公开(公告)号：US20090318786A1

公开(公告)日：2009-12-24

申请号：US12110183

申请日：2008-04-25

申请人： Thomas B. BLANK ,  Timothy L. RUCHTI ,  Stephen L. MONFRE ,  Kevin H. HAZEN ,  Sedar BROWN ,  Christopher SLAWINSKI

发明人： Thomas B. BLANK ,  Timothy L. RUCHTI ,  Stephen L. MONFRE ,  Kevin H. HAZEN ,  Sedar BROWN ,  Christopher SLAWINSKI

IPC分类号： A61B5/1455

CPC分类号： G01N21/359 ,  A61B5/14532 ,  A61B5/1455 ,  A61B2562/146

摘要： Sampling is controlled in order to enhance analyte concentration estimation derived from noninvasive sampling. More particularly, sampling is controlled using controlled fluid delivery to a region between a tip of a sample probe and a tissue measurement site. The controlled fluid delivery enhances coverage of a skin sample site with the thin layer of fluid. Delivery of contact fluid is controlled in terms of spatial delivery, volume, thickness, distribution, temperature, and/or pressure.

摘要翻译： 控制采样以增强从无创采样得到的分析物浓度估计。 更具体地，使用受控流体输送到样品探针的尖端和组织测量部位之间的区域来控制取样。 受控的流体输送增强了皮肤样品位点与薄层流体的覆盖。 在空间传送，体积，厚度，分布，温度和/或压力方面控制接触流体的传送。

公开(公告)号：US20050187439A1

公开(公告)日：2005-08-25

申请号：US11031103

申请日：2005-01-06

申请人： Thomas Blank ,  George Acosta ,  Stephen Monfre ,  Roxanne Abul-Haj ,  Kevin Hazen ,  Sedar Brown ,  Benjamin Richie ,  James Henderson ,  Barry Elliott ,  Josh Hope

发明人： Thomas Blank ,  George Acosta ,  Stephen Monfre ,  Roxanne Abul-Haj ,  Kevin Hazen ,  Sedar Brown ,  Benjamin Richie ,  James Henderson ,  Barry Elliott ,  Josh Hope

IPC分类号： A61B5/00 ,  G01N21/35

CPC分类号： G01N21/359 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/1455 ,  A61B2562/146

摘要： Sampling is controlled to enhance analyte concentration estimation derived from noninvasive sampling. Means of assuring that the same tissue sample volume is repeatably sampled are presented, thus minimizing sampling errors due to mechanical tissue distortion, specular reflectance, and probe placement. In a first embodiment of the invention, sampling is controlled using automated delivery of a coupling fluid to a region between a tip of a sample probe and a tissue measurement site in a manner requiring minimal user interaction. In a second embodiment of the invention, sampling is controlled by controlling temperature variations, preferably with a coupling fluid, at a region about the tip of a sample probe and a sample site. In a third embodiment, sampling is procedurally controlled via timing and location of coupling fluid delivery to a sample site.

摘要翻译： 控制采样以增强从无创采样得到的分析物浓度估计。 呈现确保相同组织样本体积被重复采样的方法，从而最小化由于机械组织变形，镜面反射率和探针放置引起的采样误差。 在本发明的第一实施例中，采用自动化方式将耦合流体以需要最少用户相互作用的方式自动传送到样品探针的尖端和组织测量部位之间的区域进行控制。 在本发明的第二实施例中，通过在围绕样品探针的尖端的区域和样品位置处控制温度变化来控制采样，优选地通过耦合流体进行控制。 在第三实施例中，通过将流体输送到样品位置的定时和位置程序地控制采样。