公开(公告)号：US06514689B2

公开(公告)日：2003-02-04

申请号：US09839993

申请日：2001-04-20

申请人： In Suk Han ,  Jules John Magda ,  Seok Lew Lew ,  Young San Jean

发明人： In Suk Han ,  Jules John Magda ,  Seok Lew Lew ,  Young San Jean

IPC分类号： C12Q100

CPC分类号： A61B5/14865 ,  A61B5/0022 ,  A61B5/14532 ,  C12Q1/001 ,  C12Q1/006 ,  G01N7/00 ,  G01N13/04 ,  G01N33/54373 ,  G01N2001/021

摘要： A biosensor (10) has a hydrogel (30) in a rigid and preferably biocompatible enclosure (20). The hydrogel (30) includes an immobilized analyte binding molecule (ABM) and an immobilized analyte. The immobilized analyte competitively binds with free analyte to the ABM, thus changing the number of crosslinks in the hydrogel (30), which changes hydrogel swelling tendency (and thus the osmotic pressure) in its confined space in proportion to the concentration of free analyte concentration. By measuring the change in hydrogel pressure with a pressure transducer (40), the biosensor (10) is able to accurately measure the concentration of the free analyte molecule without the problem of oxygen limitations and interference encountered by prior art biosensors. A battery (64) powered telemeter (60) operably engaged to the pressure transducer (40) sends a radio data signal to a receiver (66) containing an alarm system operably attached to a computer (62). Furthermore, an alarm system utilizes such a sensor to automatically notify a person that the analyte level is outside desired predetermined parameters, and/or to automatically inject an agent to counteract the adverse analyte levels.

摘要翻译： 生物传感器（10）在刚性且优选生物相容的外壳（20）中具有水凝胶（30）。 水凝胶（30）包括固定的分析物结合分子（ABM）和固定的分析物。 固定化分析物与游离分析物竞争性地结合到ABM，从而改变水凝胶中的交联数（30），其在受限空间中的水凝胶膨胀趋势（因此渗透压）与游离分析物浓度的比例 。 通过使用压力传感器（40）测量水凝胶压力的变化，生物传感器（10）能够精确地测量游离的分析物分子的浓度，而不存在现有技术生物传感器遇到的氧限制和干扰的问题。 可操作地接合到压力传感器（40）的电池（64）供电的遥测仪（60）将无线电数据信号发送到容纳可操作地附接到计算机（62）的报警系统的接收器（66）。 此外，报警系统利用这种传感器来自动通知一个人分析物水平在期望的预定参数之外，和/或自动地注入一个试剂以抵消不利的分析物水平。

公开(公告)号：US06835553B2

公开(公告)日：2004-12-28

申请号：US10120870

申请日：2002-04-11

申请人： In Suk Han ,  Seok Lew ,  Man Hee Han

发明人： In Suk Han ,  Seok Lew ,  Man Hee Han

IPC分类号： C12G154

CPC分类号： G01N33/66 ,  A61B5/0022 ,  A61B5/14532 ,  C12Q1/001 ,  C12Q1/006 ,  G01N7/00 ,  G01N13/04 ,  Y10T436/144444

摘要： An implantable biosensor for detecting an analyte in vivo in body fluids comprises an analyte-sensitive hydrogel filament chemically configured to vary its displacement volume according to changes in concentration of an analyte, such as glucose, in a patient's body fluid. A photometric displacement transducer placed inside the biosensor is configured to quantifiably detect changes in the displacement volume of the hydrogel filament, such as by detecting the light intensity on a photoreceptor arranged to receive light of varying intensity depending upon the displacement of the hydrogel filament. A battery powered telemeter operably engaged to the photometric displacement transducer sends a radio data signal representing glucose concentration level to a receiver containing an alarm system. The alarm system can automatically notify a person that the analyte level is outside desired predetermined parameters, and/or to automatically inject an agent to counteract the adverse analyte levels.

摘要翻译： 用于检测体液中体内分析物的可植入生物传感器包括化学配置为根据患者体液中分析物（例如葡萄糖）的浓度变化来改变其置换体积的分析物敏感水凝胶丝。 放置在生物传感器内部的光度位移传感器被配置为可定量地检测水凝胶丝的位移体积的变化，例如通过检测被布置为接收不同强度的光的感光器上的光强度，这取决于水凝胶丝的位移。 可操作地接合到光度位移传感器的电池供电的遥测仪将表示葡萄糖浓度水平的无线电数据信号发送到包含报警系统的接收器。 报警系统可以自动通知人员分析物水平在所需的预定参数之外，和/或自动注射试剂以抵消不利的分析物水平。

公开(公告)号：US06751491B2

公开(公告)日：2004-06-15

申请号：US10054660

申请日：2002-01-22

申请人： Seok Lew ,  In Suk Han

发明人： Seok Lew ,  In Suk Han

IPC分类号： A61B505

CPC分类号： A61B5/14865 ,  A61B5/0031 ,  A61B5/14539 ,  A61B5/14546

摘要： An implantable chip biosensor for detecting an analyte in vivo in body fluids comprises an analyte-sensitive hydrogel slab chemically configured to vary its displacement volume according to changes in concentration of an analyte, such as glucose, in a patient's body fluid, the slab being disposed in a groove in a support block. The biosensor chip is ‘read’ by an external scanner configured to quantifiably detect changes in the displacement volume of the hydrogel slab. The support block is made of rigid or semi-rigid support material to restrain expansion of the hydrogel in all but one dimension, and the groove has one or more openings covered with a semipermeable membrane to allow contact between the patient's body fluid and the hydrogel. The scanning means may be any type of imaging devices such as an ultrasound scanner, a magnetic resonance imager (MRI), or a computerized tomographic scanner (CT) capable of resolving changes in the slab's dimensions.

摘要翻译： 用于检测体液中体内分析物的可植入芯片生物传感器包括化学配置为根据患者体液中分析物（例如葡萄糖）的浓度变化来改变其置换体积的分析物敏感水凝胶板， 在支撑块中的凹槽中。 生物传感器芯片被配置成可量化地检测水凝胶板的排量的变化的外部扫描器“读取”。 支撑块由刚性或半刚性支撑材料制成，以在除了一个维度之外的所有部分中抑制水凝胶的膨胀，并且凹槽具有覆盖有半透膜的一个或多个开口以允许患者的体液与水凝胶之间的接触。 扫描装置可以是能够解决板的尺寸变化的任何类型的成像装置，例如超声波扫描仪，磁共振成像器（MRI）或计算机断层扫描仪（CT）。