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    System for improving cardiac function by sealing a partitioning membrane within a ventricle
    1.
    发明授权
    System for improving cardiac function by sealing a partitioning membrane within a ventricle 有权
    通过密封心室内的分隔膜来改善心脏功能的系统

    公开(公告)号：US08388672B2

    公开(公告)日：2013-03-05

    申请号：US12422144

    申请日：2009-04-10

    申请人： Alexander Khairkhahan ,  Serjan D. Nikolic ,  Hugh R. Sharkey

    发明人： Alexander Khairkhahan ,  Serjan D. Nikolic ,  Hugh R. Sharkey

    IPC分类号： A61F2/06 ,  A61M29/08

    CPC分类号： A61F2/2487 ,  A61B17/0057 ,  A61B17/12022 ,  A61B17/12122 ,  A61B17/1214 ,  A61B17/12172 ,  A61B17/12195 ,  A61B2017/00243 ,  A61B2017/00557 ,  A61B2017/00575 ,  A61B2017/00579 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00601 ,  A61B2017/00615 ,  A61B2017/00632 ,  A61B2017/00867 ,  A61B2017/0649 ,  A61B2017/12095

    摘要： Partitioning devices that may be secured and sealed within a heart chamber for separating a patient's heart chamber into a productive portion and a non-productive portion are described herein. The partitioning devices described herein may include a reinforced membrane with outwardly biased members. The reinforced membrane may have a central hub with a distally extending support stem with a plurality of feet which extend radially from a centerline axis and preferably have ends that are aligned in a common plane. These devices may be secured within the heart chamber by sealing them to the wall of the heart chamber, for example, by inflating an inflatable element on the periphery of the device. The non-productive portion may be filled with a material, including occlusive materials. Sealing and/or filling the non-productive portion formed by the devices described herein may help prevent leakage from the non-productive region. Also described herein are systems including these devices and methods of using them, which may be suitable for treating patients with heart disease, particularly congestive heart failure.

    摘要翻译： 本文描述了可以在心室内固定和密封以将患者的心室分离成生产部分和非生产性部分的分隔装置。 本文所述的分隔装置可以包括具有向外偏置构件的增强膜。 增强膜可以具有中心毂，其具有远端延伸的支撑杆，其具有从中心线轴线径向延伸的多个脚，并且优选地具有在公共平面中对准的端部。 这些装置可以通过将它们密封到心室的壁来固定在心脏腔室内，例如通过使装置的周边上的可充气元件膨胀。 非生产性部分可以填充材料，包括封闭材料。 密封和/或填充由本文所述的装置形成的非生产性部分可以有助于防止从非生产性区域泄漏。 本文还描述了包括这些装置和使用它们的方法的系统，其可适用于治疗心脏病患者，特别是充血性心力衰竭。

    Method of improving cardiac function using a porous membrane
    3.
    发明授权
    Method of improving cardiac function using a porous membrane 有权
    使用多孔膜改善心脏功能的方法

    公开(公告)号：US07887477B2

    公开(公告)日：2011-02-15

    申请号：US10302272

    申请日：2002-11-22

    申请人： Serjan D. Nikolic ,  Hugh R. Sharkey

    发明人： Serjan D. Nikolic ,  Hugh R. Sharkey

    IPC分类号： A61N1/362

    CPC分类号： A61B17/0057 ,  A61B17/12022 ,  A61B17/12122 ,  A61B17/12172 ,  A61B2017/00004 ,  A61B2017/00243 ,  A61B2017/00597 ,  A61B2017/00632 ,  A61B2017/00668 ,  A61B2017/1205 ,  A61F2/2442 ,  A61N1/05

    摘要： A porous membrane is inserted into a ventricle of a heart. The porous membrane creates a relatively hemostatic volume in which a thrombus can grow. Blood can still pass through fenestrations of the membrane into and out of the hemostatic volume. The fenestrations reduce pressures that act on the membrane, and so reduce stresses within the membrane. The flow characteristics through the hemostatic volume promote growth of the thrombus from a base of the hemostatic volume. The thrombus grows to slightly larger than the original size of the hemostatic volume so as to provide support for the membrane. Any remaining stresses within the membrane are thereby substantially eliminated. The thrombus shrinks over an ensuing period of time, with the membrane merely acting as a barrier to which an outer wall of the myocardium retracts. The function of the membrane is then complete, and may be absorbed.

