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公开(公告)号：US20100160423A1
公开(公告)日：2010-06-24
申请号：US12643574
申请日：2009-12-21
IPC分类号： A61K31/381 , A61K31/341 , C07D333/36 , C07D307/33 , A61P31/04 , A01N43/10 , A01N43/08 , A01P1/00
CPC分类号： A61K31/365 , A01N43/08 , A01N43/10 , A01N43/16 , A01N43/18 , A61K31/341 , A61K31/381 , C07D307/33 , C07D333/36
摘要： A novel small molecule antagonizes two types of acyl homoserine lactone receptors: membrane-bound and cytoplasmic. A focused library of analogs and derivatives of the original antagonist was synthesized. Analog and derivative molecules harbor a range of activities. The novel small molecule and most potent antagonist protects the eukaryote Caenorhabditis elegans from quorum-sensing-mediated killing by the bacterial pathogen Chromobacterium violaceum. The saving of C. elegans demonstrates the use of these molecules as small molecule antimicrobials.
摘要翻译： 一种新的小分子拮抗两种类型的酰基高丝氨酸内酯受体：膜结合和细胞质。 合成了原始拮抗剂类似物和衍生物的重点文库。 模拟和衍生分子具有一系列活动。 新型小分子和最有效的拮抗剂通过细菌病原体Chromobacterium violaceum从群体感应介导的杀伤中保护真核生物线虫。 秀丽隐杆线虫的保存证明了这些分子作为小分子抗菌药物的用途。
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公开(公告)号：US20090005328A1
公开(公告)日：2009-01-01
申请号：US12029333
申请日：2008-02-11
申请人： Eric M. Verdin , Brian J. North , Scott M. Ulrich
发明人： Eric M. Verdin , Brian J. North , Scott M. Ulrich
IPC分类号： A61K31/7056 , A61P35/00
CPC分类号： C12Q1/34 , C12Q1/32 , G01N2333/98 , G01N2500/02
摘要： The present invention provides methods for identifying agents that modulate a level or an activity of tubulin deacetylase polypeptide, as well as agents identified by the methods. The invention further provides methods of modulating tubulin deacetylase activity in a cell. The invention further provides methods of modulating cellular proliferation by modulating the activity of tubulin deacetylase.
摘要翻译： 本发明提供了鉴定调节微管蛋白脱乙酰酶多肽的水平或活性的试剂以及通过该方法鉴定的试剂的方法。 本发明还提供调节细胞中微管蛋白脱乙酰酶活性的方法。 本发明还提供了通过调节微管蛋白脱乙酰酶的活性来调节细胞增殖的方法。
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公开(公告)号：US08772331B2
公开(公告)日：2014-07-08
申请号：US13550961
申请日：2012-07-17
IPC分类号： A61K31/381 , C07D333/32
CPC分类号： A61K31/365 , A01N43/08 , A01N43/10 , A01N43/16 , A01N43/18 , A61K31/341 , A61K31/381 , C07D307/33 , C07D333/36
摘要： A novel small molecule antagonizes two types of acyl homoserine lactone receptors: membrane-bound and cytoplasmic. A focused library of analogs and derivatives of the original antagonist was synthesized. Analog and derivative molecules harbor a range of activities. The novel small molecule and most potent antagonist protects the eukaryote Caenorhabditis elegans from quorum-sensing-mediated killing by the bacterial pathogen Chromobacterium violaceum. The saving of C. elegans demonstrates the use of these molecules as small molecule antimicrobials.
摘要翻译： 一种新的小分子拮抗两种类型的酰基高丝氨酸内酯受体：膜结合和细胞质。 合成了原始拮抗剂类似物和衍生物的重点文库。 模拟和衍生分子具有一系列活动。 新型小分子和最有效的拮抗剂通过细菌病原体Chromobacterium violaceum从群体感应介导的杀伤中保护真核生物线虫。 秀丽隐杆线虫的保存证明了这些分子作为小分子抗菌药物的用途。
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公开(公告)号：US07884081B2
公开(公告)日：2011-02-08
申请号：US12029333
申请日：2008-02-11
申请人： Eric M. Verdin , Brian J. North , Scott M. Ulrich
发明人： Eric M. Verdin , Brian J. North , Scott M. Ulrich
CPC分类号： C12Q1/34 , C12Q1/32 , G01N2333/98 , G01N2500/02
摘要： The present invention provides methods for identifying agents that modulate a level or an activity of tubulin deacetylase polypeptide, as well as agents identified by the methods. The invention further provides methods of modulating tubulin deacetylase activity in a cell. The invention further provides methods of modulating cellular proliferation by modulating the activity of tubulin deacetylase.
