公开(公告)号：US20180179561A1

公开(公告)日：2018-06-28

申请号：US15737021

申请日：2016-06-22

Applicant: Serturner Corp.

Inventor： Peter James Facchini ,  Jillian Hagel

IPC: C12P13/00

CPC classification number: C12P13/001 ,  C07C213/08 ,  C12N9/1007 ,  C12Y201/01 ,  C07C215/30

Abstract: Methods for making alkaloid compounds, including ephedrine and derivatives thereof. The methods involve the performance of an N-methyltransferase catalyzed chemical reaction.

公开(公告)号：US20190194269A1

公开(公告)日：2019-06-27

申请号：US16312895

申请日：2017-06-27

Applicant: INTREXON CORPORATION ,  SERTURNER CORP.

Inventor： Peter James FACCHINI ,  Joseph E. TUCKER

IPC: C07K14/415 ,  C12P17/18 ,  C12P17/12 ,  C12N15/81 ,  C12N15/82

CPC classification number: C07K14/415 ,  C12N9/00 ,  C12N15/52 ,  C12N15/80 ,  C12N15/81 ,  C12N15/8261 ,  C12P17/12 ,  C12P17/18

Abstract: Polynucleotides and polypeptides useful in the manufacture of a class of chemical compounds known as alkaloids are provided. The polynucleotides and polypeptides may be used to synthesize alkaloids, including reticuline, thebaine and morphine, in vivo and in vitro. The polynucleotides further may be used to examine the presence of the polynucleotides in a cell or a cell extract, and to modulate expression thereof in living cells.