公开(公告)号：US20090287755A1

公开(公告)日：2009-11-19

申请号：US12274376

申请日：2008-11-20

申请人： Jae Kwang Kim ,  Jee Hyong Lee ,  Tae Bok Yoon ,  Dong Moon Kim ,  Jung Hoon Kim ,  Dong Hoon Lee ,  Kun Su Kim ,  Je Hee Jung ,  Seung Hoo Lee ,  Kwang Ho Yoon

发明人： Jae Kwang Kim ,  Jee Hyong Lee ,  Tae Bok Yoon ,  Dong Moon Kim ,  Jung Hoon Kim ,  Dong Hoon Lee ,  Kun Su Kim ,  Je Hee Jung ,  Seung Hoo Lee ,  Kwang Ho Yoon

IPC分类号： G06F17/15 ,  G06F7/32

CPC分类号： G16B30/00

摘要： Disclosed is a sequence similarity measuring apparatus and a method of controlling the same. The sequence similarity measuring apparatus using dynamic programming includes: a matrix generating unit for generating a matrix based on the dynamic programming by using two sequences; a normalization unit for calculating a similarity reference value by inputting an element value of a last row/column of the matrix generated by the matrix generating unit into a normalization formula for a given sequence length; and a similarity measuring unit for measuring predefined sequence similarity between the two sequences, based on the similarity reference value calculated by the normalization unit. This makes it possible to easily and correctly achieve similarity comparison between multiple sequences, and thus this technology is expected to be widely utilized in biology/programming application fields.

摘要翻译： 公开了一种序列相似性测量装置及其控制方法。 使用动态规划的序列相似度测量装置包括：矩阵生成单元，用于通过使用两个序列来生成基于动态规划的矩阵; 归一化单元，用于通过将由矩阵生成单元生成的矩阵的最后一行/列的元素值输入给定序列长度的归一化公式来计算相似度基准值; 以及相似度测量单元，用于基于归一化单元计算的相似性参考值来测量两个序列之间的预定义序列相似性。 这使得可以容易且正确地实现多个序列之间的相似性比较，因此该技术预期将在生物学/编程应用领域被广泛使用。

公开(公告)号：US20060281678A1

公开(公告)日：2006-12-14

申请号：US11321186

申请日：2005-12-29

申请人： Je-Ho Lee ,  Seung-Hoo Lee

发明人： Je-Ho Lee ,  Seung-Hoo Lee

IPC分类号： A61K38/17 ,  A61K48/00

CPC分类号： C07K14/57581 ,  A61K38/00 ,  A61K48/00 ,  C12N15/86 ,  C12N2710/10343

摘要： The present invention relates to a novel use of thymosin β10 protein for anti-angiogenesis, anti-tumor progression, and anti-metastasis by targeting a Ras signaling pathway. Particularly, thymosin β10 protein reduces the generation of a Ras-GTP/Raf complex by sequestering Ras-GTP or by interfering with the binding of Ras-GTP to Raf through a direct interaction with Ras, resulting in the inhibition of autocrine and paracrine production of VEGF. Therefore, thymosin β10 protein of the present invention can be effectively used to treat disease conditions associated with angiogenesis, tumor progression, and/or metastasis, particularly those caused by the activation of the Ras signaling pathway, such as solid tumors, rheumatoid arthritis, psoriasis, and diabetic retinopathy.

摘要翻译： 本发明涉及通过靶向Ras信号传导途径来增加胸腺素β10 N蛋白的抗血管生成，抗肿瘤进展和抗转移的新用途。 特别地，胸腺素β10蛋白通过螯合Ras-GTP或通过与Ras的直接相互作用干扰Ras-GTP与Raf的结合来减少Ras-GTP / Raf复合物的产生，导致 抑制VEGF的自分泌和旁分泌生成。 因此，本发明的胸腺素β10蛋白可以有效地用于治疗与血管发生，肿瘤进展和/或转移相关的疾病状况，特别是由Ras信号传导途径激活引起的疾病。 作为实体瘤，类风湿性关节炎，牛皮癣和糖尿病性视网膜病变。