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1.2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia 失效
标题翻译: 用于治疗胰岛素抵抗和高血糖症的2,3,5-取代联苯公开(公告)号:US07008636B2
公开(公告)日:2006-03-07
申请号:US10843026
申请日:2004-05-11
申请人: John A. Butera , Craig E. Caufield , Russell F. Graceffa , Alexander Greenfield , Eric G. Gundersen , Lisa Marie Havran , Alan H. Katz , Joseph R. Lennox , Scott C. Mayer , Robert E. McDevitt
发明人: John A. Butera , Craig E. Caufield , Russell F. Graceffa , Alexander Greenfield , Eric G. Gundersen , Lisa Marie Havran , Alan H. Katz , Joseph R. Lennox , Scott C. Mayer , Robert E. McDevitt
IPC分类号: A61K31/343 , A61K31/19 , C07D307/78 , C07C53/134
CPC分类号: C07D213/40 , C07C17/16 , C07C45/68 , C07C45/71 , C07C47/575 , C07C205/35 , C07C205/37 , C07C309/77 , C07D209/08 , C07D233/54 , C07D263/58 , C07D307/58 , C07D307/80 , C07D307/81 , C07D317/54 , C07D333/74 , C07D413/12 , C07F9/4006 , C07C22/04
摘要: This invention provides compounds of Formula I having the structure or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
摘要翻译: 本发明提供了具有结构或其可药用盐的式I化合物,其可用于治疗与胰岛素抵抗或高血糖相关的代谢紊乱。
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2.2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia 失效
标题翻译: 用于治疗胰岛素抵抗和高血糖症的2,3,5-取代联苯公开(公告)号:US06451827B2
公开(公告)日:2002-09-17
申请号:US09771469
申请日:2001-01-26
申请人: John A. Butera , Craig E. Caufield , Russell F. Graceffa , Alexander Greenfield , Eric G. Gundersen , Lisa Marie Havran , Alan H. Katz , Joseph R. Lennox , Scott C. Mayer , Robert E. McDevitt
发明人: John A. Butera , Craig E. Caufield , Russell F. Graceffa , Alexander Greenfield , Eric G. Gundersen , Lisa Marie Havran , Alan H. Katz , Joseph R. Lennox , Scott C. Mayer , Robert E. McDevitt
IPC分类号: A61K3144
CPC分类号: C07D213/40 , C07C17/16 , C07C45/68 , C07C45/71 , C07C47/575 , C07C205/35 , C07C205/37 , C07C309/77 , C07D209/08 , C07D233/54 , C07D263/58 , C07D307/58 , C07D307/80 , C07D307/81 , C07D317/54 , C07D333/74 , C07D413/12 , C07F9/4006 , C07C22/04
摘要: This invention provides compounds of Formula I having the structure wherein: B, C, D, and R1 are as defined hereinbefore in the specification, or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
摘要翻译: 本发明提供具有结构的式I化合物,其中B,C,D和R 1如本说明书中所定义,或其药学上可接受的盐,其可用于治疗与胰岛素抵抗或高血糖相关的代谢紊乱。
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3.2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia 失效
标题翻译: 用于治疗胰岛素抵抗和高血糖症的2,3,5-取代联苯公开(公告)号:US06765021B2
公开(公告)日:2004-07-20
申请号:US10215438
申请日:2002-08-09
申请人: John A. Butera , Craig E. Caufield , Russell F. Graceffa , Alexander Greenfield , Eric G. Gundersen , Lisa Marie Havran , Alan H. Katz , Joseph R. Lennox , Scott C. Mayer , Robert E. McDevitt
发明人: John A. Butera , Craig E. Caufield , Russell F. Graceffa , Alexander Greenfield , Eric G. Gundersen , Lisa Marie Havran , Alan H. Katz , Joseph R. Lennox , Scott C. Mayer , Robert E. McDevitt
IPC分类号: A61K3117
CPC分类号: C07F9/4006 , C07B2200/07 , C07C17/16 , C07C45/68 , C07C45/71 , C07C47/575 , C07C205/35 , C07C205/37 , C07C225/20 , C07C233/43 , C07C235/46 , C07C235/48 , C07C235/52 , C07C237/30 , C07C255/54 , C07C271/12 , C07C271/16 , C07C271/28 , C07C271/30 , C07C309/77 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D209/08 , C07D213/40 , C07D233/54 , C07D263/58 , C07D295/088 , C07D295/13 , C07D307/58 , C07D307/80 , C07D307/81 , C07D317/54 , C07D333/74 , C07D413/12 , C07C22/04
摘要: This invention provides compounds of formula I having the structure wherein: B, D, C, and R1 as defined herein.
