pharmaceutically acceptable salt thereof.
摘要翻译:本发明提供了具有以下结构的式I的平滑肌细胞增殖抑制剂,其中R 1,R 2,R 3,R 4, R 5,R 6,R 7,R 8和R 8各自独立地为氢, 2-7个碳原子的酰基,2-7个碳原子的卤代酰基,2-7个碳原子的硝基酰基,2-7个碳原子的氰基酰基,3-8个碳原子的三氟甲酰基,苯甲酰基或-SO 3 H; R 9是氢,CN,NO 2,卤素,CF 3,1-6个碳原子的烷基或1-6个碳原子的烷氧基 碳原子 R 10是氢,-NO 2,-NHR 11,-NHR 13,-N(R 6) 其中,R 1,R 2,R 3,R 3,R 3,R 3, 烷基部分含有1-6个碳原子,1至4个碳原子的烷基磺酰胺,Z是O或S; R 11是其中α羧基与R 10的氮形成酰胺的α-氨基酸,其中如果所述氨基酸是谷氨酸或天冬氨酸, 非α羧酸是烷基部分含有1-6个碳原子的烷基酯; R 12是氢,CN,NO 2,卤素,CF 3,1-6个碳原子的烷基,1-6个碳原子的烷氧基 原子,2-7个碳原子的酰基,或苯甲酰基; R 13是氢,2-7个碳原子的酰基,2-7个碳原子的卤代酰基,2-7个碳原子的硝基酰基,2-7个碳原子的氰基酰基,3-8个碳原子的三氟甲酰基 原子或苯甲酰基; 或其药学上可接受的盐。
摘要:
This invention provides compounds of Formula I having the structure wherein: B, C, D, and R1 are as defined hereinbefore in the specification, or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
摘要:
This invention provides smooth muscle cell proliferation inhibitors of formula I having the structure wherein R1, R2, R3, R4, R5, R6, R7, W, Y, and Z are defined herein; or a pharmaceutically acceptable salt thereof.
摘要:
This invention provides compounds of Formula I having the structure or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
摘要:
This invention provides compounds of Formula I having the structure wherein: B, C, D, and R1 are as defined hereinbefore in the specification, or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.