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公开(公告)号：US20100160354A1
公开(公告)日：2010-06-24
申请号：US12717349
申请日：2010-03-04
IPC分类号： A61K31/522 , A61P9/00 , A61P7/12 , A61P3/04 , A61P3/06
CPC分类号： C07D473/06 , C07D473/04
摘要： The present invention relates to therapeutically active xanthine derivative compounds of Formula (I): corresponding processes for manufacture of said derivatives, pharmaceutical formulations containing and uses of such compounds in therapy, particularly in treatment of diseases where under-activation of the HM74A receptor contributes to the disease or where activation of the receptor will be beneficial.
摘要翻译： 本发明涉及式（I）的治疗活性黄嘌呤衍生物化合物：用于制备所述衍生物的相应方法，含有这些化合物在治疗中的药物制剂，以及其用途，特别是治疗HM74A受体活化不足的疾病 该疾病或受体的激活将是有益的。
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公开(公告)号：US20080214638A1
公开(公告)日：2008-09-04
申请号：US11815402
申请日：2006-02-14
IPC分类号： A61K31/41 , C07C229/00 , A61K31/19 , A61P29/00 , A61P9/00 , C07D257/04
CPC分类号： C07D257/04 , C07C235/24
摘要： Therapeutically active anthranilic acid derivatives of Formula (I) or of Formula (Ia) wherein R, R1, R2 and Z are as defined in the specification, processes for the preparation of said derivatives, pharmaceutical formulations containing the active compounds and the use of the compounds in therapy, particularly in the treatment of diseases in which under-activation of the HM74A receptor contributes to the disease or in which activation of the receptor will be beneficial, are disclosed.
摘要翻译： 式（I）或式（Ia）的其中R，R 1，R 2和Z如本说明书中所定义的式（I）或式（Ia）的治疗活性的邻氨基苯甲酸衍生物 所述衍生物的制备，含有活性化合物的药物制剂和该化合物在治疗中的用途，特别是用于治疗HM74A受体的未激活有助于疾病或受体激活将是有益的疾病， 被披露。
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公开(公告)号：US20130150383A1
公开(公告)日：2013-06-13
申请号：US13760423
申请日：2013-02-06
IPC分类号： A61K31/522
CPC分类号： C07D473/06 , C07D473/04
摘要： The present invention relates to therapeutically active xanthine derivative compounds of Formula (I): corresponding processes for manufacture of said derivatives, pharmaceutical formulations containing and uses of such compounds in therapy, particularly in treatment of diseases where under-activation of the HM74A receptor contributes to the disease or where activation of the receptor will be beneficial.
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4.发明授权HM74 receptor agonists:xanthine derivatives, corresponding pharmaceutical compositions, treatment methods and processes 有权HM74受体激动剂：黄嘌呤衍生物，相应的药物组合物，治疗方法和方法公开(公告)号：US08394808B2
公开(公告)日：2013-03-12
申请号：US12552649
申请日：2009-09-02
IPC分类号： C07D473/06 , A61K31/522 , A61P9/10 , A61P3/06 , A61P3/10
CPC分类号： C07D473/06 , C07D473/04
摘要： The present invention relates to therapeutically active xanthine derivative compounds of Formula (I): corresponding processes for manufacture of said derivatives, pharmaceutical formulations containing and uses of such compounds in therapy, particularly in treatment of diseases where under-activation of the HM74A receptor contributes to the disease or where activation of the receptor will be beneficial.
摘要翻译： 本发明涉及式（I）的治疗活性黄嘌呤衍生物化合物：用于制备所述衍生物的相应方法，含有这些化合物在治疗中的药物制剂，以及其用途，特别是治疗HM74A受体活化不足的疾病 该疾病或受体的激活将是有益的。
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公开(公告)号：US20100010021A1
公开(公告)日：2010-01-14
申请号：US12552649
申请日：2009-09-02
IPC分类号： A61K31/522 , C07D473/04
CPC分类号： C07D473/06 , C07D473/04
摘要： The present invention relates to therapeutically active xanthine derivative compounds of Formula (I): corresponding processes for manufacture of said derivatives, pharmaceutical formulations containing and uses of such compounds in therapy, particularly in treatment of diseases where under-activation of the HM74A receptor contributes to the disease or where activation of the receptor will be beneficial.
