公开(公告)号：US20130045483A1

公开(公告)日：2013-02-21

申请号：US13538089

申请日：2012-06-29

Applicant: SEBASTIAN TREUSCH ,  KENT E.S. MATLACK ,  SUSAN L. LINDQUIST

Inventor： SEBASTIAN TREUSCH ,  KENT E.S. MATLACK ,  SUSAN L. LINDQUIST

IPC: C12N5/071 ,  C12Q1/68 ,  C40B30/06 ,  C12N1/19 ,  C12N5/10

CPC classification number: C12Q1/6883 ,  C07K14/4711 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5017 ,  G01N33/5023 ,  G01N33/6896 ,  G01N2800/2821

Abstract: Disclosed are yeast cells expressing a polypeptide comprising a signal sequence and a human amyloid beta protein. Also disclosed are methods of screening yeast cells to identify compounds that prevent or suppress amyloid beta-induced toxicity and genetic suppressors or enhancers of amyloid beta-induced toxicity. Compounds identified by such screens can be used to treat or prevent neurodegenerative disorders such as Alzheimer's disease.

Abstract translation: 公开了表达包含信号序列和人淀粉样蛋白β蛋白的多肽的酵母细胞。 还公开了筛选酵母细胞以鉴定预防或抑制淀粉样蛋白β-诱导的毒性的化合物和淀粉样蛋白β-诱导的毒性的遗传抑制剂或增强子的方法。 通过这种筛选鉴定的化合物可用于治疗或预防神经变性疾病如阿尔茨海默氏病。

公开(公告)号：US09677079B2

公开(公告)日：2017-06-13

申请号：US13521966

申请日：2011-01-11

Applicant: Kent E. S. Matlack ,  Susan L. Lindquist ,  Sebastian Treusch

Inventor： Kent E. S. Matlack ,  Susan L. Lindquist ,  Sebastian Treusch

IPC: C12N15/81 ,  C07K14/47

CPC classification number: C12N15/81 ,  C07K14/4711

Abstract: Disclosed are yeast cells expressing a polypeptide comprising a signal sequence and a human amyloid beta protein. Also disclosed are methods of screening yeast cells to identify compounds that prevent or suppress amyloid beta-induced toxicity and genetic suppressors or enhancers of amyloid beta-induced toxicity. Compounds identified by such screens can be used to treat or prevent neurodegenerative disorders such as Alzheimer's disease.