公开(公告)号：US20130309169A1

公开(公告)日：2013-11-21

申请号：US13816931

申请日：2011-08-16

申请人： Seok Ki Kim ,  Se Hun Kang ,  Seo Il Kim ,  Young Sang Kim ,  Nam Suk Baek ,  Jin Hee Noh

发明人： Seok Ki Kim ,  Se Hun Kang ,  Seo Il Kim ,  Young Sang Kim ,  Nam Suk Baek ,  Jin Hee Noh

IPC分类号： A61K51/08

CPC分类号： A61K51/081 ,  A61K49/0002 ,  A61K49/0021 ,  A61K49/0034 ,  A61K49/0056 ,  A61K49/006 ,  G01N33/534 ,  G01N2333/765

摘要： The present invention relates to a sentinel lymph node marker comprising an albumin; a radioactive isotope and/or near infrared dye which is bound to the albumin; and a visible dye which is bound to the albumin, a preparation method thereof, a kit for multimode imaging of a sentinel lymph node to prepare the sentinel lymph node marker, and a method for multimode imaging of a sentinel lymph node using the same. The sentinel lymph node marker of the invention remains in the sentinel lymph node for a long period of time and allows for multimode imaging of the sentinel lymph node. Thus, using this marker the sentinel lymph node can be accurately identified in vivo by near infrared imaging and/or gamma imaging without incision of skin, and the location of the identified sentinel lymph node can be precisely identified with the naked eye during a surgical operation of removing the identified sentinel lymph node.

摘要翻译： 本发明涉及包含白蛋白的前哨淋巴结标记物; 与白蛋白结合的放射性同位素和/或近红外染料; 和与白蛋白结合的可见染料，其制备方法，用于制备前哨淋巴结标志物的前哨淋巴结的多模成像的试剂盒，以及使用其的前哨淋巴结的多模成像的方法。 本发明的前哨淋巴结标志物长期保留在前哨淋巴结中，并允许前哨淋巴结的多模成像。 因此，使用该标记物可以通过近红外成像和/或γ成像在体内精确地识别前哨淋巴结而无需切开皮肤，并且可以在外科手术期间用肉眼精确地识别所识别的前哨淋巴结的位置 去除鉴定的前哨淋巴结。

公开(公告)号：US10881750B2

公开(公告)日：2021-01-05

申请号：US13816931

申请日：2011-08-16

申请人： Seok Ki Kim ,  Se Hun Kang ,  Seo Il Kim ,  Young Sang Kim ,  Nam Suk Baek ,  Jin Hee Noh

发明人： Seok Ki Kim ,  Se Hun Kang ,  Seo Il Kim ,  Young Sang Kim ,  Nam Suk Baek ,  Jin Hee Noh

IPC分类号： A61K51/08 ,  A61K49/00 ,  G01N33/534

摘要： The present invention relates to a sentinel lymph node marker comprising an albumin; a radioactive isotope and/or near infrared dye which is bound to the albumin; and a visible dye which is bound to the albumin, a preparation method thereof, and a kit for multimode imaging of a sentinel lymph node to prepare the sentinel lymph node marker. The sentinel lymph node marker of the invention remains in the sentinel lymph node for a long period of time and allows for multimode imaging of the sentinel lymph node. Thus, using this marker the sentinel lymph node can be accurately identified in vivo by near infrared imaging and/or gamma imaging without incision of skin, and the location of the identified sentinel lymph node can be precisely identified with the naked eye during a surgical operation of removing the identified sentinel lymph node.