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1.发明申请ELECTROCHEMICAL METHODS OF DETECTING COLON CANCER CELLS AND USE OF SAME FOR DIAGNOSING AND MONITORING TREATMENT OF THE DISEASE 失效检测结肠癌细胞的电化学方法及其用途，用于诊断和监测疾病的治疗公开(公告)号：US20120288877A1
公开(公告)日：2012-11-15
申请号：US13551642
申请日：2012-07-18
IPC分类号： G01N27/26
CPC分类号： G01N33/5011 , C12Q1/42
摘要： A method of detecting cancer cells is disclosed. The method comprises (a) contacting the cell with a substrate for an enzyme under conditions wherein the enzyme catalyzes a reaction of the cell with the substrate, so as to generate a product capable of producing an electrical signal; and (b) measuring a level of the electrical signal, wherein a difference in a level of the electrical signal compared to a predetermined threshold is indicative of a cancer cell. The method may be adapted for diagnosis, monitoring a cancer therapy, identifying agents capable of treating cancer and individually optimizing a cancer therapy.
摘要翻译： 公开了一种检测癌细胞的方法。 该方法包括：（a）在酶催化细胞与底物的反应的条件下使细胞与酶底物接触，从而产生能产生电信号的产物; 和（b）测量电信号的电平，其中与预定阈值相比较的电信号电平的差异指示癌细胞。 该方法可适用于诊断，监测癌症治疗，鉴定能够治疗癌症并单独优化癌症治疗的药剂。
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2.发明授权公开(公告)号：US08268577B2
公开(公告)日：2012-09-18
申请号：US12379974
申请日：2009-03-05
IPC分类号： C12Q1/42
CPC分类号： G01N33/5011 , C12Q1/42
摘要： A method of detecting cancer cells is disclosed. The method comprises (a) contacting the cell with a substrate for an enzyme under conditions wherein the enzyme catalyzes a reaction of the cell with the substrate, so as to generate a product capable of producing an electrical signal; and (b) measuring a level of the electrical signal, wherein a difference in a level of the electrical signal compared to a predetermined threshold is indicative of a cancer cell. The method may be adapted for diagnosis, monitoring a cancer therapy, identifying agents capable of treating cancer and individually optimizing a cancer therapy.
摘要翻译： 公开了一种检测癌细胞的方法。 该方法包括：（a）在酶催化细胞与底物的反应的条件下使细胞与酶底物接触，从而产生能产生电信号的产物; 和（b）测量电信号的电平，其中与预定阈值相比较的电信号电平的差异指示癌细胞。 该方法可适用于诊断，监测癌症治疗，鉴定能够治疗癌症并单独优化癌症治疗的药剂。
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3.发明申请Methods of detecting cancer cells and use of same for diagnosing and monitoring treatment of the disease 失效检测癌细胞的方法及其用途，用于诊断和监测疾病的治疗公开(公告)号：US20090232740A1
公开(公告)日：2009-09-17
申请号：US12379974
申请日：2009-03-05
IPC分类号： A61K49/00 , G01N33/574 , A61P35/00
CPC分类号： G01N33/5011 , C12Q1/42
摘要： A method of detecting cancer cells is disclosed. The method comprises (a) contacting the cell with a substrate for an enzyme under conditions wherein the enzyme catalyzes a reaction of the cell with said substrate, so as to generate a product capable of producing an electrical signal; and (b) measuring a level of the electrical signal, wherein a difference in a level of said electrical signal compared to a predetermined threshold is indicative of a cancer cell. The method may be adapted for diagnosis, monitoring a cancer therapy, identifying agents capable of treating cancer and individually optimizing a cancer therapy.
摘要翻译： 公开了一种检测癌细胞的方法。 该方法包括（a）在酶催化细胞与所述底物的反应的条件下，使细胞与酶底物接触，从而产生能产生电信号的产物; 和（b）测量电信号的电平，其中所述电信号的电平差与预定阈值相比指示癌细胞。 该方法可适用于诊断，监测癌症治疗，鉴定能够治疗癌症并单独优化癌症治疗的药剂。
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4.发明授权公开(公告)号：US08530179B2
公开(公告)日：2013-09-10
申请号：US13551642
申请日：2012-07-18
IPC分类号： C12Q1/42
CPC分类号： G01N33/5011 , C12Q1/42
摘要： A method of detecting cancer cells is disclosed. The method comprises (a) contacting the cell which is suspicious of a cancerous or undifferentiated phenotype with 4-aminophenyl phosphate (p-APP) under conditions wherein alkaline phosphatase of the cell catalyzes a reaction of the cell with the p-APP, so as to generate a product capable of producing an electrical signal; and (b) measuring a level of the electrical signal, wherein a difference in a level of the electrical signal compared to a predetermined threshold is indicative of a cancer cell.
摘要翻译： 公开了一种检测癌细胞的方法。 该方法包括（a）在细胞的碱性磷酸酶催化细胞与p-APP的反应的条件下，将可疑癌症或未分化表型的细胞与4-氨基苯基磷酸（p-APP）接触，以便 以产生能够产生电信号的产品; 和（b）测量电信号的电平，其中与预定阈值相比较的电信号电平的差异指示癌细胞。
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公开(公告)号：US20090127112A1
公开(公告)日：2009-05-21
申请号：US11920689
申请日：2006-05-18
IPC分类号： G01N33/487 , C12N9/04 , A61K9/00 , A61K38/44
CPC分类号： G01N33/54373 , A61B5/1486 , G01N33/532 , G01N33/68 , G01N33/84 , Y10T428/12493
摘要： Metal-coated proteins, being dissolvable or suspendable in aqueous media and/or retaining a biological activity of the protein, a process and intermediates for preparing same are disclosed. Further disclosed are a pharmaceutical composition containing and a method of treating bacterial and fungal infections utilizing biologically active metal-coated proteins. Conductive elements, electronic circuits containing same, electrodes and biosensor systems utilizing same, and imaging probes, all containing the metal-coated proteins, are also disclosed.
摘要翻译： 公开了金属包覆的蛋白质，其可溶于或悬浮于水性介质中和/或保留蛋白质的生物活性，制备方法和中间体。 还公开了一种药物组合物，其含有利用生物活性金属包被的蛋白质治疗细菌和真菌感染的方法。 还公开了导电元件，含有它们的电子电路，使用它们的电极和生物传感器系统，以及全部含有金属包被的蛋白质的成像探针。
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