公开(公告)号：US5744586A

公开(公告)日：1998-04-28

申请号：US668351

申请日：1996-06-26

申请人： John M. Rolf ,  Akimasa Ohmizu ,  Shawn D. Latham ,  Prabir Bhattacharya

发明人： John M. Rolf ,  Akimasa Ohmizu ,  Shawn D. Latham ,  Prabir Bhattacharya

IPC分类号： A61K38/16 ,  A61P43/00 ,  C07K1/18 ,  C07K1/34 ,  C07K14/00 ,  C07K14/79 ,  A61K38/00 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00

CPC分类号： C07K14/79

摘要： Method for obtaining highly purified transferrin from a partially purified plasma fraction containing transferrin in which the starting fraction is concentrated. Its ionic strength is reduced and then transferrin is adsorbed onto a chromatographic column. Following elution, the transferrin can be further processed through to packaging in final containers. The final purified transferrin product is sterile, at least 95% pure and is substantially free of enveloped and non-enveloped viruses.

摘要翻译： 从含有起始级分浓缩的转铁蛋白的部分纯化血浆级分中获得高度纯化的转铁蛋白的方法。 其离子强度降低，然后将转铁蛋白吸附到色谱柱上。 洗脱后，可以将转铁蛋白进一步加工成包装在最终的容器中。 最终纯化的转铁蛋白产物是无菌的，至少95％纯，并且基本上没有包膜和非包膜病毒。

公开(公告)号：USH1960H1

公开(公告)日：2001-06-05

申请号：US08893869

申请日：1997-07-11

申请人： Andrew J. Conrad ,  Charles M. Heldebrant ,  Shawn D. Latham ,  Lorraine B. Peddada

发明人： Andrew J. Conrad ,  Charles M. Heldebrant ,  Shawn D. Latham ,  Lorraine B. Peddada

IPC分类号： G01N3500

摘要： An automated system and process is provided for pooling samples from a multiplicity of blood or plasma donations for subsequent testing to uniquely identify any such blood or plasma donations which may be infected with a particular virus. The system includes an autosampler needle which is directly inserted into a blood or plasma sample aliquot container in order to withdraw an aliquot portion of the contents for forming a sample pool with aliquot portions of other blood or plasma samples. The autosampler comprises a tubular piercing member having a hollow interior bore and a tubular shroud surrounding the piercing member.