    摘要翻译： 将多孔膜插入心脏的心室。 多孔膜产生血栓可以生长的相对止血体积。 血液仍然可以通过膜的开窗进入和离开止血体积。 开窗减少作用在膜上的压力，从而减少膜内的应力。 通过止血体积的流动特性促进血栓从止血体积的基底生长。 血栓生长到略大于止血体积的原始尺寸，以便为膜提供支撑。 从而基本上消除了膜内的任何剩余应力。 血栓在随后的一段时间内收缩，膜仅作为心肌外壁缩回的屏障。 然后膜的功能完成，可以被吸收。

    SYSTEM FOR IMPROVING CARDIAC FUNCTION BY SEALING A PARTITIONING MEMBRANE WITHIN A VENTRICLE
    5.
    发明申请
    SYSTEM FOR IMPROVING CARDIAC FUNCTION BY SEALING A PARTITIONING MEMBRANE WITHIN A VENTRICLE 有权
    通过密封隔离膜在心脏中改善心脏功能的系统

    公开(公告)号：US20090254195A1

    公开(公告)日：2009-10-08

    申请号：US12422144

    申请日：2009-04-10

    申请人： Alexander Khairkhahan ,  Serjan D. Nikolic ,  Hugh R. Sharkey

    发明人： Alexander Khairkhahan ,  Serjan D. Nikolic ,  Hugh R. Sharkey

    IPC分类号： A61F2/04

    CPC分类号： A61F2/2487 ,  A61B17/0057 ,  A61B17/12022 ,  A61B17/12122 ,  A61B17/1214 ,  A61B17/12172 ,  A61B17/12195 ,  A61B2017/00243 ,  A61B2017/00557 ,  A61B2017/00575 ,  A61B2017/00579 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00601 ,  A61B2017/00615 ,  A61B2017/00632 ,  A61B2017/00867 ,  A61B2017/0649 ,  A61B2017/12095

    摘要： Partitioning devices that may be secured and sealed within a heart chamber for separating a patient's heart chamber into a productive portion and a non-productive portion are described herein. The partitioning devices described herein may include a reinforced membrane with outwardly biased members. The reinforced membrane may have a central hub with a distally extending support stem with a plurality of feet which extend radially from a centerline axis and preferably have ends that are aligned in a common plane. These devices may be secured within the heart chamber by sealing them to the wall of the heart chamber, for example, by inflating an inflatable element on the periphery of the device. The non-productive portion may be filled with a material, including occlusive materials. Sealing and/or filling the non-productive portion formed by the devices described herein may help prevent leakage from the non-productive region. Also described herein are systems including these devices and methods of using them, which may be suitable for treating patients with heart disease, particularly congestive heart failure.

    摘要翻译： 本文描述了可以在心室内固定和密封以将患者的心室分离成生产部分和非生产性部分的分隔装置。 本文所述的分隔装置可以包括具有向外偏置构件的增强膜。 增强膜可以具有中心毂，其具有远端延伸的支撑杆，其具有从中心线轴线径向延伸的多个脚，并且优选地具有在公共平面中对准的端部。 这些装置可以通过将它们密封到心室的壁来固定在心脏腔室内，例如通过使装置的周边上的可充气元件膨胀。 非生产性部分可以填充材料，包括封闭材料。 密封和/或填充由本文所述的装置形成的非生产性部分可以有助于防止从非生产性区域泄漏。 本文还描述了包括这些装置和使用它们的方法的系统，其可适用于治疗心脏病患者，特别是充血性心力衰竭。

    Peripheral seal for a ventricular partitioning device
    6.
    发明授权
    Peripheral seal for a ventricular partitioning device 有权
    心室分隔装置的外围密封

