公开(公告)号：US06319518B1

公开(公告)日：2001-11-20

申请号：US08919957

申请日：1997-08-29

申请人： Seung-Seo Lee ,  Sung-Bum La ,  Chang-Baeg Lim ,  Sujung Lee ,  Bo-Youn Seo ,  Chaul-Min Pai

发明人： Seung-Seo Lee ,  Sung-Bum La ,  Chang-Baeg Lim ,  Sujung Lee ,  Bo-Youn Seo ,  Chaul-Min Pai

IPC分类号： A61K922

CPC分类号： A61K9/4816 ,  A61K9/286 ,  A61K9/5036

摘要： A composition comprising gelatin and a polysaccharide which is degradable by a colonic enzyme and, optionally, with an aldehyde and/or a polyvalent metal ion and/or an additional polysaccharide, which is not degraded or disintegrated in the upper gastrointestinal tract, thereby rendering the active substance loaded therein to be selectively delivered to the colon and to be effectively released in the colon.

摘要翻译： 一种包含明胶和多糖的组合物，其可以通过结肠酶和任选的醛和/或多价金属离子和/或另外的多糖降解，其在上胃肠道中不会降解或分解，从而使 载入其中的活性物质被选择性地递送到结肠并且有效地释放在结肠中。

公开(公告)号：US20230372492A1

公开(公告)日：2023-11-23

申请号：US18247049

申请日：2021-09-29

申请人： Joo Youn PARK ,  Keun Seok SEO ,  Seung Seo LEE

发明人： Joo Youn PARK ,  Keun Seok SEO ,  Seung Seo LEE

IPC分类号： A61K47/54 ,  A61P31/04

CPC分类号： A61K47/549 ,  A61P31/04

摘要： A drug conjugate, composition, and method for delivering active antimicrobials based on existing antibiotics through a hexose phosphate transporter (UhpT) by conjugating the antimicrobials with non-metabolizable hexose phosphates. Methods of co-administering antibiotics with non-metabolizable hexose phosphates as antimicrobials are also disclosed. Non-metabolizable hexose phosphates can constitutively and strongly induce expression of UhpT which significantly improves the efficacy and/or antimicrobial spectrum of antibiotics. This drug conjugate, composition and method will permit reuse of many FDA approved antibiotics that have been abandoned or fallen into disuse due to their current low efficacy and/or resistance to these antibiotics by pathogens.

公开(公告)号：US06413494B1

公开(公告)日：2002-07-02

申请号：US09318579

申请日：1999-05-25

申请人： Seung Seo Lee ,  Chang Baeg Lim ,  Chaul Min Pai ,  Sujung Lee ,  In Park ,  Moon Gun Seo ,  Heenam Park

发明人： Seung Seo Lee ,  Chang Baeg Lim ,  Chaul Min Pai ,  Sujung Lee ,  In Park ,  Moon Gun Seo ,  Heenam Park

IPC分类号： A61K4900

CPC分类号： A61K9/5078 ,  A61K9/286 ,  A61K9/4816 ,  A61K9/4891 ,  A61K9/5036 ,  C08L5/06 ,  Y10S514/96 ,  Y10S514/962 ,  C08L2666/02

摘要： A colonic drug delivery composition contains a first polysaccharide and a second polysaccharide wherein both polysaccharide are degradable by colonic enzymes and are mixed at a environmental pH of about 7 or above, without use of a cross-linking agent. A colon selective pharmaceutical composition and dosage form for oral delivery of a drug, diagnostic reagent, or mixture thereof includes the drug, diagnostic reagent, or mixture thereof in contact with the polysaccharide composition. A method of preparing such a colonic drug delivery composition and the colon selective pharmaceutical composition and dosage from are also disclosed.

摘要翻译： 结肠药物递送组合物包含第一多糖和第二多糖，其中两种多糖可通过结肠酶降解，并且在环境pH约为7或更高的条件下混合，而不使用交联剂。 用于口服递送药物，诊断试剂或其混合物的结肠选择性药物组合物和剂型包括与多糖组合物接触的药物，诊断试剂或其混合物。 还公开了制备这种结肠药物递送组合物和结肠选择性药物组合物和剂量的方法。