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    Surface plasmon resonance sensor with high sensitivity
    3.
    发明申请
    Surface plasmon resonance sensor with high sensitivity 审中-公开
    表面等离子体共振传感器具有高灵敏度

    公开(公告)号：US20060197952A1

    公开(公告)日：2006-09-07

    申请号：US10660833

    申请日：2003-09-12

    Applicant: Shean-Jen Chen ,  Chun-Yu Lin ,  Fan-Ching Chien ,  K.T. Huang ,  W.P. Hu ,  Wen-Yih Chen ,  Kuan-Ching Lee ,  Wen-Hsien Li

    Inventor： Shean-Jen Chen ,  Chun-Yu Lin ,  Fan-Ching Chien ,  K.T. Huang ,  W.P. Hu ,  Wen-Yih Chen ,  Kuan-Ching Lee ,  Wen-Hsien Li

    IPC: G01N21/55

    CPC classification number: G01N21/658 ,  G01N21/554

    Abstract: A high-sensitivity SPR (surface plasmon resonance) sensor includes at least a prism having a first surface on which a metallic layer and a metallic nanoparticle layer are sequentially formed. A light source projects an incident light into the prism through a second surface of the prism. The light is reflected by the metallic layer and the metallic nanoparticle layer and leaves the prism through a third surface of the prism. A light detector detects the reflected light. The SPR sensor has an extensive detection range as compared with the conventional ones and is applicable in the detection of gas, chemical substance, and biomolecule. Moreover, the SPR sensor is advantageous in arranging fabrication process consistently, controlling film thickness, improving product quality, and decreasing fabrication cost.

    Abstract translation: 高灵敏度SPR（表面等离子体共振）传感器至少包括具有顺序地形成有金属层和金属纳米粒子层的第一表面的棱镜。 光源通过棱镜的第二表面将入射光投影到棱镜中。 光被金属层和金属纳米颗粒层反射，并通过棱镜的第三表面离开棱镜。 光检测器检测反射光。 SPR传感器与传统传感器相比具有广泛的检测范围，适用于气体，化学物质和生物分子的检测。 此外，SPR传感器有利于一致地布置制造工艺，控制膜厚度，提高产品质量和降低制造成本。

    Surface plasmon resonance microscope using common-path phase-shift interferometry
    4.
    发明授权
    Surface plasmon resonance microscope using common-path phase-shift interferometry 有权
    表面等离子体共振显微镜使用共轨相移干涉测量

    公开(公告)号：US07339681B2

    公开(公告)日：2008-03-04

    申请号：US11288274

    申请日：2005-11-29

    Applicant: Yuan Deng Su ,  Shean Jen Chen

    Inventor： Yuan Deng Su ,  Shean Jen Chen

    IPC: G01B11/02

    CPC classification number: G01N21/553 ,  B82Y20/00 ,  G01N21/21 ,  G01N21/45 ,  G02B5/008 ,  G02B21/00

    Abstract: The present invention integrates the surface plasmon resonance and common-path phase-shift interferometry techniques to develop a microscope for measuring the two-dimensional spatial phase variation caused by biomolecular interactions on a sensing chip without the need for additional labeling. The common-path phase-shift interferometry technique has the advantage of long-term stability, even when subjected to external disturbances. Hence, the developed microscope meets the requirements of the real-time kinetic studies involved in biomolecular interaction analysis. The surface plasmon resonance microscope of the present invention using common-path phase-shift interferometry demonstrates a detection limit of 2×10−7 refractive index change, a long-term phase stability of 2.5×10−4π rms over four hours, and a spatial phase resolution of 10−3 π with a lateral resolution of 100 μm.

    Abstract translation: 本发明集成了表面等离子体共振和共轨相移干涉测量技术，以开发用于测量由感测芯片上的生物分子相互作用引起的二维空间相位变化的显微镜，而不需要额外的标记。 共轨相移干涉测量技术具有长期稳定的优点，即使在受到外部干扰的情况下也是如此。 因此，研制的显微镜符合生物分子相互作用分析涉及的实时动力学研究的要求。 使用共路相位干涉测量法的本发明的表面等离子体共振显微镜显示了2×10 -7折射率变化的检测极限，2.5×10 -4的长期相位稳定性 4小时以上，并且横向分辨率为100um的空间相位分辨率为10 -3像素。

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