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1.发明授权Method for detecting chemical interactions between naturally occurring biological analyte molecules that are non-identical binding partners 有权用于检测天然存在的非相同结合配偶体的生物分析物分子之间化学相互作用的方法公开(公告)号：US06436647B1
公开(公告)日：2002-08-20
申请号：US09812706
申请日：2001-03-19
IPC分类号： C12Q168
CPC分类号： G01N33/54373 , C12Q1/6816 , Y10S977/80 , Y10S977/827 , Y10S977/835 , Y10S977/924 , Y10S977/957 , Y10S977/958 , C12Q2565/60
摘要： A method of using micromechanical devices as sensors for detecting chemical interactions between naturally occurring bio-polymers which are non-identical binding partners is provided. The method is useful whether the reactions occur through electrostatic forces or other forces. Induced stress, heat, or change in mass is detected where a binding partner is placed on a cantilever for possible reaction with an analyte molecules (i.e., a non-identical binding partner). The method is particularly useful in determining DNA hybridization but may be useful in detecting interaction in any chemical assay.
摘要翻译： 提供了使用微机械装置作为用于检测天然存在的生物聚合物之间的化学相互作用的传感器的方法，所述生物聚合物是不相同的结合配偶体。 无论反应是通过静电力还是其他力发生，该方法都是有用的。 检测到结合配偶体放置在悬臂上可能与分析物分子（即不相同的结合配偶体）反应的诱导的应激，热量或质量变化。 该方法特别可用于确定DNA杂交，但可用于检测任何化学测定中的相互作用。
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2.发明授权Method for detecting chemical interactions between naturally occurring bio-polymers which are non-identical binding partners 失效用于检测作为不相同结合配偶体的天然存在的生物聚合物之间的化学相互作用的方法公开(公告)号：US06203983B1
公开(公告)日：2001-03-20
申请号：US09097675
申请日：1998-06-16
IPC分类号： C12Q168
CPC分类号： G01N33/54373 , C12Q1/6816 , Y10S977/80 , Y10S977/827 , Y10S977/835 , Y10S977/924 , Y10S977/957 , Y10S977/958 , C12Q2565/60
摘要： A method of using micromechanical devices as sensors for detecting chemical interactions between naturally occurring bio-polymers which are non-identical binding partners is provided. The method is useful whether the reactions occur through electrostatic forces or other forces. Induced stress, heat, or change in mass is detected where a binding partner is placed on a cantilever for possible reaction with an analyte molecules (i.e., a non-identical binding partner). The method is particularly useful in determining DNA hybridization but may be useful in detecting interaction in any chemical assay.
摘要翻译： 提供了使用微机械装置作为用于检测天然存在的生物聚合物之间的化学相互作用的传感器的方法，所述生物聚合物是不相同的结合配偶体。 无论反应是通过静电力还是其他力发生，该方法都是有用的。 检测到结合配偶体放置在悬臂上可能与分析物分子（即不相同的结合配偶体）反应的诱导的应激，热量或质量变化。 该方法特别可用于确定DNA杂交，但可用于检测任何化学测定中的相互作用。
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