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公开(公告)号：US08268839B2
公开(公告)日：2012-09-18
申请号：US12717349
申请日：2010-03-04
IPC分类号： A61P3/10 , C07D473/06 , A61K31/522 , A61P3/06 , A61P9/10
CPC分类号： C07D473/06 , C07D473/04
摘要： The present invention relates to therapeutically active xanthine derivative compounds of Formula (I): corresponding processes for manufacture of said derivatives, pharmaceutical formulations containing and uses of such compounds in therapy, particularly in treatment of diseases where under-activation of the HM74A receptor contributes to the disease or where activation of the receptor will be beneficial.
摘要翻译： 本发明涉及式（I）的治疗活性黄嘌呤衍生物化合物：用于制备所述衍生物的相应方法，含有这些化合物在治疗中的药物制剂，以及其用途，特别是治疗HM74A受体活化不足的疾病 该疾病或受体的激活将是有益的。
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公开(公告)号：US20100179128A1
公开(公告)日：2010-07-15
申请号：US12063432
申请日：2006-08-08
申请人： Richard Jonathan Daniel Hatley , Jag Paul Heer , John Liddle , Andrew McMurtrie Mason , Ivan Leo Pinto , Shahzad Sharooq Rahman , Ian Edward David Smith
发明人： Richard Jonathan Daniel Hatley , Jag Paul Heer , John Liddle , Andrew McMurtrie Mason , Ivan Leo Pinto , Shahzad Sharooq Rahman , Ian Edward David Smith
IPC分类号： A61K31/55 , C07D473/04 , A61K31/522 , C07D519/00 , A61K31/5377 , A61P3/06 , A61P3/10 , A61P3/04 , A61P9/04 , A61P9/10 , A61P7/02 , A61P13/12
CPC分类号： C07D473/04 , C07D473/06
摘要： The present invention relates to compounds of formula (I) which are xanthine derivatives, processes for the manufacture of said derivatives, pharmaceutical formulations containing these active compounds and the use of the compounds in therapy, for example, in the treatment of diseases where under-activation of the HM74A receptor contributes to the disease or where activation of the receptor will be beneficial
摘要翻译： 本发明涉及作为黄嘌呤衍生物的式（I）化合物，制备所述衍生物的方法，含有这些活性化合物的药物制剂，以及该化合物在治疗中的用途，例如， HM74A受体的激活有助于该疾病或受体活化将是有益的
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8.发明授权公开(公告)号：US07220769B2
公开(公告)日：2007-05-22
申请号：US10868090
申请日：2004-06-14
IPC分类号： A61K31/4188 , A61K31/4184 , C07D491/02
CPC分类号： C07D235/02 , C07D235/18 , C07D401/12 , C07D403/12 , C07D409/04 , C07D409/14 , C07D453/02 , C07D471/04 , C07D473/00
摘要： A compound of formula (I) or a salt thereof, or a solvate thereof, wherein: X represents oxygen, sulphur, or NRb; Y and Z each independently represent nitrogen, CH, CR1 or CR2; A represents an unsubstituted or substituted aryl group or an unsubstituted or substituted heterocyclyl group; Ra represents —C(O)NRsRt; R1 and R2 each independently represents hydrogen or specific substituents; and the use of such a compound in the treatment and/or prophylaxis of diseases associated with over activity of osteoclasts in mammals.
摘要翻译： 式（I）化合物或其盐或其溶剂化物，其中：X表示氧，硫或NR b; Y和Z各自独立地表示氮，CH，CR 1或CR 2; A表示未取代或取代的芳基或未取代或取代的杂环基; R a表示-C（O）NR S R t; R 1和R 2各自独立地表示氢或特定取代基; 以及这种化合物在治疗和/或预防与哺乳动物中破骨细胞的过度活性相关的疾病中的用途。
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