摘要翻译: 本发明提供具有本文定义的B,D,C和R 1结构的式I化合物。
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4.2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia 失效
标题翻译: 用于治疗胰岛素抵抗和高血糖症的2,3,5-取代联苯公开(公告)号:US06214877B1
公开(公告)日:2001-04-10
申请号:US09307850
申请日:1999-05-10
申请人: John A. Butera , Craig E. Caufield , Russell F. Graceffa , Alexander Greenfield , Eric G. Gundersen , Lisa Marie Havran , Alan H. Katz , Joseph R. Lennox , Scott C. Mayer , Robert E. McDevitt
发明人: John A. Butera , Craig E. Caufield , Russell F. Graceffa , Alexander Greenfield , Eric G. Gundersen , Lisa Marie Havran , Alan H. Katz , Joseph R. Lennox , Scott C. Mayer , Robert E. McDevitt
IPC分类号: A61K31166
CPC分类号: C07F9/4006 , C07B2200/07 , C07C17/16 , C07C45/68 , C07C45/71 , C07C47/575 , C07C205/35 , C07C205/37 , C07C225/20 , C07C233/43 , C07C235/46 , C07C235/48 , C07C235/52 , C07C237/30 , C07C255/54 , C07C271/12 , C07C271/16 , C07C271/28 , C07C271/30 , C07C309/77 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D209/08 , C07D213/40 , C07D233/54 , C07D263/58 , C07D295/088 , C07D295/13 , C07D307/58 , C07D307/80 , C07D307/81 , C07D317/54 , C07D333/74 , C07D413/12 , C07C22/04
摘要: This invention provides compounds of Formula I having the structure wherein: B, C, D, and R1 are as defined hereinbefore in the specification, or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
摘要翻译: 本发明提供具有结构的式I化合物,其中B,C,D和R 1如本说明书中所定义,或其药学上可接受的盐,其可用于治疗与胰岛素抵抗或高血糖相关的代谢紊乱。
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公开(公告)号:US20080293790A1
公开(公告)日:2008-11-27
申请号:US12180984
申请日:2008-07-28
申请人: Lisa Marie Havran , John Anthony Butera , Hassan Mahmoud Elokdah , Douglas John Jenkins , Eric Gould Gundersen
发明人: Lisa Marie Havran , John Anthony Butera , Hassan Mahmoud Elokdah , Douglas John Jenkins , Eric Gould Gundersen
IPC分类号: A61K31/41 , A61K31/195 , C07D257/04 , A61P25/28 , A61P9/10 , C07C251/24
CPC分类号: C07D257/04 , A61K31/195 , A61K31/343 , A61K31/40 , A61K31/445 , C07C251/54
摘要: The present invention relates to substituted aryl oximes and methods of using them.
摘要翻译: 本发明涉及取代的芳基肟及其使用方法。
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公开(公告)号:US07256198B2
公开(公告)日:2007-08-14
申请号:US11061144
申请日:2005-02-18
申请人: Paul Jeffrey Dollings , Arlene Joan Dietrich , Lisa Marie Havran , Chae-Koo Dan Chong , Donna Mary Huryn , Albert Jean Robichaud , Boyd Lynn Harrison , Wayne Everett Childers , Alexander A. Greenfield , James Jacob Bicksler , Vasilios Marathias
发明人: Paul Jeffrey Dollings , Arlene Joan Dietrich , Lisa Marie Havran , Chae-Koo Dan Chong , Donna Mary Huryn , Albert Jean Robichaud , Boyd Lynn Harrison , Wayne Everett Childers , Alexander A. Greenfield , James Jacob Bicksler , Vasilios Marathias
IPC分类号: A01N43/54 , A61K31/505 , C07D239/00 , C07D239/70 , C07D471/00 , C07D487/00
CPC分类号: C07D487/04 , C07D487/10
摘要: Novel pyrimidoindolone compounds are disclosed. Methods of using the pyrimidoindolone compounds and compositions containing the compounds in the treatment and/or prevention of disease and other conditions related to inflammation, neurodegeneration, osteoarthritis and apoptosis are also disclosed.