摘要翻译： 本发明提供了鉴定调节微管蛋白脱乙酰酶多肽的水平或活性的试剂以及通过该方法鉴定的试剂的方法。 本发明还提供调节细胞中微管蛋白脱乙酰酶活性的方法。 本发明还提供了通过调节微管蛋白脱乙酰酶的活性来调节细胞增殖的方法。
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公开(公告)号：US07351542B2
公开(公告)日：2008-04-01
申请号：US10441854
申请日：2003-05-19
申请人： Eric M. Verdin , Brian J. North , Scott M. Ulrich
发明人： Eric M. Verdin , Brian J. North , Scott M. Ulrich
CPC分类号： C12Q1/34 , C12Q1/32 , G01N2333/98 , G01N2500/02
摘要： The present invention provides methods for identifying agents that modulate a level or an activity of tubulin deacetylase polypeptide, as well as agents identified by the methods. The invention further provides methods of modulating tubulin deacetylase activity in a cell. The invention further provides methods of modulating cellular proliferation by modulating the activity of tubulin deacetylase.
摘要翻译： 本发明提供了鉴定调节微管蛋白脱乙酰酶多肽的水平或活性的试剂以及通过该方法鉴定的试剂的方法。 本发明还提供调节细胞中微管蛋白脱乙酰酶活性的方法。 本发明还提供了通过调节微管蛋白脱乙酰酶的活性来调节细胞增殖的方法。
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公开(公告)号：US20140275232A1
公开(公告)日：2014-09-18
申请号：US14288984
申请日：2014-05-28
CPC分类号： A61K31/365 , A01N43/08 , A01N43/10 , A01N43/16 , A01N43/18 , A61K31/341 , A61K31/381 , C07D307/33 , C07D333/36
摘要： A novel small molecule antagonizes two types of acyl homoserine lactone receptors: membrane-bound and cytoplasmic. A focused library of analogs and derivatives of the original antagonist was synthesized. Analog and derivative molecules harbor a range of activities. The novel small molecule and most potent antagonist protects the eukaryote Caenorhabditis elegans from quorum-sensing-mediated killing by the bacterial pathogen Chromobacterium violaceum. The saving of C. elegans demonstrates the use of these molecules as small molecule antimicrobials.
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公开(公告)号：US20140024707A1
公开(公告)日：2014-01-23
申请号：US13550961
申请日：2012-07-17
IPC分类号： A01N43/08 , A61K31/365
CPC分类号： A61K31/365 , A01N43/08 , A01N43/10 , A01N43/16 , A01N43/18 , A61K31/341 , A61K31/381 , C07D307/33 , C07D333/36
摘要： A novel small molecule antagonizes two types of acyl homoserine lactone receptors: membrane-bound and cytoplasmic. A focused library of analogs and derivatives of the original antagonist was synthesized. Analog and derivative molecules harbor a range of activities. The novel small molecule and most potent antagonist protects the eukaryote Caenorhabditis elegans from quorum-sensing-mediated killing by the bacterial pathogen Chromobacterium violaceum. The saving of C. elegans demonstrates the use of these molecules as small molecule antimicrobials.
摘要翻译： 一种新的小分子拮抗两种类型的酰基高丝氨酸内酯受体：膜结合和细胞质。 合成了原始拮抗剂类似物和衍生物的重点文库。 模拟和衍生分子具有一系列活动。 新型小分子和最有效的拮抗剂通过细菌病原体Chromobacterium violaceum从群体感应介导的杀伤中保护真核生物线虫。 秀丽隐杆线虫的保存证明了这些分子作为小分子抗菌药物的用途。
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公开(公告)号：US08247443B2
公开(公告)日：2012-08-21
申请号：US12643574
申请日：2009-12-21
IPC分类号： A61K31/381 , C07D333/32
CPC分类号： A61K31/365 , A01N43/08 , A01N43/10 , A01N43/16 , A01N43/18 , A61K31/341 , A61K31/381 , C07D307/33 , C07D333/36
摘要： A novel small molecule antagonizes two types of acyl homoserine lactone receptors: membrane-bound and cytoplasmic. A focused library of analogs and derivatives of the original antagonist was synthesized. Analog and derivative molecules harbor a range of activities. The novel small molecule and most potent antagonist protects the eukaryote Caenorhabditis elegans from quorum-sensing-mediated killing by the bacterial pathogen Chromobacterium violaceum. The saving of C. elegans demonstrates the use of these molecules as small molecule antimicrobials.
摘要翻译： 一种新的小分子拮抗两种类型的酰基高丝氨酸内酯受体：膜结合和细胞质。 合成了原始拮抗剂类似物和衍生物的重点文库。 模拟和衍生分子具有一系列活动。 新型小分子和最有效的拮抗剂通过细菌病原体Chromobacterium violaceum从群体感应介导的杀伤中保护真核生物线虫。 秀丽隐杆线虫的保存证明了这些分子作为小分子抗菌药物的用途。
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