    公开(公告)号：US07582051B2

    公开(公告)日：2009-09-01

    申请号：US11151164

    申请日：2005-06-10

    申请人： Alexander Khairkhahan ,  Hugh R. Sharkey ,  Serjan D. Nikolic ,  Branislav Radovancevic

    发明人： Alexander Khairkhahan ,  Hugh R. Sharkey ,  Serjan D. Nikolic ,  Branislav Radovancevic

    IPC分类号： A61F2/00

    CPC分类号： A61B17/12022 ,  A61B17/12122 ,  A61B17/12172 ,  A61B17/1219 ,  A61B2017/00243 ,  A61B2017/12095 ,  A61B2017/22061

    摘要： A partitioning device for separating a patient's heart chamber into a productive portion and a non-productive portion which is suitable for treating patients with heart disease, particularly congestive heart failure. The partitioning device has a reinforced membrane with outwardly biased members to help seal the periphery of the membrane against the wall of the patient's heart chamber. In one embodiment, the outwardly biased member is an expansive strand that extends between adjacent ribs of an expandable frame which reinforces the membrane. In another embodiment, the outwardly biased member is a hydrophilic body such as foam which swells upon contact with body fluid such as blood in the heart chamber. The reinforced membrane has a central hub with a distally extending support stem with a plurality of feet which extend radially from a centerline axis and preferably have ends that are aligned in a common plane. The ends of the pods which extend radially away from the centerline axis may be interconnected by flexible struts and/or webs.

    摘要翻译： 一种用于将患者心室分离为生产部分和非生产性部分的分配装置，其适用于治疗患有心脏病，特别是充血性心力衰竭的患者。 分隔装置具有增强的膜，其具有向外偏置的构件，以帮助将膜的周边密封抵靠患者心室的壁。 在一个实施例中，向外偏置的构件是在可扩展框架的相邻肋之间延伸的膨胀股线，其可加强膜。 在另一个实施方案中，向外偏压的构件是亲水体，例如泡沫，当与心液室中的体液如血液接触时膨胀。 加强膜具有中心毂，其具有远端延伸的支撑杆，多个脚从中心线径向延伸，并且优选地具有在公共平面中对准的端部。 从径向远离中心线轴线延伸的荚的端部可通过柔性支柱和/或腹板相互连接。

    System and method to monitor the heart of a patient
    9.
    发明授权
    System and method to monitor the heart of a patient 失效
    用于监测患者心脏的系统和方法

    公开(公告)号：US5743267A

    公开(公告)日：1998-04-28

    申请号：US549375

    申请日：1995-10-27

    申请人： Serjan D. Nikolic ,  Gary Feierbach

    发明人： Serjan D. Nikolic ,  Gary Feierbach

    IPC分类号： A61B5/00 ,  A61B5/0215

    CPC分类号： A61B5/0215 ,  A61B5/0028 ,  A61B5/0031 ,  A61B5/7239 ,  Y10S128/903

    摘要： A system and method for monitoring a physiological attribute of a patient is disclosed. The system includes a measuring device to measure an absolute physiological attribute of a patient and to generate an absolute physiological attribute signal. The present invention also includes a processing element to receive the measured absolute physiological attribute signal. The processing element then generates a filtered physiological attribute signal by substantially removing the effects of certain bodily functions from the absolute physiological attribute signal and other artifacts of measurement. The processor also generates a set of parameters derived from the filtered physiological attribute signal which are indicative of the health and condition of the patient.

    摘要翻译： 公开了一种用于监测患者的生理属性的系统和方法。 该系统包括用于测量患者的绝对生理属性并产生绝对生理属性信号的测量装置。 本发明还包括用于接收所测量的绝对生理属性信号的处理元件。 然后，处理元件通过从绝对生理属性信号和其他测量伪像基本上去除某些身体功能的影响来生成滤波的生理属性信号。 处理器还生成从过滤的生理属性信号导出的参数集合，其指示患者的健康状况和状况。