摘要翻译: 公开了新的嘧啶吲哚酮化合物。 还公开了使用嘧啶吲哚酮酮化合物和含有该化合物的组合物在治疗和/或预防与炎症,神经变性,骨关节炎和细胞凋亡相关的疾病和其它病状的方法。
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7.Piperazine-piperidine antagonists and agonists of the 5-HT1A receptor 失效
标题翻译: 哌嗪 - 哌啶拮抗剂和5-HT1A受体的激动剂公开(公告)号:US07671056B2
公开(公告)日:2010-03-02
申请号:US11450942
申请日:2006-06-09
申请人: Magda Asselin , George Theodore Grosu , Annmarie Louise Sabb , Wayne Everett Childers , Lisa Marie Havran , Zhongqi Shen , James Jacob Bicksler , Dan Chaekoo Chong
发明人: Magda Asselin , George Theodore Grosu , Annmarie Louise Sabb , Wayne Everett Childers , Lisa Marie Havran , Zhongqi Shen , James Jacob Bicksler , Dan Chaekoo Chong
IPC分类号: A61K31/496 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
CPC分类号: C07D403/14 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要: The present invention relates to novel piperazine-piperidine compounds. The compounds are useful as 5-HT1A binding agents, particularly as 5-HT1A receptor antagonists and agonists. These compounds are useful in treating central nervous system disorders, such as cognition disorders, anxiety disorders, depression and sexual dysfunction. The invention relates to compounds and pharmaceutically acceptable salts of formula (I′): wherein R1-R16, Ra, Rb, and n are set forth in the specification. The invention also relates to pharmaceutical compositions comprising compounds and pharmaceutically acceptable salts of formula (I′).
摘要翻译: 本发明涉及新的哌嗪 - 哌啶化合物。 该化合物可用作5-HT1A结合剂,特别是作为5-HT 1A受体拮抗剂和激动剂。 这些化合物可用于治疗中枢神经系统疾病,如认知障碍,焦虑障碍,抑郁症和性功能障碍。 本发明涉及式(I')的化合物和药学上可接受的盐:其中R1-R16,Ra,Rb和n在说明书中阐述。 本发明还涉及包含式(I')的化合物和药学上可接受的盐的药物组合物。
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公开(公告)号:US07420083B2
公开(公告)日:2008-09-02
申请号:US10948611
申请日:2004-09-23
申请人: Lisa Marie Havran , John Anthony Butera , Hassan Mahmoud Elokdah , Douglas John Jenkins , Eric Gould Gundersen
发明人: Lisa Marie Havran , John Anthony Butera , Hassan Mahmoud Elokdah , Douglas John Jenkins , Eric Gould Gundersen
CPC分类号: C07D257/04 , A61K31/195 , A61K31/343 , A61K31/40 , A61K31/445 , C07C251/54
摘要: The present invention relates to substituted aryl oximes and methods of using them.
摘要翻译: 本发明涉及取代的芳基肟及其使用方法。
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公开(公告)号:US07342039B2
公开(公告)日:2008-03-11
申请号:US10947846
申请日:2004-09-23
申请人: Lisa Marie Havran , John Anthony Butera , Hassan Mahmoud Elokdah , Douglas John Jenkins , Eric Gould Gundersen
发明人: Lisa Marie Havran , John Anthony Butera , Hassan Mahmoud Elokdah , Douglas John Jenkins , Eric Gould Gundersen
IPC分类号: A61K31/404 , C07D209/04
CPC分类号: C07D209/14
摘要: The present invention relates to substituted indole oximes and methods of using them.
摘要翻译: 本发明涉及取代的吲哚肟及其使用方法。
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